Photothermally triggered on-demand insulin release from reduced graphene oxide modified hydrogels

Teodorescu, Florina; Oz, Yavuz; Quéniat, Gurvan; Abderrahmani, Amar; Foulon, Catherine; Lecoeur, Marie; Sanyal, Rana; Sanyal, Amitav; Boukherroub, Rabah; Szunerits, Sabine

doi:10.1016/j.jconrel.2016.10.028

Cited by 72 publications

(66 citation statements)

References 32 publications

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“…These systems are commonly prepared using self-assembly processes and benign conditions in contrast to polymeric gels for which toxic photo-initiators and cross-linkers are employed for their formation. 7,27 We show here that simple mixing of metformin with graphene based derivatives, such as graphene oxide (GO) or carboxylated reduced graphene oxide (rGO-COOH), as cross-linkers in a volume ratio of 1/9 results in metformin gel formation. The gelation process is believed to be driven mainly by hydrogen bonding and electrostatic interactions.…”

Section: Introductionmentioning

confidence: 95%

“…[2][3][4][5] NIR-triggerable drug delivery platforms are largely based on NIR absorbing nanomaterials, notably on reduced graphene oxide (rGO) based matrixes. [6][7][8][9] The effectiveness of rGO as NIRabsorbing photothermal agent compared to other carbon allotropes is due to the rapid light-toheat conversion of rGO under low-power NIR irradiation. This has made rGO preferential filler in polymeric blends and composite hydrogels.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13][14][15] Next to efficient drug delivery, near-infrared light has also been considered as external trigger to enhance transdermal drug delivery. 4,6,7,16,17 Transdermal drug delivery systems are more and more considered for personalized medicine and are a pain free alternative to hypodermic injections. 18,19 In this paper the formulation of light responsive transcutaneous patch, based on gelation between rGO and metformin will be shown as well as its use for the transdermal delivery of metformin.…”

Section: Introductionmentioning

confidence: 99%

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Near-infrared light activatable hydrogels for metformin delivery

Pagneux

Voronova

et al. 2019

Nanoscale

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Drug loaded hydrogels have proven to be versatile controlled-release systems. We report here on heat active hydrogels' formation by mixing graphene oxide (GO) or carboxyl enriched reduced graphene oxide (rGO-COOH) with metformin hydrochloride, an insulin sensitizer drug currently used as first line therapy to treat patients with type 2 diabetes. The driving forces of the gelation process between the graphene-based nanomaterial and metformin are hydrogen bonding and electrostatic interactions, weakened at elevated temperature. Using the excellent photothermal properties of the graphene matrixes, we demonstrate that these supramolecular drug reservoirs can be photothermally activated for transdermal metformin delivery. A sustained delivery of metformin was achieved using a laser power of 1 W cm -2 . In vitro assessment of the key target Glucose-6 Phosphatase (G6P) gene expression using Human hepatocyte model confirmed that metformin activity was unaffected by photothermal activation.In vivo, metformin was detected in mice plasma at 1h post-activation of the metformin loaded rGO-COOH gel.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Near-infrared light activatable hydrogels for metformin delivery

Pagneux

Voronova

et al. 2019

Nanoscale

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“…However, the targeted release of chemotherapeutics alone has also shown some degree of failure [3]. The great photothermal conversion efficacy of graphene nanosheets, notably rGO, makes this material a potential instrument to induce targeted localized hyperthermia as a booster of tumor cell death in combination with radiotherapy [4,5].…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Nanosheets for Localized Hyperthermia—Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death

Podolska

Barras

Frey

et al. 2020

Cells

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Background: The main goals of cancer treatment are not only to eradicate the tumor itself but also to elicit a specific immune response that overcomes the resistance of tumor cells against chemo- and radiotherapies. Hyperthermia was demonstrated to chemo- and radio-sensitize cancerous cells. Many reports have confirmed the immunostimulatory effect of such multi-modal routines. Methods: We evaluated the interaction of graphene oxide (GO) nanosheets; its derivatives reduced GO and PEGylated rGO, with components of peripheral blood and evaluated its thermal conductivity to induce cell death by localized hyperthermia. Results: We confirmed the sterility and biocompatibility of the graphene nanomaterials and demonstrated that hyperthermia applied alone or in the combination with radiotherapy induced much more cell death in tumor cells than irradiation alone. Cell death was confirmed by the release of lactate dehydrogenase from dead and dying tumor cells. Conclusion: Biocompatible GO and its derivatives can be successfully used in graphene-induced hyperthermia to elicit tumor cell death.

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“…Reduced graphene oxide (rGO) nanosheets with restored sp 2 network have most lately shown to be ideally suited for drug-loading-and drug-release-based applications using electrical (1)(2)(3) as well as thermal induced triggers. (4)(5)(6)(7)(8)(9)(10) Although the majority of the aromatic scaffold of rGO is devoid of any functional groups, a few carboxylic acid and alcohol groups are present at the edges and other defect points. This limits the effective functionalization of the rGO through covalent transformations.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Reduced Graphene Oxide via Thiol–Maleimide “Click” Chemistry: Facile Fabrication of Targeted Drug Delivery Vehicles

Oz¹,

Barras

Sanyal³

et al. 2017

ACS Appl. Mater. Interfaces

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Materials based on reduced graphene oxide (rGO) have shown to be amenable to noncovalent functionalization through hydrophobic interactions. The scaffold, however, does not provide sufficient covalent linkage given the low number of reactive carboxyl and alcohol groups typically available on the rGO. The integration of clickable groups, particularly the ones that can undergo efficient conjugation without any metal catalyst, would allow facile functionalization of these materials. This study reports on the noncovalent association of a maleimide-containing catechol (dopa-MAL) surface anchor onto the rGO. Thiol-maleimide chemistry allows thereafter the facile attachment of thiol-containing molecules under ambient metal-free conditions. Although the attachment of glutathione and 6-(ferrocenyl)hexanethiol was used as model thiols, the attachment of a cancer cell targeting cyclic peptide, c(RGDfC), opened the possibility of using the dopa-MAL-modified rGO as a targeted drug delivery system for doxorubicin (DOX). Although free DOX showed to be more effective at killing the human cervical cancer cells (HeLa) over human breast adenocarcinoma cancer cells (MDA-MB-231), the DOX-loaded rGO/dopa-MAL-c (RGDfC) nanostructure showed an opposite effect being notably more effective at targeting and killing the MDA-MB-231 cells. The effect is enhanced upon laser irradiation for 10 min at 2 W cm. The facile fabrication and functionalization to readily obtain a functional material in a modular fashion make this clickable-rGO construct an attractive platform for various applications.

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Photothermally triggered on-demand insulin release from reduced graphene oxide modified hydrogels

Cited by 72 publications

References 32 publications

Near-infrared light activatable hydrogels for metformin delivery

Near-infrared light activatable hydrogels for metformin delivery

Graphene Oxide Nanosheets for Localized Hyperthermia—Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death

Functionalization of Reduced Graphene Oxide via Thiol–Maleimide “Click” Chemistry: Facile Fabrication of Targeted Drug Delivery Vehicles

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