Phthalates, Pesticides, and Bisphenol-A Exposure and the Development of Nonoccupational Asthma and Allergies: How Valid Are the Links?

Kwak, Ellie; Just, Allan C.; Whyatt, Robin M.; Miller, Rachel L.

doi:10.2174/1874838400902010045

Cited by 37 publications

(28 citation statements)

References 47 publications

(51 reference statements)

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“…One limitation of this sampling approach is the likelihood of selection bias; however, a larger sample size, much like the one employed in our study, may help to reduce selection bias in studies using snowball sampling methodologies [45]. …”

Section: Discussionmentioning

confidence: 99%

Occupational Risks and Pregnancy and Infant Health Outcomes in Florida Farmworkers

Runkle

Flocks

Economos

et al. 2014

IJERPH

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The agricultural industry has some of the highest incidence rates and numbers of occupational injuries and illnesses in the United States. Injuries and illnesses in agriculture result from accidents, falls, excessive heat, repetitive motion and adverse pesticide exposure. Women working in agriculture are exposed to the same hazards and risks as their male counterparts, but can face additional adverse impacts on their reproductive health. Yet, few occupational risk assessment studies have considered the reproductive health of female farmworkers. The objective of this community-based participatory research study was to conduct a retrospective, cross-sectional survey to collect information on workplace conditions and behaviors and maternal, pregnancy and infant health outcomes among a sample of female nursery and fernery farmworkers in Central Florida. Survey results showed that nursery workers were more likely to report health symptoms during their pregnancy than fernery workers. We also observed a self-reported increased risk of respiratory illness in the first year of life for infants whose mothers worked in ferneries. Our findings confirm that agricultural work presents potential reproductive hazards for women of childbearing age.

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Section: Discussionmentioning

confidence: 99%

Occupational Risks and Pregnancy and Infant Health Outcomes in Florida Farmworkers

Runkle

Flocks

Economos

et al. 2014

IJERPH

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“…Our exposure paradigm is a still shorter period, spanning most of a trimester late in gestation; nevertheless, it shows significant effects on the lung. BPA also affects the immune system, leading to speculation that BPA may be involved in the development of asthma and allergy (Kwak et al 2009). BPA has been shown to increase interleukin-4 production in primed CD4 + T cells (helper T cells) and also increases antigen-specific immunoglobulin E in primed mice, potentially enhancing allergic responses (Lee et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…The respiratory health effects of bisphenol A (BPA) have been of recent interest (Kwak et al 2009; Midoro-Horiuti et al 2010; Nakajima et al 2012; Roy et al 2012). BPA is an organic chemical used in the production of polycarbonate plastics and epoxy resins.…”

Section: Introductionmentioning

confidence: 99%

Fetal Exposure of Rhesus Macaques to Bisphenol A Alters Cellular Development of the Conducting Airway by Changing Epithelial Secretory Product Expression

Winkle¹,

Murphy²,

Boetticher³

et al. 2013

Environ Health Perspect

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Background: Bisphenol A (BPA) exposure early in life results in organizational changes in reproductive organs, but the effect of BPA on conducting airway cellular maturation has not been studied. Late gestation is characterized by active differentiation of secretory cells in the lung epithelium.Objective: We evaluated the hypothesis that BPA exposure disrupts epithelial secretory cell development in the fetal conducting airway of the rhesus macaque.Methods: We exposed animals to BPA during either the second (early term) or the third (late term) trimester. There were four treatment groups: a) sham control early term, b) sham control late term, c) BPA early term (BPA-early), and d) BPA late term (BPA-late). Because cellular maturation occurs nonuniformly in the lung, we defined mRNA and protein expression by airway level using microdissection.Results: BPA exposure of the dam during late term significantly accelerated secretory cell maturation in the proximal airways of the fetus; both Clara cell secretory protein (CCSP) and MUC5AC/5B mRNA and protein expression increased.Conclusions: BPA exposure during late gestation accelerates secretory cell maturation in the proximal conducting airways. We identified a critical window of fetal susceptibility for BPA effects on lung epithelial cell maturation in the third trimester. This is of environmental health importance because increases in airway mucins are hallmarks of a number of childhood lung diseases that may be affected by BPA exposure.

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“…Recent reports have stressed the need to understand the potential allergic health effects of phthalates (Dodson et al 2012; Hulin et al 2012; Kwak et al 2009). Although some evidence suggests a role of phthalates in the etiology of allergic sensitization and allergic symptoms, there is a paucity of population-based data, particularly among adults.…”

Section: Introductionmentioning

confidence: 99%

Phthalate Exposure and Allergy in the U.S. Population: Results from NHANES 2005–2006

Hoppin

Jaramillo

London

et al. 2013

Environ Health Perspect

117

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Background: Environmental exposures to phthalates, particularly high-molecular-weight (HMW) phthalates, are suspected to contribute to allergy.Objective: We assessed whether phthalate metabolites are associated with allergic symptoms and sensitization in a large nationally representative sample.Methods: We used data on urinary phthalate metabolites and allergic symptoms (hay fever, rhinitis, allergy, wheeze, asthma) and sensitization from participants ≥ 6 years of age in the National Health and Nutrition Examination Survey (NHANES) 2005–2006. Allergen sensitization was defined as a positive response to at least one of 19 specific IgE antigens (≥ 0.35 kU/L). Odds ratios (ORs) per one log10 unit change in phthalate concentration were estimated using logistic regression adjusting for age, race, body mass index, gender, creatinine, and cotinine. Separate analyses were conducted for children (6–17 years of age) and adults.Results: The HMW phthalate metabolite monobenzyl phthalate (MBzP) was the only metabolite positively associated with current allergic symptoms in adults (wheeze, asthma, hay fever, and rhinitis). Mono-(3-carboxypropyl) phthalate and the sum of diethylhexyl phthalate metabolites (both representing HMW phthalate exposures) were positively associated with allergic sensitization in adults. Conversely, in children, HMW phthalate metabolites were inversely associated with asthma and hay fever. Of the low-molecular-weight phthalate metabolites, monoethyl phthalate was inversely associated with allergic sensitization in adults (OR = 0.79; 95% CI: 0.70, 0.90).Conclusion: In this cross-sectional analysis of a nationally representative sample, HMW phthalate metabolites, particularly MBzP, were positively associated with allergic symptoms and sensitization in adults, but there was no strong evidence for associations between phthalates and allergy in children 6–17 years of age.Citation: Hoppin JA, Jaramillo R, London SJ, Bertelsen RJ, Salo PM, Sandler DP, Zeldin DC. 2013. Phthalate exposure and allergy in the U.S. population: results from NHANES 2005–2006. Environ Health Perspect 121:1129–1134; http://dx.doi.org/10.1289/ehp.1206211 [Online 25 June 2013].

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Phthalates, Pesticides, and Bisphenol-A Exposure and the Development of Nonoccupational Asthma and Allergies: How Valid Are the Links?

Cited by 37 publications

References 47 publications

Occupational Risks and Pregnancy and Infant Health Outcomes in Florida Farmworkers

Occupational Risks and Pregnancy and Infant Health Outcomes in Florida Farmworkers

Fetal Exposure of Rhesus Macaques to Bisphenol A Alters Cellular Development of the Conducting Airway by Changing Epithelial Secretory Product Expression

Phthalate Exposure and Allergy in the U.S. Population: Results from NHANES 2005–2006

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