Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence

Xia, Bin; Zhu, Qionghua; Zhao, Yingya; Ge, Wenzhen; Zhao, Yan; Song, Qibin; Zhou, Yuhan; Shi, Huijing; Zhang, Yunhui

doi:10.1016/j.envint.2018.09.001

Cited by 83 publications

(33 citation statements)

References 33 publications

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“…Moreover, emerging evidence suggests that phthalates and BPA can play roles in the development of metabolic pathologies, from obesity to type 2 diabetes [42,43], in particular promoting adipogenesis [44] via peroxisome proliferator-activated receptor gamma [45]. In studies performed on mixtures of different chemicals, a more defined role for MnBP [46], MEP and BPA [47] emerged. Particularly for BPA the scientific debate was very broad [48,49], with controversial opinions, especially for epidemiological evidences, even if significant associations between BPA exposure and general abdominal obesity and metabolic diseases were substantial [50,51].…”

Section: Introductionmentioning

confidence: 99%

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Caporossi

Alteri

Campo

et al. 2020

IJERPH

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Among the possible risk factors for male reproduction, exposure to phthalates and alkylphenols is widely documented. This study evaluated the possible association between chemical exposure and the quality of the seminal fluid of 105 subjects in a fertility clinic. The urinary levels of seven phthalate metabolites (monoethylphthalate, MEP; monobenzylphthalate, MBzP; mono n-butylphthalate, MnBP; mono-(2-ethylhexyl) phthalate, MEHP; mono(2-ethyl-5-hydroxyhexyl) phthalate, MEHHP; mono-n-octylphthalate, MnOP; mono-isononylphthalate, MiNP) and bisphenol A (BPA), were analysed by high performance liquid chromatography/tandem mass spectrometry HPLC/MS/MS. The regression analysis showed that the semen volume was positively associated with MnBP, MnOP and BPA levels while was negatively associated with MiNP levels. The sperm concentration had a significant inverse relationship with MEP levels. A negative association was found between the use of plastic containers for food storage (p = 0.037) and semen volume (3.06 vs. 2.30 mL as average values, never vs daily). A significant positive correlation emerged (p < 0.005) between the consumption of canned food and the levels of BPA (2.81 vs. 0.14 µg/g creat as average values, daily vs. never) and between the use of perfumes and levels of MEP (389.86 vs. 48.68 µg/g creat, as average values, daily vs. never). No further statistically significant associations were found, even considering the working activity. Some evidence emerged about the possible link between exposure and seminal fluid quality: further case/control or prospective studies will allow us to confirm this causality hypothesis.

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Section: Introductionmentioning

confidence: 99%

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Caporossi

Alteri

Campo

et al. 2020

IJERPH

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“…Deierlein showed that phthalatesspecifically low-molecular weight phthalates (monoethyl phthalate [MEP], a metabolite of diethyl phthalate (DEP); mono-n-butyl phthalate [MBP], a metabolite of di-n-butyl phthalate (DBP), and mono-isobutyl phthalate [MiBP], a metabolite of di-isobutyl phthalate (DiBP))had slight associations with girls' anthropometric outcomes [11]. These substances are readily present in our daily lives, since consumer products usually use parabens as preservatives, building and food packaging materials use phthalates as plasticizers, and the production of pharmaceutical and agricultural products uses 2,5-DCP as a chemical intermediate [12][13][14]. We can easily contact these environmental endocrine-disrupting chemicals via gastrointestinal intake, dermal contact, and applying products that contain these chemicals [15,16].…”

Section: Introductionmentioning

confidence: 99%

Using three statistical methods to analyze the association between exposure to 9 compounds and obesity in children and adolescents: NHANES 2005-2010

Jiang

Jin

et al. 2020

Environ Health

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Background: Various risk factors influence obesity differently, and environmental endocrine disruption may increase the occurrence of obesity. However, most of the previous studies have considered only a unitary exposure or a set of similar exposures instead of mixed exposures, which entail complicated interactions. We utilized three statistical models to evaluate the correlations between mixed chemicals to analyze the association between 9 different chemical exposures and obesity in children and adolescents. Methods: We fitted the generalized linear regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) to analyze the association between the mixed exposures and obesity in the participants aged 6-19 in the National Health and Nutrition Examination Survey (NHANES) 2005-2010. Results: In the multivariable logistic regression model, 2,5-dichlorophenol (2,5-DCP) (OR (95% CI): 1.25 (1.11, 1.40)), monoethyl phthalate (MEP) (OR (95% CI): 1.28 (1.04, 1.58)), and mono-isobutyl phthalate (MiBP) (OR (95% CI): 1.42 (1.07, 1.89)) were found to be positively associated with obesity, while methylparaben (MeP) (OR (95% CI): 0.80 (0.68, 0.94)) was negatively associated with obesity. In the multivariable linear regression, MEP was found to be positively associated with the body mass index (BMI) z-score (β (95% CI): 0.12 (0.02, 0.21)). In the WQS regression model, the WQS index had a significant association (OR (95% CI): 1.48 (1.16, 1.89)) with the outcome in the obesity model, in which 2,5-DCP (weighted 0.41), bisphenol A (BPA) (weighted 0.17) and MEP (weighted 0.14) all had relatively high weights. In the BKMR model, despite no statistically significant difference in the overall association between the chemical mixtures and the outcome (obesity or BMI z-score), there was nonetheless an increasing trend. 2,5-DCP and MEP were found to be positively associated with the outcome (obesity or BMI z-score), while fixing other chemicals at their median concentrations.

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“…The elevated concentrations of citrulline, proline and creatine, which are products of arginine and proline metabolism, implying the increase of amino acid utilization. Relevant metabolic articles indicated that disturbed metabolism of arginine and proline might play an important role in the obesity progression [33,34], in complete agreement with the increase in body weight and liver weight of Landes geese.…”

Section: Discussionmentioning

confidence: 54%

A Serum Metabolic Profiling Analysis During the Formation of Fatty Liver in Landes Geese via Gc-tof/ms

Gong

Lyu

Shi

et al. 2020

Preprint

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Background:During the process of fatty liver production by overfeeding, the levels of endogenous metabolites in the serumof geese would change dramatically. This study investigated the effects of overfeeding on serum metabolism of Landes geese and the underlying mechanisms using a metabolomics approach.Results:Sixty Landes geese of the same age were randomly divided into the following 3 groups: D0 group (free from gavage); D7 group (overfeeding for 7 days); D25 group (overfeeding for 25 days). The results showed that overfeeding significantly increased the body weight and the liver weight of geese. Serum enzymatic activities and serum lipid levels were significantly enhanced following overfeeding.Gas chromatography time-of-flight/massspectrometry (GC-TOF/MS) was employed to explore the serum metabolic patterns, and to identify potential contributors to the formation of fatty liver and the correlatedmetabolic pathways. A large number of endogenous molecules in serum were altered, especially at the late stage of overfeeding (7 days to 25 days). Continuous elevated levels of pyruvic acid, alanine, proline and beta-glycerophosphoric acid and reduced lactic acid level were observed in the serum of overfed geese. Pathway exploration found that the most of significantly different metabolites were involved in various amino acids metabolism, carbohydrate metabolismand lipid metabolism.Conclusions: These findings pinpoint specific metabolite changes and identify potential biomarkers for early diagnosis of fatty liver disease, as well as provide insights into the perturbation of metabolic pathways involved in fatty liver formation.

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Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence

Cited by 83 publications

References 33 publications

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Using three statistical methods to analyze the association between exposure to 9 compounds and obesity in children and adolescents: NHANES 2005-2010

A Serum Metabolic Profiling Analysis During the Formation of Fatty Liver in Landes Geese via Gc-tof/ms

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