Phyllencit Mixture, a Combination of Medicinal Herbs, as an Antitussive Agent for Acute Cough Treatment: A Pilot Pre-Post Clinical Study

Abstract

Many herbs have shown promising potential in relieving cough and its associated symptoms. 4 PhyllenCit is a herbal anti-cough mixture comprising several beneficial medicinal plants as mentioned in Table 1. A traditional Thai doctor has used it to treat oral diseases, throat irritation, and cough at a Traditional Thai medicine hospital, Prince of Songkla University. The different plants in the mixture include Phyllanthus emblica, 5 Citrus aurantiifolia 6 , Zingiber officinale, 7 and Glycyrrhiza glabra, 8 have been scientifically proved to alleviate cough and other related symptoms. Scientific reports of the anti-cough potency of individual plants in the mixture abound in the literature. However, the combination of these plants as an anti-cough mixture has not been indicated yet. Therefore, the current study has aimed to clinically prove the efficiency and safety of the PhyllenCit mixture in reducing cough and improving quality of life (QOL) in patients with acute cough. Materials and Methods Preparation of PhyllenCit mixtureHerbal components, the common name, the plant part, and the ratio of each plant in the PhyllenCit mixture are shown in Table 1. All the plant materials were bought from a famous Thai herbal shop and identified by our staff botanist. Specimens of these plants with Voucher numbers (PHM001-PHM012) were deposited at the Faculty of Traditional Thai Medicine,

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review

“…The mucolytic activity of shallot extracts by the decrease in the viscosity of the egg albumen was evaluated by Deswati et al It was found that 25% of shallot extracts exerted a mucolytic activity equivalent to 0.2% N-Acetylcysteine ( 114 ). A recent study by Chokpaisarn et al ( 115 ) reported in a pilot pre-post clinical study that PhyllenCit, a herbal anti-cough mixture, containing 3.23% shallot bulbs has a positive effect in suppressing cough and improving the quality of life (QOL) of patients with acute cough. These results confirm the use of shallot in treating cough.…”