Phototoxicity from furocoumarins (psoralens) of <i>Heracleum laciniatum</i> in a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin

Kavli, G; Midelfart, K.; Raa, Jan; Volden, G

doi:10.1111/j.1600-0536.1983.tb04429.x

Cited by 27 publications

(15 citation statements)

References 5 publications

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“…The action spectrum for bergamot oil or bergapten in this study is in good accordance with their data for 8-MOP. In the previous studies (9,10), the action spectrum for bergapten phototoxicity was determined by evaluation of skin erythema induced 48-72 h after irradiation. Their action spectrum for phototoxicity was in the range of 320-370 nm with a peak at 330-340 nm.…”

Section: Discussionmentioning

confidence: 99%

Action Spectrum for Bergamot‐Oil Phototoxicity Measured by Sunburn Cell Counting

Yasui

Hirone

1994

The Journal of Dermatology

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The present study investigated the phototoxic effect of bergamot oil and its photosensitive component, bergapten, on sunburn cell (SBC) production in guinea pig skin. The back skin was pretreated with bergamot oil or bergapten and exposed to monochromatic light under various conditions. After irradiation, skin specimens were excised, and histological sections were prepared. The number of sunburn cells in the interfollicular epidermis was counted. The SBC formation by bergamot oil or bergapten plus UVB radiation was the same as that without pretreatment with any photosensitizer. In contrast, a significant number of SBCs were induced by bergamot oil or bergapten plus UVA radiation, but no SBCs were found after the treatment with UVA alone. The result indicates that bergamot oil or bergapten was photosensitized by UVA irradiation. The SBCs were linearly increased in a UV-dose dependent manner. On the basis of the regression lines, an action spectrum and spectral peak for the photosensitizers plus UVA were obtained. The action spectrum for bergamot oil- and bergapten-induced SBC formation was in the ranges of 325-365 nm and 325-350 nm, and their spectral peaks were at 335-345 nm and 335-350 nm, respectively. The data are in good accordance with those estimated from skin erythema reactions. Therefore, counting SBCs is a very useful parameter for quantitative evaluation of phototoxicity.

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Section: Discussionmentioning

confidence: 99%

Action Spectrum for Bergamot‐Oil Phototoxicity Measured by Sunburn Cell Counting

Yasui

Hirone

1994

The Journal of Dermatology

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“…Ammi majus [24] Angelica archangelica [300] Heracleum laciniatum [273] Pimpinella saxifraga [301] Isobergaptol …”

Section: Apiaceaementioning

confidence: 99%

Furanocoumarins

Rı́o¹,

Díaz²,

García‐Bernal³

et al. 2014

Studies in Natural Products Chemistry

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“…Heracleum laciniatum Hornem.) [307], giant hogweed (Heracleum mantegazzianum Somm. and Lev) [55,297], and hogweed (Heracleum sphondylium L.) [308].…”

Section: Ranunculaceae (Buttercup Family)mentioning

confidence: 99%