Phyllodes Tumor of the Breast: Role of CD10 in Predicting Metastasis

Abstract

The expression of CD10 can be used to predict the occurrence of distant metastasis in phyllodes tumors of the breast.

Distant metastases in phyllodes tumours of the breast: an overview

“…Al-Masri and colleagues [40] studied the expression of CD10 in 43 cases of PTs and found that positive CD10 expression was significantly associated with the development of distant metastasis (p < 0.05). Ren et al [14] also noted in their study that positive expression of Axl (p = 0.006) and ST6GalNA-cII (p = 0.015) correlated significantly with distant metastasis in PT.…”

Management of Malignant Phyllodes Tumours of the Breast

“…However, details of stromal overgrowth and atypia are not always included in the histology report. More recent studies have implicated aberrant expression of markers such as CD10, Axl, st6galnacii and epidermal growth factor receptor (EGFR) in malignant progression and the development of distant metastases [27][28][29]. Further studies will be needed to validate these findings, and the main difficulty in obtaining more conclusive results lie in the rarity of malignant phyllodes tumours.…”

Phyllodes Tumor Presenting with a Rare Widespread Abdominal Metastases: A Case Report and Review of the Literature

“…However the expression of certain biological markers could help to determine the pattern of tumor activities and to distinguish the different variants. Consequently, immunohistochemistry for mitotic figures, Desmin and Vimentin determine malignancy while cluster of differentiation 10 (CD10) could predict metastasis [7,8,13]. Tumor genomic studies have shown chromosomal mutation, substitutions and deletions in the cell biology of the malignant variants [2,7].…”