Phthalate drives splenic inflammatory response via activating HSP60/TLR4/NLRP3 signaling axis-dependent pyroptosis

Ge, Xin-Ran; Zhao, Yi; Ren, Hao-Ran; Jiang, Fu-Wei; Liu, Shuo; Lou, Ming; Huang, Yi-Feng; Chen, Ming-Shan; Wang, Jia-Xin; Li, Jin-Long

doi:10.1016/j.envpol.2024.123610

Environmental Pollution

2024

DOI: 10.1016/j.envpol.2024.123610

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Phthalate drives splenic inflammatory response via activating HSP60/TLR4/NLRP3 signaling axis-dependent pyroptosis

Xin-Ran Ge,

Yi Zhao,

Hao-Ran Ren

et al.

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Cited by 1 publication

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Molecular Chaperonin HSP60: Current Understanding and Future Prospects

Singh,

Shin,

Han

et al. 2024

IJMS

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Molecular chaperones are highly conserved across evolution and play a crucial role in preserving protein homeostasis. The 60 kDa heat shock protein (HSP60), also referred to as chaperonin 60 (Cpn60), resides within mitochondria and is involved in maintaining the organelle’s proteome integrity and homeostasis. The HSP60 family, encompassing Cpn60, plays diverse roles in cellular processes, including protein folding, cell signaling, and managing high-temperature stress. In prokaryotes, HSP60 is well understood as a GroEL/GroES complex, which forms a double-ring cavity and aids in protein folding. In eukaryotes, HSP60 is implicated in numerous biological functions, like facilitating the folding of native proteins and influencing disease and development processes. Notably, research highlights its critical involvement in sustaining oxidative stress and preserving mitochondrial integrity. HSP60 perturbation results in the loss of the mitochondria integrity and activates apoptosis. Currently, numerous clinical investigations are in progress to explore targeting HSP60 both in vivo and in vitro across various disease models. These studies aim to enhance our comprehension of disease mechanisms and potentially harness HSP60 as a therapeutic target for various conditions, including cancer, inflammatory disorders, and neurodegenerative diseases. This review delves into the diverse functions of HSP60 in regulating proteo-homeostasis, oxidative stress, ROS, apoptosis, and its implications in diseases like cancer and neurodegeneration.

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Molecular Chaperonin HSP60: Current Understanding and Future Prospects

Singh,

Shin,

Han

et al. 2024

IJMS

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show abstract

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Phthalate drives splenic inflammatory response via activating HSP60/TLR4/NLRP3 signaling axis-dependent pyroptosis

Cited by 1 publication

References 61 publications

Molecular Chaperonin HSP60: Current Understanding and Future Prospects

Molecular Chaperonin HSP60: Current Understanding and Future Prospects

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