Phototoxicity assessment of drugs and cosmetic products using E. coli

Verma, K.; Agrawal, N K; Misra, R.B.; Farooq, Muhammad; Hans, R.K.

doi:10.1016/j.tiv.2007.08.009

Cited by 9 publications

(2 citation statements)

References 38 publications

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“…The positive control for phototoxicity, 8methoxypsoralen resulted in the appearance of growth inhibition halo in the irradiated plates (figure 5); and octyl p-methoxycinnamate did not promote the appearance of growth inhibition halo. It is particularly important to test the phototoxic potential of pharmaceuticals and cosmetic products because the photoexcited forms of certain chemical compounds are known to produce phototoxic insult to cellular biomolecules [45].…”

Section: Phototoxicity In Vitromentioning

confidence: 99%

Novel ultraviolet absorbers derived from cashew nut shell liquid: spectrophotometric, in silico and in vitro assays

Araújo

Romeiro²,

Rodrigues³

et al. 2020

Drug Anal. Res.

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The cashew nut shell liquid (CNSL) constituents were isolated by our group leading to four mixtures and seventeen pure compounds, which had chromophoric groups similar to organic ultraviolet (UV) absorbers. In addition, C15 and C8 CNSL-derivatives molecules were rationally planned as UV absorbers. Mixtures and isolated CNSL compounds were demonstrated to be non-phototoxic when evaluated in a phototoxicity assay using the yeast Saccharomyces cerevisiae. Considering the absorption values on the UV range, 6 compounds showed appropriate SPF values regarding the spectrophotometric test. Additionally, in silico and in vitro evaluations were performed, showing non-oral bioavailability, as well as non-mutagenic, non-genotoxic and non-phototoxic properties for the tested compounds. These results contribute favorably to the aimed use of the compounds under analysis as novel organic UV absorbers that have as precursor the phenolic lipid component of CNSL, a waste product obtained as the by-product of cashew nut food processing.

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Section: Phototoxicity In Vitromentioning

confidence: 99%

Novel ultraviolet absorbers derived from cashew nut shell liquid: spectrophotometric, in silico and in vitro assays

Araújo

Romeiro²,

Rodrigues³

et al. 2020

Drug Anal. Res.

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“…Natural and synthetic chemicals can become toxic as a result of absorbtion of photons. Perception of phototoxic hazards to biological system is increasing predominantly due to expanding use of chemicals in agriculture, industry, medicine and the concomitant exposure to ultraviolet radiation [2].…”

Section: Introductionmentioning

confidence: 99%

The quality control of some dermo-cosmetic products

Popescu

Soceanu

Dobrinaș

2014

Analele Universitatii "Ovidius" Constanta - Seria Chimie

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This paper refers to the quality analysis of three dermo-cosmetic products: two face creams and a biphasic solution used for skin cleaning: a treatment cream for acne complexion, an anti-irritating soothing cream and a matifying purifying lotion. The following characteristics have been investigated: aspect, smell, colour, solubility, type of emulsion, stability test at certain temperatures (4°C and 40°C), pH, melting point, water, volatile substances and total fats contents, acidity, ester index, saponification index, iodine index, peroxide index, microbic carriage, metal traces (determined by ICP-MS method). All analysed dermo-cosmetic products have appropriate physico-chemical characteristics. The analyses made for determining the microbial charge have proven that the three dermo-cosmetic products do not contain any aerobic pathogen germens or micromicetes, Staphylococcus aureus and Escherichia Coli. The ICP-MS analysis has proven that the dermocosmetic products do not contain traces of Hg and Pb.

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Alternatives toIn vivoStudies in Toxicology

Gad

2009

General, Applied and Systems Toxicology

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Toxicology or its appplied product evaluation function (also called safety assessment) has now been in the forefront of the public's interest and expectations since at least the Second World War. As our understanding increased, a range of test designs and experimental methods using intact higher animals rapidly developed and came to be accepted in regulation and law. However, as we have come to understand more of both how biological systems work and of the molecular and cellular mechanisms that underlie specific toxicities, we have also come to understand that intact higher animals may not be the only model system that allows us to identify and evaluate adverse effects resulting from exposure to a drug or chemical. Since the early 1980s, this has lead to extensive efforts to develop and validate non‐animal methods. And to use these to the extent possible to take the place of intact animals in the identification and evaluation of hazards for regulatory purposes. This chapter seeks to capture the current breadth and status of that journey.

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Phototoxicity assessment of drugs and cosmetic products using E. coli

Cited by 9 publications

References 38 publications

Novel ultraviolet absorbers derived from cashew nut shell liquid: spectrophotometric, in silico and in vitro assays

Novel ultraviolet absorbers derived from cashew nut shell liquid: spectrophotometric, in silico and in vitro assays

The quality control of some dermo-cosmetic products

Alternatives toIn vivoStudies in Toxicology

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