Phthalate metabolites in urine of Chinese young adults: Concentration, profile, exposure and cumulative risk assessment

Gao, Chong-Jing; Liu, Liyan; Ma, Wan–Li; Ren, Nanqi; Guo, Ying; Zhu, Ning-Zheng; Jiang, Ling; Li, Yifan; Kannan, Kurunthachalam

doi:10.1016/j.scitotenv.2015.11.005

Cited by 97 publications

(32 citation statements)

References 69 publications

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“…However, we also found positive relationships between urinary MEP and free T4 levels, which were inconsistent with previous studies (Brown et al, 1978;Pereira et al, 2007). Although personal care products and cosmetics are potential sources of DEP exposure in Chinese adults (Gao et al, 2016), little information is available on whether frequent DEP exposure alters thyroid hormones. Mechanistic studies are necessary to elucidate our findings.…”

Section: Discussioncontrasting

confidence: 99%

Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Survey for Toxicants (TEST) 2013

Huang

Pan

Chang

et al. 2017

Environmental Research

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Section: Discussioncontrasting

confidence: 99%

Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Survey for Toxicants (TEST) 2013

Huang

Pan

Chang

et al. 2017

Environmental Research

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“…These concentrations were similar to the previous reports in general populations from China and USA [36,37], but lower than that in Mexico [38]. The concentrations of M i BP (8.42) and M n BP (12.92) in this study was lower than the reported values in previous studies from China [36,39]. …”

Section: Resultssupporting

confidence: 87%

“…First, DEHP oxidative metabolites are of higher stability and sensitivity in determination, whereas MEHP has a shorter serum half-life than the other metabolites [40]. The detection rates of four DEHP oxidative metabolites (MEOHP, MECPP, MEHHP, MCMHP) in our samples were similar to the relevant studies published from 2007 to 2016, which were all above 90% [39,41,42,43,44,45]. Second, it has been reported that MEHHP and MEOHP was more active in animals than MEHP [46].…”

Section: Discussionsupporting

confidence: 74%

Sex Differences in the Association of Urinary Concentrations of Phthalates Metabolites with Self-Reported Diabetes and Cardiovascular Diseases in Shanghai Adults

Dong

Zhao

Zhang

et al. 2017

IJERPH

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Phthalate exposure was reported to be associated with diabetes mellitus (DM) and cardiovascular disease (CVD). Yet, reported associations and the potential sex differences are inconsistent. We conducted a cross-sectional study involving 2330 participants in the Fall of 2012. Urinary metabolites of 10 phthalates were measured. The status of having DM and CVD-related outcomes were self-reported. In the overall study population, the logistic regression analyses showed that the urinary levels of mono-2-ethyl-5-oxohexyphthalate (MEOHP), mono-2-ethyl-5-hydroxyhexylphthalate(MEHHP) and mono-2-ethyl-5-carboxypentylphthalate (MECPP) were positively associated with DM. Higher urinary levels of monomethyl phthalate (MMP) and mono-2-carboxymethyl-hexyl phthalate (MCMHP) were associated with increased odds of hyperlipidemia, while mono-2-ethylhexylphthalate (MEHP) was significantly inverse-associated with hyperlipidemia. We did not observe significant associations for other CVD-related outcomes with phthalate metabolites. When stratifying by sex, MEHHP, MEOHP, MECPP, MCMHP and the micromolar sums of the oxidative metabolites of DEHP (ΣDEHPox) were all significantly related to DM in males, but not in females. No significant sex differences were found in CVD-related outcomes, except the sporadic associations between phthalates and hyperlipidemia. These findings highlight the importance of investigating the sex-specific relationship between phthalates exposure and DM.

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“…Hays and colleagues developed the biomonitoring equivalents to evaluate the risk from urine data for DiNP33. Several studies have reconstructed daily does from phthalate or its metabolites in urine for comparison to the existing RfD3435. These studies show that exposure reconstruction from phthalate and its metabolites in urine are regarded as the most reliable method to quantify overall exposure to phthalates because phthalate metabolites in urine are not likely to have bias by external contamination.…”

Section: Discussionmentioning

confidence: 99%

Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal

Chang

Lee

Pan

et al. 2017

Sci Rep

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A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan’s general population after the scandal. The DIs of 6 phthalates, including di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), and DEHP, were evaluated using urinary phthalate metabolites. Hazard quotients of phthalates classified as affecting the reproductive (HQrep) and hepatic (HQhep) systems were assessed using cumulative approach. The creatinine-based model showed that the highest DI values in children 7-to 12- years-old were for DEHP (males: median: 4.79 μg/kg bw/d; females: median: 2.62 μg/kg bw/d). The 95th percentile (P95) of HQrep values were all >1 in the 7- to 12-year-old and 18- to 40-year-old male groups. The P95 of HQhep values were all >1 in the 7- to 18- year-old male groups. Most of the HQrep was attributable to the HQs of DnBP and DiBP (53.9–84.7%), and DEHP contributed most to HQhep (83.1–98.6%), which reveals that DnBP, DiBP and DEHP were the main risk of phthalate exposure for Taiwanese. Taiwan’s general population is widely exposed to DnBP, DiBP and DEHP, especially for young children.

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Phthalate metabolites in urine of Chinese young adults: Concentration, profile, exposure and cumulative risk assessment

Cited by 97 publications

References 69 publications

Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Survey for Toxicants (TEST) 2013

Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Survey for Toxicants (TEST) 2013

Sex Differences in the Association of Urinary Concentrations of Phthalates Metabolites with Self-Reported Diabetes and Cardiovascular Diseases in Shanghai Adults

Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal

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