Phthalate esters and semen quality parameters

Murature, Domingo A.; Tang, Stephen; Steinhardt, George F.; Dougherty, Ralph C.

doi:10.1002/bms.1200140815

Cited by 72 publications

(31 citation statements)

References 45 publications

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“…In conjunction with this are reports that indicate a significant decrease in the quality of human semen [2][3][4] . It is estimated that male-related disorders are probably present in up to 40% to 50% of childless couples, alone or in combination with female factors [5,6] .…”

Section: Introductionmentioning

confidence: 74%

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Umosen

Ambali

Ayo

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 74%

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Umosen

Ambali

Ayo

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…A substantial proportion of the limited human studies on phthalates and reproductive effects in adults have been focused on investigating associations with altered semen quality. In an early study, Murature et al (1987) measured DBP concentrations in the cellular fractions of ejaculates from 21 university students and found an inverse relationship with sperm concentration. The study had a number of limitations, including a small number of participants, the failure to adjust for potential confounders and measurement of the parent compound, which may be subject to sample contamination.…”

Section: Phthalates (A) Exposurementioning

confidence: 99%

Phthalates and other additives in plastics: human exposure and associated health outcomes

Meeker

Sathyanarayana

Swan

2009

Phil. Trans. R. Soc. B

672

410

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Concern exists over whether additives in plastics to which most people are exposed, such as phthalates, bisphenol A or polybrominated diphenyl ethers, may cause harm to human health by altering endocrine function or through other biological mechanisms. Human data are limited compared with the large body of experimental evidence documenting reproductive or developmental toxicity in relation to these compounds. Here, we discuss the current state of human evidence, as well as future research trends and needs.Because exposure assessment is often a major weakness in epidemiological studies, and in utero exposures to reproductive or developmental toxicants are important, we also provide original data on maternal exposure to phthalates during and after pregnancy (n ¼ 242). Phthalate metabolite concentrations in urine showed weak correlations between pre-and post-natal samples, though the strength of the relationship increased when duration between the two samples decreased. Phthalate metabolite levels also tended to be higher in post-natal samples.In conclusion, there is a great need for more human studies of adverse health effects associated with plastic additives. Recent advances in the measurement of exposure biomarkers hold much promise in improving the epidemiological data, but their utility must be understood to facilitate appropriate study design.

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“…Recent reports have suggested that semen quality has declined during the past 50 years (8)(9)(10)(11)(12)(13)(14)(15). However, these studies examined predominantly groups of selected individuals such as semen donors (10), candidates for vasectomy (8), or patients from infertility clinics (11)(12)(13)15).…”

Section: Semen Qualitymentioning

confidence: 99%

Evidence for Increasing Incidence of Abnormalities of the Human Testis: A Review

Giwercman¹,

Carlsen²,

Keiding³

et al. 1993

Environmental Health Perspectives

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Recent reports have suggested that the incidence of genitourinary abnormalities in human males has increased during the past 50 years, including congenital abnormalities such as cryptorchidism and hypospadia, which seem to be occurring more commonly. Also, the incidence of testicular cancer has increased 3-to 4-fold since the 1940s. This increase seems to be worldwide including countries with a very high frequency of testicular neoplasia as well as those in which this cancer is rather uncommon. It has also been postulated that semen quality has been decreasing for the last half century. A recent study showed that the average sperm density has decreased significantly from 113 million/mL in 1940 to 66 million/mL in 1990. The mean seminal volume has also declined, indicating that the decrease in the total sperm count is even more pronounced than the fall in sperm density would indicate. The remarkable increase in frequency of testicular abnormalities over a relatively short period of time may be due to environmental rather than genetic factors. There is an epidemiological link between the occurrence of different testicular abnormalities. Therefore, common prenatally acting etiological factors with adverse effects on the fetal male gonad might be suspected. However, postnatal influences may also have a deleterious effect on male fertility. From the reproductive point of view, an increased impact on the human male gonad is of concern.

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Phthalate esters and semen quality parameters

Cited by 72 publications

References 45 publications

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Phthalates and other additives in plastics: human exposure and associated health outcomes

Evidence for Increasing Incidence of Abnormalities of the Human Testis: A Review

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