Phycocyanin functionalized single-walled carbon nanohorns hybrid for near-infrared light-mediated cancer phototheranostics

Lin, Zhaoxing; Jiang, Bang‐Ping; Liang, Jinzhe; Wen, Changchun; Shen, Xing‐Can

doi:10.1016/j.carbon.2018.12.011

Cited by 35 publications

(15 citation statements)

References 73 publications

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“…Another strategy is the functionalization of nanoparticles with PC in combination with other substances, such as hematoporphyrin monomethyl ether for the noninvasive photodynamic anti-cancer therapy (PDT) [ 94 , 95 ]. In liver and breast cancer mouse model studies, PC-coated nanoparticles were injected in the tumor area and excited by near-infrared (NIR) laser light.…”

Section: Strategies For Potential Phycocyanin-based Anti-cancer Thmentioning

confidence: 99%

Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies

Braune

Krüger‐Genge

Kammerer

et al. 2021

Life

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The application of cytostatic drugs or natural substances to inhibit cancer growth and progression is an important and evolving subject of cancer research. There has been a surge of interest in marine bioresources, particularly algae, as well as cyanobacteria and their bioactive ingredients. Dried biomass products of Arthrospira and Chlorella have been categorized as “generally recognized as safe” (GRAS) by the US Food and Drug Administration (FDA). Of particular importance is an ingredient of Arthrospira: phycocyanin, a blue-red fluorescent, water-soluble and non-toxic biliprotein pigment. It is reported to be the main active ingredient of Arthrospira and was shown to have therapeutic properties, including anti-oxidant, anti-inflammatory, immune-modulatory and anti-cancer activities. In the present review, in vitro and in vivo data on the effects of phycocyanin on various tumor cells and on cells from healthy tissues are summarized. The existing knowledge of underlying molecular mechanisms, and strategies to improve the efficiency of potential phycocyanin-based anti-cancer therapies are discussed.

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Section: Strategies For Potential Phycocyanin-based Anti-cancer Thmentioning

confidence: 99%

Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies

Braune

Krüger‐Genge

Kammerer

et al. 2021

Life

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“…The concept was further confirmed by Landgraf et al 78 , when Au-Fe3O4-SiO2-PEG janus particles were shown to have more PC around them after incubation when compared to Fe3O4-SiO2-PEG NPs. Additionally, several attempts were made for which various functional groups like phycocyanin 79 , methyl phosphonate, PEG 80 etc., are functionalized and adjusted on the NPs with the potential to preform a PC structure through noncovalent interface interactions. This preformed PC improves dispersion in water and inhibits the plasma protein adsorption thereby improving biocompatibility in vivo.…”

Section: Control Of the Surface Chemistry To Tune Pc For In Vivo Applmentioning

confidence: 99%

“…This preformed PC improves dispersion in water and inhibits the plasma protein adsorption thereby improving biocompatibility in vivo. This in turn influences the phototherapeutic efficacy as observed in tumor bearing mice suggesting feasible synergistic photodynamic therapy (PDT)/photothermal therapy (PTT) nanoplatform for the treatment of cancer 79 . Tumor-bearing mice were prepared for the experiment by subcutaneous injection of a suspension of 51064T1 cells.…”

Section: Control Of the Surface Chemistry To Tune Pc For In Vivo Applmentioning

confidence: 99%

In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?

et al. 2021

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“…Interestingly, the greatest decrease in tumor growth was observed when PDT was combined with laser irradiation. This promoted that SWCNH synergistically acted as photothermal agents together with phycocianin [ 107 ]. In conclusion, PDT can be combined with other therapies such as chemotherapy, PTT ( Figure 6 ), or radiotherapy [ 108 ].…”

Section: Swcnh In Cancer Therapymentioning

confidence: 99%

Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer

2020

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Cancer has become one of the most prevalent diseases worldwide, with increasing incidence in recent years. Current pharmacological strategies are not tissue-specific therapies, which hampers their efficacy and results in toxicity in healthy organs. Carbon-based nanomaterials have emerged as promising nanoplatforms for the development of targeted delivery systems to treat diseased cells. Single-walled carbon nanohorns (SWCNH) are graphene-based horn-shaped nanostructure aggregates with a multitude of versatile features to be considered as suitable nanosystems for targeted drug delivery. They can be easily synthetized and functionalized to acquire the desired physicochemical characteristics, and no toxicological effects have been reported in vivo followed by their administration. This review focuses on the use of SWCNH as drug delivery systems for cancer therapy. Their main applications include their capacity to act as anticancer agents, their use as drug delivery systems for chemotherapeutics, photothermal and photodynamic therapy, gene therapy, and immunosensing. The structure, synthesis, and covalent and non-covalent functionalization of these nanoparticles is also discussed. Although SWCNH are in early preclinical research yet, these nanotube-derived nanostructures demonstrate an interesting versatility pointing them out as promising forthcoming drug delivery systems to target and treat cancer cells.

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Phycocyanin functionalized single-walled carbon nanohorns hybrid for near-infrared light-mediated cancer phototheranostics

Cited by 35 publications

References 73 publications

Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies

Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies

In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?

Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer

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