Phyllodes Tumor in a Lactating Breast

Murthy, Sudha; Raju, Kalyani; Nair, Haripreetha

doi:10.4137/cpath.s38476

Cited by 9 publications

(17 citation statements)

References 18 publications

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“…Previous review articles on this subject consisted of 7 patients (one bilateral: 8 tumors), 10 9 patients (one bilateral: 10 tumors), 29 and 14 patients (one bilateral: 16 tumors). 35 The mean age of patients in this study was 31 years (21-43 years), younger than the average of 40-45 years for usual PT 50 ; this difference is ordinary because gestational tumors are studied. The youngest patient was 21 and the oldest 43 years old.…”

Section: Discussionmentioning

confidence: 71%

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review

et al. 2020

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Background: Phyllodes tumor (PT) is a rare tumor of the breast, which may occur during pregnancy or lactation. Several studies have reviewed and discussed PT occurring in pregnancy, gathering up to 14 patients. We performed a thorough systematic review of the literature in an attempt to find all reported cases, and identify their common characteristics. Methods: We searched Google scholar, PubMed, Ovid Medline, Scopus and ClinicalTrials.gov with several relevant combinations of keywords, looking for texts or abstracts without any date or language limitations, but using only English keywords. The existing literature only consisted of case reports and series; therefore any paper including one or several cases of PT presenting during pregnancy or breastfeeding was recognized as eligible. Articles with vague description of the tumor which made the diagnosis uncertain, and those lacking data about the tumor and management data were excluded. We contacted authors for more details in cases with incomplete information. Results: After excluding those with very deficient data, we included 37 studies, counting 43 cases. The mean age of the patients was 31 years (21-43 years). Some features were different from usual PT: bilaterality (16.2%), large size (14.2 ± 8.6 cm), rapid enlargement (79.5%), and rate of malignancy (60.5%). Conclusion: Our findings show high rates of bilaterality, large size, rapid growth, and malignant pathology in the reported gestational PTs.

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Section: Discussionmentioning

confidence: 71%

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review

et al. 2020

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“…Murthy et al [15] reported a 25-year-old lactating mother presenting with a lump in the left breast that gross photograph of her specimen demonstrating a grayishwhite well-circumscribed mass with solid and cystic areas. Microscopic findings include fibroepithelial proliferation in a classic leaf-like pattern.…”

Section: Discussionmentioning

confidence: 99%

Low Grade Malignant (Borderline) Phyllodes Tumor of the Breast: Case Report and Review of Literature

Ramezani¹,

Sadeghi²

2017

JCRT

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Phyllodes tumor (PT) of the breast is a rare disease usually presents as a large lump. The aim of this study was to report low grade malignant (borderline) PT of the breast in Kermanshah, Iran. A 55-year-old lady was admitted to the surgery ward with left breast mass since 2-3 months ago. In past medical history, the patient had left breast surgery due to fibrocystic change seven years ago. Grossly her specimen consisted in a piece of gray soft tissue measuring 10*8*4.5 cm with lobulated appearance and small cystic areas. In permanent diagnosis, the pathologist reported low-grade malignant (borderline) PT. Microscopically the tumor was composed of benign glandular elements and hypercellular spindle-shaped stroma. Mitotic index was 3/10 high power field (HPF). The border was well-circumscribed with satellite lesion. In conclusion, the diagnosis of borderline phyllodes tumor cannot be made only on age, the size of tumor, imaging or clinical features. Microscopic evaluation with evaluation of stromal cellularity, atypia, mitotic counts and border of the tumor is necessary for definite diagnosis and categorizing of this tumor.

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“…Fibroadenoma (FA) of the breast is a heterogeneous group of bidirectionally-differentiated tumors with proliferation of both epithelial and stromal components in young women, which belongs to fibroepithelial tumors together with PT. It has been reported in the literature that there are similar gene mutations in PT and FA [ 5 ], so some scholars believe that FA can be converted into PT. However, FA does not actually contain real tumor cells as PT does; therefore, they are two diseases of different types.…”

Section: Introductionmentioning

confidence: 99%

miR-140-3p is a potential differential biomarker in benign phyllodes tumors and fibroadenoma of the breast

Liu

Bai

et al. 2022

BMC Women's Health

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Background Benign phyllodes tumor (BPT) and fibroadenoma (FA) have some difficulties in differential diagnosis. BPT is often misdiagnosed as FA during the first operation and is not diagnosed until postoperative recurrence and reoperation. The intent of this research was to find and validate microRNAs (miRNAs) with significant differential expression between BPT and FA as novel potential differential biomarkers. Methods Tissue specimens from three BPT patients and three FA patients were selected to detect the expression of miRNAs by miRNA-Seq technique. Primary cells were extracted and cultured from fresh BPT and FA tissues by tissue-block culture. The expression of differentially expressed miRNA (DEmiRNA) was further verified by quantitative real-time polymerase chain reaction (qRT-PCR) in twelve BPT and eleven FA patient specimens as well as primary cells. Data with a P value < 0.05 were considered statistically significant. Results The miRNA-Seq results showed totally six DEmiRNA were identified, consisting of two downregulated genes and four upregulated genes in BPT. Further validation by qRT-PCR manifest that miR-140-3p was downregulated by approximately 70% in BPT. Conclusion miR-140-3p could become potential differential biomarker for BPT and FA.

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Phyllodes Tumor in a Lactating Breast

Cited by 9 publications

References 18 publications

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review

Low Grade Malignant (Borderline) Phyllodes Tumor of the Breast: Case Report and Review of Literature

miR-140-3p is a potential differential biomarker in benign phyllodes tumors and fibroadenoma of the breast

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