Phthalate exposure through different pathways and allergic sensitization in preschool children with asthma, allergic rhinoconjunctivitis and atopic dermatitis

Bekö, Gabriel; Callesen, Michael; Weschler, Charles J.; Toftum, Jørn; Langer, Sarka; Sigsgaard, Torben; Høst, Arne; Jensen, Tina Kold; Clausen, Geo

doi:10.1016/j.envres.2015.01.012

Cited by 93 publications

(35 citation statements)

References 42 publications

(65 reference statements)

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“…In addition, effects of early life phthalate exposure on immunoglobulin E (IgE) levels can potentially cause atopic dermatitis (AD) in children in a 10-year cohort [32, 37]. Indoor dust that includes di-2-ethylhexyl phthalate (DEHP) is associated with wheezing in preschool-aged children [6, 23]. Moreover, another study has reported that higher levels of BBzP and DiBP in house dust increase OR of atopic dermatitis among children [2].…”

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis

et al. 2017

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BackgroundDespite increasing evidence on the relationship between exposure to phthalates and bisphenol A with allergies and asthma, reports on atopic dermatitis (AD) with these chemicals are few. We assessed the association between AD symptoms and the exposure to phthalates and bisphenol A and in children. MethodsWe surveyed 18 boys with AD (age 3–7 years) in a day care center in Seoul between May 2009 and April 2010. AD symptoms were recorded by using a daily symptom diary. We collected 460 series of pooled urine twice a day, in the morning and afternoon, over 230 working days and measured the concentrations of mono–2–ethyl-5-oxohexyl phthalate (5-oxo-MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (5-OH-MEHP), mono-isobutyl phthalate (MnBP) and bisphenol A glucuronide (BPAG) in the pooled urine. Logistic regression was used for statistical analysis.ResultsMost phthalate metabolite levels were higher in the morning than in the afternoon (p < 0.0001). There was seasonal variation in the levels of phthalates and bisphenol A metabolites. Levels of 5-OH-MEHP, MnBP, and BPAG were highest in summer (p < 0.0001). Manifestation of AD symptoms was associated with an increase in urinary levels of MnBP (adjusted odds ratio, aOR = 2.85, 95% CI: 1.12-7.26 per 1 μg/L of MnBP) and BPAG (aOR = 1.79, 95% CI: 0.91-3.52 per 1 μg/L BPAG) on the same day. The levels of MnBP and BPAG in the previous day increased AD symptoms (aOR = 2.74, 95% CI: 1.21-6.20, for 1 μg/L of MnBP and aOR = 2.01, 95% CI: 1.08-3.74 for 1 μg/L BPAG).ConclusionOur results suggest that exposure to phthalates and bisphenol A is associated with aggravation of AD symptoms in children.

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Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis

et al. 2017

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“…ICD can be induced by DDT, PCBs, and phthalates in the insect repellants, solvents, detergents, and cosmetics [11]. ACD due to contact with parabenes and phthalates has been reported [24,51,52]. Systemic or topical PAHs contact through cigarette smoking or occupational exposure was found to be related to allergic rhinitis, asthma, ICD, or ACD [50,53].…”

Section: Inflammatory and Allergic Skin Diseasesmentioning

confidence: 97%

“…Phthalates are also employed in skin care products or other products as stabilizers, binders, emulsifiers, and lubricants, including skin moisturizers, mosquito repellents, perfumes, deodorants, shampoos, and nail polishers [23]. There are many reports of allergic contact dermatitis (ACD) [24,25], and phthalates were even responsible for recent increase prevalence of irritant contact dermatitis (ICD) [26]. Prenatal exposure to BBzP, as measured by levels of MBzP in spot urine samples during the third trimester of pregnancy, has been associated with a risk of developing eczema in early childhood [27].…”

Section: The Toxic Effects Of Edcs On the Skinmentioning

confidence: 99%

Endocrine-disrupting chemicals and skin manifestations

Qiang

Zouboulis

2016

Rev Endocr Metab Disord

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Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Human health is affected after either individual occupation or dietary and environmental exposure to EDCs. On the other hand, skin is one of the largest organs of the body and its main function is protection from noxious substances. EDCs perturb the endocrine system, and they are also carcinogenic, immunotoxic, and hepatotoxic to human skin. In addition, their effects on keratinocytes, melanocytes, sebocytes, inflammatory and immunological cells, and skin stem cells produce inflammatory and allergic skin diseases, chloracne, disorders of skin pigmentation, skin cancer, and skin aging. Mechanisms, which EDCs use to induce these skin disorders are complicated, and involve the interference of endogenous hormones and most importantly the activation of the aryl hydrocarbon receptor signal pathway. Further studies on EDCs and skin diseases are necessary to elucidate these mechanisms.

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“…Patients with AD often develop asthma and allergic rhinitis, a progression referred to as the "atopic march" (Huang et al, 2003;Bieber, 2008). Epidemiological studies have shown that there is a possible relationship between phthalate exposure and the risk of allergy in workers in the plastics industry as well as in children (Bornehag and Nanberg, 2010;Bekö et al, 2015). Since AD can have a dramatically bad impact on human health, it is pressing and important to study its pathogenesis.…”

Section: Introductionmentioning

confidence: 98%

Long-term dermal exposure to diisononyl phthalate exacerbates atopic dermatitis through oxidative stress in an FITC-induced mouse model

et al. 2015

Front. Biol.

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Diisononyl phthalate (DINP), considered to be an environmentally friendly plasticizer, is now widely used. However, the toxic effects of DINP need to be examined, particularly the effects of long-term dermal DINP exposure. Research into the mechanisms underlying these effects is urgently needed. In this study we examined the exacerbation effect of long-term dermal exposure to DINP in fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) in mice, and sought the potential molecular mechanisms. Forty-nine male Balb/c mice were subjected to a 40-day dermal exposure to saline or one of three concentrations of DINP and then three rounds of sensitization with vehicle or 0.5% FITC. The results of a histopathological examination and measurement of ear swelling as well as immunological and inflammatory biomarkers (total-immunoglobulin (Ig)E and Th cytokines) supported the notion that high doses of DINP may aggravate atopic dermatitis. We also showed that melatonin, an antioxidant, could decrease the levels of oxidative stress and alleviate FITC-induced CHS suggesting that oxidative stress may be one of the molecular mechanisms to explain the exacerbation effect induced by DINP.

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Phthalate exposure through different pathways and allergic sensitization in preschool children with asthma, allergic rhinoconjunctivitis and atopic dermatitis

Cited by 93 publications

References 42 publications

Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis

Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis

Endocrine-disrupting chemicals and skin manifestations

Long-term dermal exposure to diisononyl phthalate exacerbates atopic dermatitis through oxidative stress in an FITC-induced mouse model

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