Phthalates and fetal growth velocity: tracking down the suspected links

Vrachnis, Nikolaos; Loukas, N.H.; Vrachnis, Dionysios; Antonakopoulos, Nikolaos; Christodoulaki, Chrysi; Tsonis, Orestis; Mastorakos, George; Iliodromiti, Zoe

doi:10.1080/14767058.2021.1873943

Cited by 7 publications

(2 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endocrine-disrupting chemicals (EDCs) exist as both natural and man-made compounds that can interfere with metabolism, hormonal homeostasis, and the functioning of the endocrine system either by mimicking or by blocking the biological activity of endogenous hormones. They have been associated with adverse effects in both human and animal studies and are considered to be potentially harmful factors predisposing to abnormal fetal growth, since the majority of them are able to cross the protective placental barrier and enter the fetal circulation, as revealed by the detection of EDCs in fetal biological samples such as amniotic fluid and/or cord blood [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Bisphenol A: Is There an Association between Bisphenol A in Second Trimester Amniotic Fluid and Fetal Growth?

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background and Objectives: Fetal growth abnormalities increase the risk of negative perinatal and long-term outcomes. Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical to which humans may be exposed in a number of ways, such as from the environment, via various consumer products, and through the individual’s diet. Since the compound possesses estrogen-mimicking properties and exerts epigenetic and genotoxic effects, it has been associated with harmful effects impacting the entire spectrum of human life, including, vitally, the intrauterine period. We investigated the role of maternal exposure to BPA in abnormal fetal growth velocity, both impaired and excessive. Materials and Methods: Amniotic fluid samples were collected from 35 women who underwent amniocentesis early in the second trimester due to medical reasons. Pregnancies were followed until delivery, and birth weights were recorded. The amniotic fluid samples were subsequently divided into three groups based on fetal birth weight, as follows: AGA (appropriate for gestational age), SGA (small for gestational age), and LGA (large for gestational age). Amniotic fluid BPA levels were determined by gas chromatography coupled with mass spectrometry. Results: BPA was detected in 80% (28/35) of our amniotic fluid samples. Median concentration was 281.495 pg/mL and ranged from 108.82 pg/mL to 1605.36 pg/mL. No significant association was observed between the study groups regarding BPA concentration. A significant positive correlation between amniotic fluid BPA concentration and birth weight centile (r = 0.351, p-value = 0.039) was identified. BPA levels were also inversely associated with gestational age in pregnancies at term (between 37 and 41 weeks) (r = −0.365, p-value = 0.031). Conclusions: Our findings suggest that maternal exposure to BPA during the early second trimester of pregnancy can potentially contribute to increased birthweight percentiles and to decreased gestational age in pregnancies at term.

show abstract

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Bisphenol A: Is There an Association between Bisphenol A in Second Trimester Amniotic Fluid and Fetal Growth?

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…The ubiquitous exposure of humans to endocrine disruptors (EDs) has been associated with disruption of reproductive health and fertility problems, while prenatal exposure has been linked to, among others, fetal neurodevelopmental health and growth restriction [ 16 , 17 ]. These effects have raised concerns over the past few decades regarding the ability of this substance to nullify the beneficial role of nutrients in foods such as vegetables and milk and to impede the nutrient absorption of vegetables cultivated in soil contaminated with BPA.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Bisphenol A from Dietary and Non-Dietary Sources during Pregnancy and Its Possible Connection with Fetal Growth Restriction: Investigating Its Potential Effects and the Window of Fetal Vulnerability

et al. 2021

Self Cite

View full text Add to dashboard Cite

Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical (EDC), is increasingly hypothesized to be a factor contributing to changes in fetal growth velocity. BPA exposure may be environmental, occupational, and/or dietary, with canned foods and plastic bottles contributing significantly. Our systematic review aims to evaluate the current literature and to investigate the role of BPA in abnormal fetal growth patterns. A search was conducted in the PubMed and Cochrane databases. A total of 25 articles met the eligibility criteria and were included in this systematic review. Eleven of them failed to show a clear relationship between BPA and abnormal fetal growth. The majority of the remaining studies (9/14) found an inverse association of BPA with indicators of fetal growth, whereas three studies suggested increased fetal growth, and two studies produced contradictory findings. Of note, both of the studies that collected a sample (amniotic fluid) directly reflecting BPA concentration in the fetus during the first half of pregnancy revealed an inverse association with birth weight. In conclusion, there is mounting evidence that combined exposure to BPA from dietary and non-dietary sources during pregnancy may contribute to abnormal fetal growth; a tendency towards fetal growth restriction was shown, especially when exposure occurs during the first half.

show abstract

Maslinic acid supplementation prevents di(2-ethylhexyl) phthalate-induced apoptosis via PRDX6 in peritubular myoid cells of Chinese forest musk deer

Cao

Jin

et al. 2024

Journal of Environmental Sciences

View full text Add to dashboard Cite

Phthalates and fetal growth velocity: tracking down the suspected links

Cited by 7 publications

References 62 publications

Prenatal Exposure to Bisphenol A: Is There an Association between Bisphenol A in Second Trimester Amniotic Fluid and Fetal Growth?

Prenatal Exposure to Bisphenol A: Is There an Association between Bisphenol A in Second Trimester Amniotic Fluid and Fetal Growth?

A Systematic Review of Bisphenol A from Dietary and Non-Dietary Sources during Pregnancy and Its Possible Connection with Fetal Growth Restriction: Investigating Its Potential Effects and the Window of Fetal Vulnerability

Maslinic acid supplementation prevents di(2-ethylhexyl) phthalate-induced apoptosis via PRDX6 in peritubular myoid cells of Chinese forest musk deer

Contact Info

Product

Resources

About