Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

Ekineker, Gülçin; Nguyen, Christophe; Bayır, Sümeyra; Gil, Sofia Dominguez; İşçi, Ümit; Daurat, Morgane; Godefroy, Anastasia; Raehm, Laurence; Charnay, Clarence; Oliviero, E.; Ahsen, Vefa; Gary‐Bobo, Magali; Durand, Jean‐Olivier; Dumoulin, Fabienne

doi:10.1039/c9cc05703j

Cited by 20 publications

(21 citation statements)

References 13 publications

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“…In this study, 50-nm nanoparticles were obtained and amination with APTES was also performed. Here, incubation of the siRNA-containing nanosystems with MCF-7 cells resulted in 64% of luminescence decrease after near-infrared light irradiation, showing the efficiency of photochemical internalization [ 62 ].…”

Section: Silica Nanoparticlesmentioning

confidence: 99%

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

2020

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Advances in gene therapy have been foreshadowing its potential for the treatment of a vast range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and successful outcome are highly dependent on the development of the ideal gene delivery system. On that matter, silica-based vectors have diverted some attention from viral and other types of non-viral vectors due to their increased safety, easily modifiable structure and surface, high stability, and cost-effectiveness. The versatility of silane chemistry and the combination of silica with other materials, such as polymers, lipids, or inorganic particles, has resulted in the development of carriers with great loading capacities, ability to effectively protect and bind genetic material, targeted delivery, and stimuli-responsive release of cargos. Promising results have been obtained both in vitro and in vivo using these nanosystems as multifunctional platforms in different potential therapeutic areas, such as cancer or brain therapies, sometimes combined with imaging functions. Herein, the current advances in silica-based systems designed for gene therapy are reviewed, including their main properties, fabrication methods, surface modifications, and potential therapeutic applications.

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Section: Silica Nanoparticlesmentioning

confidence: 99%

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

2020

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“…The electronic absorption spectra in the UV-Vis region were recorded with a Thermo scientific 2001 UV spectrophotometer using a 1 cm quartz cuvette at room temperature. 1 H NMR spectra were recorded in DMSO-d 6 and CDCl 3 solutions on a Varian 400 MHz spectrometer.…”

Section: Methodsmentioning

confidence: 99%

“…The basis of PDT is photo-chemical reactions induced via excition PS by illumination with appropriate wavelength. Free radicals and singlet oxygen ( 1 O 2 ) are formed by the interaction of this PS with molecular oxygen (O 2 ) [1][2][3]. They interact with many biological molecules (such as fats, proteins and nucleic acids) cause death in cancer cells through apoptosis or necrosis [4].…”

Section: Introductionmentioning

confidence: 99%

Newly Axial Silicon(IV) Phthalocyanine Photosensitizer: Design, Synthesis and Photochemical Properties

Ekineker

Yanık

2020

Celal Bayar Üniversitesi Fen Bilimleri Dergisi

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Phthalocyanines as used a photosensitizer in photodynamic therapy, , phthalocyanines exhibit their long wavelength absorption and the ability to produce high singlet oxygen for tumor destruction with 650 to 900 nm fluorescence. In this study, new axially substituted silicon (IV) phthalocyanine (PS-4) was synthesized to determine photo-chemical properties using 2-methoxyethanol as an axial ligand to increase singlet oxygen quantum yield. Structural characterization of this new axially substituted silicon (IV) phthalocyanine were performed by IR, mass, 1 H NMR and UV-Vis spectroscopic techniques. As axially substituted silicon (IV) phthalocyanine (PS-4) is thought to be a promising PDT agent, photo-chemical properties for cancer treatment with PDT have been investigated.

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“…In the work by Ekiner et al [175] mesoporous organo-silica nanoparticles (PHT-PMO) were prepared based on a silylated Zn-phthalocyanine precursor. PHT-PMO NPs elicited no dark toxicity to MCF7 human breast adenocarcinoma cells but were highly phototoxic atwhen irradiated at 650 (71% death) and 810 nm (63% death) and even more so at 760 nm (80% death).…”

Section: Pci Mediated Oligonucleotide Deliverymentioning

confidence: 99%

Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research

Jerjes¹,

Theodossiou

Hirschberg

et al. 2020

JCM

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Photochemical internalisation (PCI) is a unique intervention which involves the release of endocytosed macromolecules into the cytoplasmic matrix. PCI is based on the use of photosensitizers placed in endocytic vesicles that, following light activation, lead to rupture of the endocytic vesicles and the release of the macromolecules into the cytoplasmic matrix. This technology has been shown to improve the biological activity of a number of macromolecules that do not readily penetrate the plasma membrane, including type I ribosome-inactivating proteins (RIPs), gene-encoding plasmids, adenovirus and oligonucleotides and certain chemotherapeutics, such as bleomycin. This new intervention has also been found appealing for intracellular delivery of drugs incorporated into nanocarriers and for cancer vaccination. PCI is currently being evaluated in clinical trials. Data from the first-in-human phase I clinical trial as well as an update on the development of the PCI technology towards clinical practice is presented here.

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Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

Abstract: Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor and showed powerful NIR photodynamic efficiency and siRNA photochemical internalization.

Cited by 20 publications

References 13 publications

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Newly Axial Silicon(IV) Phthalocyanine Photosensitizer: Design, Synthesis and Photochemical Properties

Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research

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