Phyllodes tumor: Clinicopathologic review of 60 patients and flow cytometric analysis in 30 patients

Keelan, Patrick A.; Wold, Lester E.; Katzmann, Jerry A.; Gibney, Donna J.

doi:10.1016/0046-8177(92)90268-8

Cited by 65 publications

(33 citation statements)

References 17 publications

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“…They are composed of various combinations of proliferating epithelial and stromal elements. 1,4 Phyllodes tumor (PT) is a rare fibroepithelial neoplasm of the breast that account for 0.3% to 1.5% of breast tumors in females and approximately 2.5% of all fibroepithelial breast tumors. 5 Fibroadenoma (FA) is the most common benign tumor that causes breast masses in young women.…”

Section: Introductionmentioning

confidence: 99%

Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: Is it helpful?

Kaya

Pesterelý

Erdoğan

et al. 2001

Pathol. Oncol. Res.

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Section: Introductionmentioning

confidence: 99%

Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: Is it helpful?

Kaya

Pesterelý

Erdoğan

et al. 2001

Pathol. Oncol. Res.

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“…[1][2][3][4][5] Histologic grade, [6][7][8] stromal overgrowth, 9,10 tumor necrosis and heterologous stromal elements, 11 as well as a combination of morphologic parameters, 12 have been traditionally used as predictors of clinical outcome. Nevertheless, specific parameters that can independently define recurrent likelihood are not universally agreed upon.…”

mentioning

confidence: 99%

“…Nevertheless, specific parameters that can independently define recurrent likelihood are not universally agreed upon. 2 A substantial number of reports have concluded that it is the adequacy of surgical margins that is most important, 5,6,[12][13][14] and that histologic features have an inconsistent predictive role.…”

mentioning

confidence: 99%

p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study

et al. 2005

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Breast phyllodes tumors are fibroepithelial neoplasms whose clinical behavior is difficult to predict on histology. There is relatively scant data on the role of biological markers. In this study, we determined if p53 and CD117 (c-kit) protein expression was predictive of behavior in a series of 335 phyllodes tumors diagnosed at the Singapore General Hospital, using immunohistochemistry on tissue microarrays. Representative areas from 250 (75%) benign, 54 (16%) borderline and 31 (9%) malignant phyllodes tumors were selected for construction of tissue microarrays using the 2 mm punch. Immunohistochemistry for p53 and CD117 was carried out using the streptavidin-biotin method. Staining proportion and intensity of both epithelial and stromal elements were analyzed. p53 immunostaining was observed in the epithelium of 28 (10%) of 278 microarrays; myoepithelium of 53 (21%) of 251 microarrays; and stromal cells in 105 (36%) of 289 microarrays. CD117 immunohistochemical reactivity was noted in epithelial and stromal components of 175 (of 267, 66%) and 17 (of 273, 6%) microarrays, respectively. Stromal p53 and CD117 protein expression was associated with tumor grade (Po0.05). Of 43 (13%) women who suffered recurrences during the follow-up period, CD117 stromal staining predicted recurrent disease (Po0.05), but p53 was not correlative. We conclude that tissue microarrays are a convenient method for evaluating immunostaining results of large numbers of phyllodes tumors. Although positive p53 stromal immunohistochemical detection may corroborate histologic malignancy, it is CD117 protein expression in phyllodes tumor stromal cells that may be of potential utility in predicting recurrent disease.

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“…Identification of possible predictive markers of tumor biology that could predict recurrence or metastasis would be useful for the improved treatment of PT. Evidence of an association between markers such as p53 overexpression (5,6) and cell proliferation with histological tumor grade does not add prognostic significance to clinical outcome (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

et al. 2008

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Phyllodes tumor: Clinicopathologic review of 60 patients and flow cytometric analysis in 30 patients

Cited by 65 publications

References 17 publications

Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: Is it helpful?

Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: Is it helpful?

p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study

Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

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