Phthalate exposure with sperm quality among healthy Chinese male adults: The role of sperm cellular function

Pan, Yang; Xie, Jin-Ying; Li, Xiaojie; Wang, Xiaona; Sun, Bin; Meng, Tian-Qing; Xiong, Chengliang; Huang, Yichao; Wang, Yixin; Pan, An; Chen, Da; Yang, Yan

doi:10.1016/j.envpol.2023.121755

Cited by 5 publications

(2 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous epidemiological studies have consistently reported associations between exposure to phthalates and their alternatives, and a range of adverse health outcomes. These include poor neurodevelopment, asthma, and reproductive health issues (Zhu et al, 2022;Arrigo et al, 2023;Chen et al, 2023a;Yang et al, 2023). The underlying mechanisms of how phthalate exposure impacts health effects remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Jin,

Cui,

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Phthalates and their alternatives are considered signi cant environmental risk factors that potentially in uence in ammation and oxidative stress. However, their impact on biomarkers of in ammation and oxidative stress was inconsistent. This study aimed to explore the associations between phthalates and high-sensitivity C-reactive protein (hsCRP), gamma-glutamyl transferase (GGT), and white blood cell (WBC) counts, employing both univariate exposure and multivariate co-exposure models. For this analysis, a total of 1619 individuals aged 18 years and above, sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 2017 and 2018, were selected as subjects. We explored the associations between hsCRP, GGT, and WBC counts and eighteen different phthalate metabolites. Multiple linear regression analysis revealed signi cant associations between hsCRP and two speci c metabolites: MCNP (β = 0.060, P = 0.034) and MEHP (β = -0.054, P = 0.049). We observed negative correlations of MCOP, MCPP, MHBP, and MONP with GGT (β = -0.036, P = 0.027; β = -0.045, P = 0.019; β = -0.046, P = 0.023; β = -0.053, P = 0.001, respectively). Conversely, MEHHP and MEHTP exhibited positive correlations with GGT (β = 0.048, P = 0.011; β = 0.029, P = 0.009). Furthermore, MECPTP and MEHTP showed positive correlations with WBC (β = 0.011, P = 0.026; β = 0.017, P = 0.001). Notably, we identi ed a non-linear relationship between phthalates and in ammation and oxidative stress markers.The Bayesian kernel machine regression (BKMR) analysis demonstrated a negative joint effect of the phthalates mixture on GGT, particularly at lower concentrations. The BKMR model also found that MEOHP and MHiBP were negatively associated with GGT. In contrast, MEHHP showed a signi cant positive association with GGT. Moderating effect analysis suggested that increased dietary in ammatory index (DII), income-to-poverty ratio (PIR), age, BMI, and less physical activity strengthened the association between phthalates and in ammation and oxidative stress. These ndings contribute to a deeper understanding of the relationships between phthalates and in ammation and oxidative stress.

show abstract

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Jin,

Cui,

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: Evidence from NHANES 2017-2018

Jin,

Cui,

et al. 2023

Preprint

View full text Add to dashboard Cite

Phthalates and their alternatives are considered significant environmental risk factors that potentially influence inflammation and oxidative stress. However, their impact on biomarkers of inflammation and oxidative stress was inconsistent. This study aimed to explore the associations between phthalates and high-sensitivity C-reactive protein (hsCRP), gamma-glutamyl transferase (GGT), and white blood cell (WBC) counts, employing both univariate exposure and multivariate co-exposure models. For this analysis, a total of 1619 individuals aged 18 years and above, sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 2017 and 2018, were selected as subjects. We explored the associations between hsCRP, GGT, and WBC counts and eighteen different phthalate metabolites. Multiple linear regression analysis revealed significant associations between hsCRP and two specific metabolites: MCNP (β = 0.060, P = 0.034) and MEHP (β = -0.054, P = 0.049). We observed negative correlations of MCOP, MCPP, MHBP, and MONP with GGT (β = -0.036, P = 0.027; β = -0.045, P = 0.019; β = -0.046, P = 0.023; β = -0.053, P = 0.001, respectively). Conversely, MEHHP and MEHTP exhibited positive correlations with GGT (β = 0.048, P = 0.011; β = 0.029, P = 0.009). Furthermore, MECPTP and MEHTP showed positive correlations with WBC (β = 0.011, P = 0.026; β = 0.017, P = 0.001). Notably, we identified a non-linear relationship between phthalates and inflammation and oxidative stress markers. The Bayesian kernel machine regression (BKMR) analysis demonstrated a negative joint effect of the phthalates mixture on GGT, particularly at lower concentrations. The BKMR model also found that MEOHP and MHiBP were negatively associated with GGT. In contrast, MEHHP showed a significant positive association with GGT. Moderating effect analysis suggested that increased dietary inflammatory index (DII), income-to-poverty ratio (PIR), age, BMI, and less physical activity strengthened the association between phthalates and inflammation and oxidative stress. These findings contribute to a deeper understanding of the relationships between phthalates and inflammation and oxidative stress.

show abstract

Alleviative effect of quercetin against reproductive toxicity induced by chronic exposure to the mixture of phthalates in male rats

Xia,

Liu,

Yue

et al. 2024

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

Phthalate exposure with sperm quality among healthy Chinese male adults: The role of sperm cellular function

Cited by 5 publications

References 77 publications

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: Evidence from NHANES 2017-2018

Alleviative effect of quercetin against reproductive toxicity induced by chronic exposure to the mixture of phthalates in male rats

Contact Info

Product

Resources

About