Phototoxic Effect of Visible Blue Light on Aggregatibacter Actinomycetemcomitans and Porphyromonas Gingivalis in Patients with Chronic Periodontitis : An in - Vitro Study

AbdulAzeez, Ali Raad; Mahmood, Maha Sh.; Ali, Wifaq M.

doi:10.12816/0015279

Cited by 4 publications

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“…intermedia are black pigmented anaerobes, both of which have been found to accumulate the endogenous porphyrins, dimeric protoporphyrin IX and monomeric protoporphyrin IX. These endogenous porphyrins have a strong absorption peak at approximately 400 nm which corresponds to blue light, and numerous studies have shown that upon irradiation with blue light, both of these pathogens can be photoinactivated in the absence of an exogenous photosensitiser (Soukos et al 2005, Hope et al 2013, AbdulAzeez et al 2014. Whilst those studies focused on blue light, which strongly activates these endogenous porphyrins, there is a smaller absorption peak at approximately 600-700 nm, corresponding to the red light which was utilized in our study.…”

Section: Discussionmentioning

confidence: 89%

Light activated antimicrobial agents can inactivate oral malodour causing bacteria

et al. 2016

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Oral malodour is a common condition which affects a large proportion of the population, resulting in social, emotional and psychological stress. Certain oral bacteria form a coating called a biofilm on the tongue dorsum and degrade organic compounds releasing volatile sulfur compounds that are malodourous. Current chemical treatments for oral malodour such as mouthwashes containing chlorhexidine or essential oils, are not sufficiently effective at reducing the bacterial load on the tongue. One potential alternative to current chemical treatments for oral malodour is the use of light activated antimicrobial agents (LAAAs), which display no toxicity or antimicrobial activity in the dark, but when exposed to light of a specific wavelength produce reactive oxygen species which induce damage to target cells in a process known as photodynamic inactivation. This study aimed to determine whether oral malodour causing bacteria were susceptible to lethal photosensitization. Five bacterial species that are causative agents of oral malodour were highly sensitive to lethal photosensitization and were efficiently killed by methylene blue in conjunction with 665 nm laser light. Between 4.5-5 log reductions in the number of viable bacteria were achieved with 20 µM methylene blue and 14.53 J cm laser light for Porphyromonas gingivalis, Prevotella intermedia, Peptostreptococcus anaerobius and Solobacterium moorei. The number of viable cells fell below the limit of detection in the case of Fusobacterium nucleatum. These findings demonstrate that methylene blue in combination with 665 nm laser light is effective at killing bacteria associated with oral malodour, suggesting photodynamic therapy could be a viable treatment option for oral malodour.

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Section: Discussionmentioning

confidence: 89%

Light activated antimicrobial agents can inactivate oral malodour causing bacteria

et al. 2016

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“…Periodontal diseases are known to be caused by several pathogenic bacteria such as (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia ...etc.) and manifests itself as inflammatory process that is either confined to the gingiva namely gingivitis, or extends to the underlying supporting apparatus to be known as periodontitis [7,20]. inflammatory mediators [21] such as PGE2 which was isolated from the gingival crevicular fluid and saliva of pregnant women in their 7 th and 8 th month of pregnancy [22].…”

Section: Discussionmentioning

confidence: 99%

Impact of maternal periodontal health on fetus weight in Iraqi pregnant women: a clinical study

ABDULAZEEZ,

KADHUM,

ALI

2023

Braz. Dent. Sci.

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Objective: the aim of this study was to investigate the relationship between periodontal health condition and the weight of fetuses in Iraqi pregnant women in order to magnify the importance of periodontal health maintenance during pregnancy. Material and Methods: fetus weight was determined using ultrasound scanning for 222 pregnant women, accordingly they were divided into two groups: group A: normal fetus weight and group B: below normal fetal weight. Their periodontal condition was examined by means of Plaque index (PI), Gingival index (GI), Bleeding on probing (BOP) and Clinical Attachment loss (CAL) using WHO CPITN periodontal probe. WHO charts of normal fetal weight for each week were considered to determine the normality of fetus weight. Results: significant value p=0.00 was obtained when comparing the examined periodontal parameters between

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“…It is beyond debate now that, with the exception of congenital and auto-immune problems, the plaque pathogens like P. Gingivalis, Aggregatibacter Actinomycetemcomitans , etc. are the key factor behind periodontal problems, 17 , 18 this is true for peri-implant diseases too 19 starting from simple plaque related gingivitis until more serious conditions such as loss of attachment related periodontitis in its most known form (previously named chronic and acute periodontitis) recently changed into only periodontitis. 20 …”

Section: Introductionmentioning

confidence: 99%

The Crucial Role of Plaque Control in Peri-Implant Mucositis Initiation as Opposed to the Role of Systemic Health Condition: A Cross-Sectional Study

AbdulAzeez

Alkinani

2021

CCIDE

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Purpose The aim of this study was to investigate the priority of periodontal plaque as a risk factor compared to other risk factors, namely hypertension and diabetes mellitus type II, regarding the initiation and severity of peri-implant mucositis, eventually reinforcing the importance of plaque control, periodic maintenance and supportive periodontic treatment after implant placement in order to prevent peri-implant diseases. Patients and Methods A total of 58 patients (84 implants) were enrolled; each individual implant was considered as a separate sample first, then sampling by patient was also applied, implants were divided into group A: systemically healthy patients and B: patients with hypertension and diabetes mellitus type II, the status of peri-implant tissue was followed after the healing abutment placement, with regard to implant mucosal index (IMI), probing pocket depth (PPD) and bleeding on probing (BOP); when sampling was done by patient, the mean of scores of all examined implants in each patient was taken to represent one sample. Results Group A implants showed higher mean scores of PPD (5.2 mm) than group B (4.2 mm) with significance (P = 0.014), and higher mean scores of BOP, group A = 0.71, group B = 0.45 with (P = 0.015); there was no statistical difference with regard to IMI, group A = 1.35, group B = 1.16 with (P = 0.172). Similar results were obtained when the sampling was calculated by patient; PPD: group A (5.31 mm), group B (4.75 mm) and P = 0.008, IMI: group A (1.34), group B (1.16) and P = 0.131, BOP: group A (0.75), group B (0.48) and P = 0.03. Conclusion In the absence of proper plaque control, systemic diseases showed no impact on the initiation and severity of peri-implant mucositis when compared to systemically healthy patients.

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Phototoxic Effect of Visible Blue Light on Aggregatibacter Actinomycetemcomitans and Porphyromonas Gingivalis in Patients with Chronic Periodontitis : An in - Vitro Study

Cited by 4 publications

References 0 publications

Light activated antimicrobial agents can inactivate oral malodour causing bacteria

Light activated antimicrobial agents can inactivate oral malodour causing bacteria

Impact of maternal periodontal health on fetus weight in Iraqi pregnant women: a clinical study

The Crucial Role of Plaque Control in Peri-Implant Mucositis Initiation as Opposed to the Role of Systemic Health Condition: A Cross-Sectional Study

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