Phycomycetous infection (mucormycosis) in cancer patients: A complication of therapy

Hutter, R. V. P.

doi:10.1002/1097-0142(195903/04)12:2<330::aid-cncr2820120217>3.0.co;2-f

Cited by 148 publications

(67 citation statements)

References 34 publications

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“…Many of the original observations were made in patients with solid tumors, leukemias, and lymphomas (64,182,209,297). Researchers linked the acquisition of fungal disease to the onset of neutropenia due to either the progression of the underlying disease or the chemotherapy used in the treatment of the cancerous state (60,166).…”

Section: Risk Factors For Developing Zygomycosismentioning

confidence: 99%

“…Oncomycosis has been seen with infections due to Mucor circinelloides (443), while external otitis has been seen with infections due to Mucor spp. (78,209,355) and Absidia corymbifera (200).…”

Section: General Disease Manifestationsmentioning

confidence: 99%

“…microsporus (233,502) and a handful of cases due to R. microsporus (variety unknown) (261,305) have also been reported. Although Scholer states explicitly in his 1983 chapter that R. stolonifer is not a pathogen (412), there are two reports of disease with this organism (R. nigricans) from the pre-1900 literature summarized in Hutter's review (209). Current literature supports the role of R. stolonifer in stimulating a hypersensitivity pneumonitis (509) but not actual invasive disease.…”

Section: Mucorales Causing Zygomycosis In Humansmentioning

confidence: 99%

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Zygomycetes in Human Disease

Ribes¹,

Vanover-Sams²,

Baker³

2000

Clinical Microbiology Reviews

1,092

1,053

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Section: Risk Factors For Developing Zygomycosismentioning

confidence: 99%

Section: General Disease Manifestationsmentioning

confidence: 99%

Section: Mucorales Causing Zygomycosis In Humansmentioning

confidence: 99%

See 1 more Smart Citation

Zygomycetes in Human Disease

Ribes¹,

Vanover-Sams²,

Baker³

2000

Clinical Microbiology Reviews

1,092

1,053

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“…In immunocompromised patients, risk factors for development of zygomycosis include diabetes mellitus, neutropenia, sustained immunosuppressive therapy, chronic prednisone use, severe malnutrition and primary breakdown in the integrity of the cutaneous barrier such as trauma and surgical wounds. 11,12 Histologically zygomycetes class of fungi exhibit broad, thin-walled, hyaline, often aseptate or pauciseptate hyphae with frequent angioinvasion. The hyphae of the zygomycetes appear thinner-walled compared to other fungal hyphae, which possibly accounts for their weaker staining with Gomori methenamine silver and PAS techniques relative to fungi with thicker cell walls.…”

Section: Discussionmentioning

confidence: 98%

Zygomycotic necrotizing fasciitis in immunocompetent patients: a series of 18 cases

et al. 2006

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Necrotizing fasciitis is most often associated with bacterial infections. Zygomycosis is an uncommon infection causing necrotizing fasciitis. We report 18 such cases of zygomycotic necrotizing fasciitis, of these, 15 were immunocompetent. Of the eight cases cultured, five were positive for Apophysomyces elegans. A retrospective case review conducted at a tertiary referral center, from 1998 to 2004, 18 cases of fungal necrotizing fasciitis were diagnosed based on histomorphology of fungal organisms; and in few of the cases diagnosis was supported by mycologic culture reports. Of the total of 18 cases, culture report was available in eight cases, and out of which five of them grew A. elegans. Fifteen patients were immunocompetent. Clinical presentation, mycologic findings and histopathologic results were evaluated. A review of the literature pertaining to A. elegans infection was also done. Histopathologic examination showed broad, predominantly aseptate and occasional pauciseptate, thin-walled fungal hyphae with occasional angioinvasion. To the best of our knowledge, this is the first largest series of zygomycotic necrotizing fasciitis from India. Herein, we present data on 18 cases of necrotizing fasciitis assosiated with zygomycosis. Most of the cases in our series were immunocompetent. Nonsuppurative necrosis with presence of typical fungal profiles was important histologic feature. Zygomycosis must be considered in the differential diagnosis not only in immunocompromised patients but also in the absence of any underlying disorders.

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“…In a recent comprehensive review of mucormycosis diabetes was known to exist in twenty-two of 114 cases (19 per cent). 2 Of the twenty-two cases of diabetes, the head and neck structures were affected in sixteen (73 per cent), the lung in eight (36 per cent), and the gastrointestinal tract in one (5 per cent).…”

mentioning

confidence: 99%

Diabetes and Mucormycosis

Baker

1960

Diabetes

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Phycomycetous infection (mucormycosis) in cancer patients: A complication of therapy

Cited by 148 publications

References 34 publications

Zygomycetes in Human Disease

Zygomycetes in Human Disease

Zygomycotic necrotizing fasciitis in immunocompetent patients: a series of 18 cases

Diabetes and Mucormycosis

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