Phthalates dietary exposure and food sources for Belgian preschool children and adults

Sioen, Isabelle; Fierens, Tine; Holderbeke, Mirja Van; Geerts, Lieve; Bellemans, Mia; Maeyer, Mieke De; Servaes, Kelly; Vanermen, Guido; Boon, Polly; Henauw, Stefaan De

doi:10.1016/j.envint.2012.07.004

Cited by 85 publications

(59 citation statements)

References 24 publications

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“…The non-carcinogenic risk of DEP to male and female were lower than 1 % of those of DEHP. The order of non-carcinogenic risk induced by DEHP, DnBP, and DEP was similar to the results of Sioen et al (Sioen et al 2012) that concerned the PAEs' daily intake through food and reported that PAEs' exposure dosage followed an order of DEHP> DnBP>DEP. Consequently, the great difference in noncarcinogenic risks of PAEs might be explained by the higher concentration in source water and lower RfDs of DEHP and DnBP (see Table S2).…”

Section: Non-carcinogenic Risk Of Paes In Drinking Water Sourcessupporting

confidence: 74%

Health risk assessment of phthalate esters (PAEs) in drinking water sources of China

Wang

et al. 2014

Environ Sci Pollut Res

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Phthalate esters (PAEs) with endocrine disruption effects and carcinogenicity are widely detected in water environment. Occurrences of PAEs in source water and removal efficiencies of PAEs by drinking water treatment plants (DWTPs) in China were surveyed from publications in the last 10 years. Concentration of diethylhexyl phthalate (DEHP) in source water with median value of 1.3 μg/L was higher than that of dimethyl phthalate (DMP), diethyl phthalate (DEP), and di-n-butyl phthalate (DnBP). If the removal efficiencies of DEHP and DnBP reached 60 and 90 %, respectively, the calculated PAE concentration in drinking water can generally meet Standards for Drinking Water Quality in China. The health risks of PAEs, including non-carcinogenic and carcinogenic risks via the "water source-DWTP-oral ingestion/dermal permeation" pathway, were evaluated with Monte Carlo simulation and sensitivity analysis under certain removal efficiencies from 0 to 95 %. The carcinogenic risk of DEHP was lower than the upper acceptable carcinogenic risk level (10(-4)), while the probability of DEHP's carcinogenic risk between lower (10(-6)) and upper (10(-4)) acceptable carcinogenic risk level decreased from about 21.2 to 0.4 % through increasing DEHP removal efficiency from 0 to 95 %. The non-carcinogenic risk of DEHP was higher than that of DEP and DnBP. In all cases, the total non-carcinogenic risk of DEP, DnBP, and DEHP was lower than 1, indicating that there would be unlikely incremental non-carcinogenic risk to humans. Both carcinogenic risk and non-carcinogenic risk of PAEs in drinking water to female were a little higher than those to male.

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Section: Non-carcinogenic Risk Of Paes In Drinking Water Sourcessupporting

confidence: 74%

Health risk assessment of phthalate esters (PAEs) in drinking water sources of China

Wang

et al. 2014

Environ Sci Pollut Res

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“…Since phthalates are not covalent bound in plastic materials, they can be release slowly from products into the surrounding environment and into food items (EPA 2007;Leitz et al 2009;Wittassek et al 2011). As a result, the general population is widely and continuously exposed to phthalates through dietary intake, inhalation, and dermal contact throughout their lifetimes (Heudorf et al 2007;Sioen et al 2012). Suspicions of harmful effects of phthalates on human health have recently been brought to the attention (Singh and Li 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Phthalates (dialkyl or alkyl aryl esters of o-phthalic acid) are a group of organic chemicals that have applications in many industrial and consumer sectors for more than 50 years in our daily lives (EPA 2007;Sioen et al 2012). Among phthalate group of chemicals, the diethyl ester of phthalic acid (DEP), one of the low molecular weight phthalate esters, is the one which has many industrial uses especially as plasticizers (Api 2001).…”

Section: Introductionmentioning

confidence: 99%

A margin of exposure approach to assessment of non-cancerous risk of diethyl phthalate based on human exposure from bottled water consumption

Jeddi

Rastkari

Ahmadkhaniha

et al. 2015

Environ Sci Pollut Res

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Phthalates may be present in food due to their widespread presence as environmental contaminants or due to migration from food contact materials. Exposure to phthalates is considered to be potentially harmful to human health as well. Therefore, determining the main source of exposure is an important issue. So, the purpose of this study was (1) to measure the release of diethyl phthalate (DEP) in bottled water consumed in common storage conditions specially low temperature and freezing conditions; (2) to evaluate the intake of DEP from polyethylene terephthalate (PET) bottled water and health risk assessment; and (3) to assess the contribution of the bottled water to the DEP intake against the tolerable daily intake (TDI) values. DEP migration was investigated in six brands of PET-bottled water under different storage conditions room temperature, refrigerator temperature, freezing conditions (40 °C ,0 °C and -18 °C) and outdoor] at various time intervals by magnetic solid extraction (MSPE) using gas chromatography-mass spectroscopy (GC-MS). Eventually, a health risk assessment was conducted and the margin of exposure (MOE) was calculated. The results indicate that contact time with packaging and storage temperatures caused DEP to be released into water from PET bottles. But, when comprising the DEP concentration with initial level, the results demonstrated that the release of phthalates were not substantial in all storage conditions especially at low temperatures (<25 °C) and freezing conditions. The daily intake of DEP from bottled water was much lower than the reference value. However, the lowest MOE was estimated for high water consumers (preschooler > children > lactating women > teenagers > adults > pregnant women), but in all target groups, the MOE was much higher than 1000, thus, low risk is implied. Consequently, PET-bottled water is not a major source of human exposure to DEP and from this perspective is safe for consumption.

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“…Utóbbi években azonban jelentősen fellendült a módszer alkalmazása a kémiai anyagok étrendi expozíciójának becslésében [Hamey 2000, Pieters et al 2004, Katz és Winter 2009, Ruprich et al 2009, Mojska et al 2010, Fernandes et al 2011, Cano-Sancho et al 2012, Medeiros Vinci et al 2012, Heinemeyer et al 2013, He et al 2013, Yuan et al 2014. Viszonylag nagy publikációs aktivitást mutattak egyes belga [Claeys et al 2008, Claeys et al 2010, Claeys et al 2011, Sioen et al 2012, De Boevre et al 2013, dán [Jensen et al 2008] és brazil [Jardim és Caldas 2012] szerzők is, akik a peszticid maradékok probabilisztikus expozícióbecslése területén tevékenykednek.…”

Section: 4a Probabilisztikus Becslésunclassified

“…egy belga ftalát expozícióbecslésnél a háromnapi fogyasztási adatokat javították a BBN modellel [Sioen et al 2012]. Ehhez a napi expozíciókat logaritmikus transzformációval normál eloszlássá alakították.…”

Section: ])unclassified

Növényvédőszer-maradékok és más szennyezőanyagok élelmiszer-fogyasztásból származó akut expozíciójának probabilisztikus modellezése

Zentai¹

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Phthalates dietary exposure and food sources for Belgian preschool children and adults

Cited by 85 publications

References 24 publications

Health risk assessment of phthalate esters (PAEs) in drinking water sources of China

Health risk assessment of phthalate esters (PAEs) in drinking water sources of China

A margin of exposure approach to assessment of non-cancerous risk of diethyl phthalate based on human exposure from bottled water consumption

Növényvédőszer-maradékok és más szennyezőanyagok élelmiszer-fogyasztásból származó akut expozíciójának probabilisztikus modellezése

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