Phthalate exposure and neurodevelopmental outcomes in early school age children from Poland

Jankowska, Agnieszka; Polańska, Kinga; Koch, Holger M.; Pälmke, Claudia; Waszkowska, Małgorzata; Stańczak, Aleksander; Wesołowska, Ewelina; Hanke, Wojciech; Blüml, Stephan; Calamandrei, Gemma; Garí, Mercè

doi:10.1016/j.envres.2019.108829

Cited by 27 publications

(17 citation statements)

References 46 publications

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“…Similarly, prenatal exposure to DBP and BBzP was significantly associated with language delay in children in the US and Sweden [53]. The adverse mental and psychomotor development of children in association with maternal exposure to DEHP was reported in a Korean study [52]. A study using different test batteries also found that the verbal comprehension index of children was negatively associated with urinary MEOHP and the sum of DBP metabolites [49].…”

Section: Phthalates and Neurodevelopmentmentioning

confidence: 80%

“…A fair number of longitudinal studies were found, and a wide variety of neurobehavioral outcomes were assessed at various age ranges. The Bayley Scales of Infant Development (BSID) is widely used in longitudinal studies to assess cognitive and psychomotor development in young children [46,47,50,52,56]. Among the 6 studies that used BSID, 2 studies did not find any significant adverse effects of prenatal exposure to phthalates and cognitive, mental, and psychomotor development of children [46,47].…”

Section: Phthalates and Neurodevelopmentmentioning

confidence: 99%

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A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Minatoya

Kishi

2021

IJERPH

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Purpose of Review: Bisphenol A and phthalate have been found in the environment, as well as in humans. In this narrative review pre- and postnatal bisphenol A and phthalate exposures, their relationship to neurodevelopment, and the behavioral outcomes of children are elucidated, focusing in particular on the recent case-control, cross-sectional, and longitudinal studies. This review also introduces some of the possible mechanisms behind the observed associations between exposures and outcomes. Recent Findings: Although bisphenol A and phthalate exposure have been reported to influence neurobehavioral development in children, there are various kinds of test batteries for child neurodevelopmental assessment at different ages whose findings have been inconsistent among studies. In addition, the timing and number of exposure assessments have varied. Summary: Overall, this review suggests that prenatal exposure to bisphenol A and phthalates may contribute to neurobehavioral outcomes in children. The evidence is still limited; however, Attention Deficit Hyperactivity Disorder (ADHD) symptoms, especially among boys, constantly suggested association with both prenatal and concurrent exposure to bisphenol A. Although there is limited evidence on the adverse effects of prenatal and postnatal bisphenol A and phthalate exposures provided, pregnant women and young children should be protected from exposure based on a precautionary approach.

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Section: Phthalates and Neurodevelopmentmentioning

confidence: 80%

Section: Phthalates and Neurodevelopmentmentioning

confidence: 99%

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Minatoya

Kishi

2021

IJERPH

View full text Add to dashboard Cite

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“…Epidemiologic studies suggest that intrauterine phthalate exposure is linked to neurodevelopmental delay in early childhood (one year to school age), including cognitive and behavioral function [ 20 , 21 , 22 , 23 ]. However, findings are not fully conclusive and limited overlap exists across the neurodevelopmental domains assessed.…”

Section: Introductionmentioning

confidence: 99%

Gestational Exposure to Phthalates and Phthalate Replacements in Relation to Neurodevelopmental Delays in Early Childhood

Park

Zimmerman

Huerta-Montañez

et al. 2023

Toxics

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Phthalates have been linked to changes in child neurodevelopment. However, sex-specificity has been reported inconsistently, and little is known about the impact of recent phthalate replacement chemicals. Our analysis included mother–child pairs (N = 274) from the PROTECT birth cohort in Puerto Rico. Phthalate metabolites were measured in multiple maternal urine collected during pregnancy. Neurodevelopment was measured at 6, 12, and 24 months of age using the Battelle Developmental Inventory-2nd edition (BDI), which provides scores for adaptive, personal-social, communication, motor, and cognitive domains. Multivariable linear regression was used to examine associations between phthalate metabolite concentrations and BDI scores, adjusting for maternal age, maternal education, child age, and specific gravity. Sex-specificity was assessed with sex X exposure interaction terms and stratified models. Results show that all five domains were significantly associated with mono-3-carboxypropyl phthalate (MCPP) at age 24 months, suggesting a holistic developmental delay related to this metabolite. Sex-specificity existed for all timepoints (p-interaction < 0.2), in general, showing stronger associations among boys. For example, metabolites of a recent phthalate replacement, di-2-ethylhexyl terephthalate (DEHTP), were differentially associated with the adaptive domain (boys −7.53%/IQR, 95% CI: −14.58, −0.48 vs. girls −0.85%/IQR, 95% CI: −5.08, 3.37), and the cognitive domain (boys −6.05%/IQR, 95% CI: −10.88, −1.22 vs. girls −1.93%/IQR, 95%CI: −4.14, 0.28) at 6 months. To conclude, gestational exposure to phthalates and phthalate replacements was associated with neurodevelopmental delay across multiple domains, with differences by sex and child age.

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“…Although the adverse effects of phthalate levels on children's neurodevelopment have been previously reported (Jankowska, Polańska et al 2019, Daniel, Balalian et al 2020. However, most studies have only focused on the effects of exposure to a single phthalate, whereas human beings are usually exposed to multiple phthalates simultaneously, and phthalates may have joint effect in human body.…”

Section: Introductionmentioning

confidence: 99%

Gender-specific effects of prenatal mixed exposure to multiple serum phthalates on neurodevelopment of children aged 2-3 years ： the Guangxi Birth Cohort Study

Yang

Zheng

et al. 2022

Preprint

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Phthalates have been shown to have adverse effects on neurodevelopment, which may be gender-specific. However, the association between prenatal mixed exposure to phthalates and children's neurodevelopment remain limited. We measured prenatal phthalate levels and children's neurodevelopment. Logistic regression was fitted to examine the association. Among boys, mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP) has adverse effects on gross motor (OR: 7.39, 95% CI:1.42, 38.5). For gross motor in boys, joint effect was discovered between mono-2-ethylhexyl phthalate (MEHP) and MEHHP. Moreover, synergistic effects were found for MEHP with vanadium and cadmium, and antagonistic effects for MEHP with magnesium, calcium, titanium, iron, copper, selenium, rubidium and strontium. We did not find statistically significant relationships in girls. In the 1st trimester, adverse effects were identified between mono-2-ethyl-5-oxoyhexyl phthalate (MEOHP) and adaptation ( P = 0.024), and monomethyl phthalate (MMP) with social area ( P = 0.016). In the 2nd trimester, the risk of social development increased with MEHHP. In summary, we found boys may be more vulnerable to the neurotoxicity than girls in gross motor, and the 1st and 2nd trimester might be more sensitive in terms of phthalates on children. To some extent, supplementation of the appropriate metals in the 1st trimester may reduce or inhibit the absorption of phthalates by the foetus, especially in males, so as to prevent neurodevelopmental impairment.

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Phthalate exposure and neurodevelopmental outcomes in early school age children from Poland

Cited by 27 publications

References 46 publications

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Gestational Exposure to Phthalates and Phthalate Replacements in Relation to Neurodevelopmental Delays in Early Childhood

Gender-specific effects of prenatal mixed exposure to multiple serum phthalates on neurodevelopment of children aged 2-3 years ： the Guangxi Birth Cohort Study

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