Phototoxicity of Quinolones: Measurement by UV-A Inhibition of Concanavalin A-Stimulated Lymphocyte Mitogenic Response

Shimizu, Tadayori; Imagawa, Takayuki; Asai, Y; Iwamoto, Yoshihisa; Kitagawa, Toshiro; Uno, Katsuji; Yanagihara, Yasutake

doi:10.1007/bf02348759

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1997

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“…Moreover, the spectral changes of quinolones under UVA irradiation were related to the inhibition rate of lymphocyte mitogenic activity under stimulation by concanavalin A (Shimizu et al, 1995). In the present study, however, UVA-preirradiated SPFX did not increase PGE2 concentration in the culture medium of 3T3 cells, corresponding to the result of the previous report that intraauricular injection of UVA-irradiated quinolone did not induce skin inflammation (Wagai and Tawara, 1991).…”

Section: Discussionsupporting

confidence: 84%