Phthalocyanine functionalized poly(glycidyl methacrylate) nano-assemblies for photodynamic inactivation of bacteria

Abstract

Self-assembled PGED-Pc nanoparticles are able to inactivate bacteria via the generation of reactive oxygen species in aqueous solution, while a facile immobilization strategy sheds light on the engineering of self-sterilizing surfaces to combat bacterial infections.

Turning Photons into Drugs: Phthalocyanine‐Based Photosensitizers as Efficient Photoantimicrobials

“…In another study, Xu and co‐workers synthesized zinc(II)monoamino Pc, which was conjugated to poly(glycidyl methacrylate) via a ring‐opening reaction (Figure 10 c). [81] When dispersed in aqueous solution, self‐assembled nanoparticles (PGED‐Pc NPs) were formed. Photophysical measurements showed that PGED‐Pc NPs generated mainly superoxide/H 2 O 2 instead of the expected 1 O 2 .…”

“…In another study,X ua nd co-workers synthesized zinc(II)monoaminoP c, which was conjugatedt op oly(glycidyl methacrylate) via ar ing-opening reaction (Figure 10 c). [81] When dispersed in aqueous solution,s elf-assembled nanoparticles (PGED-Pc NPs) weref ormed. Photophysicalm easurements showedt hat PGED-Pc NPs generated mainly superoxide/H 2 O 2 insteado ft he expected 1 O 2 .N evertheless,o btained NPsw ere able to inactivateb oth Gram-negative and Gram-positive bacteria in aqueous solutions,w ith am inimum bactericidal con- centrationo f1 28 mgmL À1 for E. coli and 4 mgmL À1 for S. aureus.…”

Synthesis of Polymer Brushes Via SI‐PET‐RAFT for Photodynamic Inactivation of Bacteria

“…Relevant to this work, photodynamic therapy (PDT) is a promising prospect in delivering these desired outcomes. [ 11 ] The in situ generation of reactive oxygen species (ROS), such as cytotoxic singlet oxygen ( 1 O 2 ), is an attractive strategy considering the abundance of environmental oxygen. [ 12 ] In this vein, the incorporation of anthraquinone, [ 13 ] benzophenone, [ 14 ] xanthene, [ 15 ] and porphyrin [ 16 ] photosensitizers into a variety of substrates to convey biocidal activity has been widely explored.…”

Self-decontaminating nanofibrous filters for efficient particulate matter removal and airborne bacteria inactivation

“…This need can be achieved by incorporating antibacterial materials into face mask filters. Conventional strategies of using antibacterial agents such as Ag ions, 29 Cu ions, 30 metal oxides, 31 , and photosentisizers 32 are not very suitable because most of these materials are toxic to humans and environmentally unfriendly.…”