Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells

Lv, Wen; Xia, Huiting; Zhang, Kenneth Yin; Chen, Zejing; Liu, Shujuan; Huang, Wei; Zhao, Qiang

doi:10.1039/c7mh00726d

Cited by 53 publications

(31 citation statements)

References 31 publications

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“…Hydrophilic polyethylene glycol was introduced in the polymer to improve the water solubility and EPR effect. The monomer DMN-acryl has been synthesized according to the previous work [26]. The monomer B1 was synthesized in four steps (See in the Supplementary Material).…”

Section: Resultsmentioning

confidence: 99%

“…As illustrated in Figure 2(e), the absorption spectra of P1 dots displayed a strong absorption at 243 nm and a weak absorption at 689 nm, which were consistent with the absorption of DMN and B1 monomer, respectively. After capture of 1 O 2 , the destruction of conjugated structure of DMN leaded to a sharp decrease at 243 nm in the UV-Vis absorption spectra [26]. In addition, P1 dots and P1-SO dots showed almost the same emission maxima at 730 nm (Figure 2(f)), which was attributed to the luminescence of B1 (see in the Supplementary Material) and negligibly affected by the 1 O 2 loading.…”

Section: Resultsmentioning

confidence: 99%

“…They can trap 1 O 2 yielding endoperoxides (EPOs) and release 1 O 2 upon elevating the temperature, which provides a new and powerful concept in 1 O 2 delivery for the treatment of hypoxic tumors. Till now, only few reports have developed the composite systems by combining EPOs with photothermal reagents (such as gold nanorods) to release 1 O 2 in cancer cells [25, 26]. Although they realized photothermal-triggered oxidative damage of cancer cells in in vitro experiments, the composite structures may result in unpredicted side effects and potential harmful impacts on biological environments during therapy in vivo .…”

Section: Introductionmentioning

confidence: 99%

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De Novo Design of Polymeric Carrier to Photothermally Release Singlet Oxygen for Hypoxic Tumor Treatment

Huang

Zhao

et al. 2019

Research

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Intratumoral hypoxia extremely limits the clinic applications of photodynamic therapy (PDT). Endoperoxides allow thermally releasing singlet oxygen (1O2) in a defined quantity and offer promising opportunities for oxygen-independent PDT treatment of hypoxic tumors. However, previous composite systems by combining endoperoxides with photothermal reagents may result in unpredicted side effects and potential harmful impacts during therapy in vivo. Herein, we de novo design an all-in-one polymer carrier, which can photothermally release 1O2. The strategy has been demonstrated to effectively enhance the production of 1O2 and realize the photodamage in vitro, especially in hypoxic environment. Additionally, the polymer carrier accumulates into tumor after intravenous injection via the enhanced permeation and retention effects and accelerates the oxygen-independent generation of 1O2 in tumors. The oxidative damage results in good inhibitory effect on tumor growth. Realization of the strategy in vivo paves a new way to construct photothermal-triggered oxygen-independent therapeutic platform for clinical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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De Novo Design of Polymeric Carrier to Photothermally Release Singlet Oxygen for Hypoxic Tumor Treatment

Huang

Zhao

et al. 2019

Research

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“…The phototherapy agent PPAIB and its precursor P1 were synthesized easily via radical polymerization (Scheme S1, Supporting Information) . They have been fully characterized through nuclear magnetic resonance (NMR) spectra, gel permeation chromatography (GPC), UV–vis absorption spectra, and emission spectra.…”

Section: Resultsmentioning

confidence: 99%

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy

Zhao

Xie

Jun-gu

et al. 2019

Adv Healthcare Materials

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of tumor. [7][8][9] Thus, SPT could exhibit the synergistic effect of "1 + 1 > 2" in theory. However, the effect of PDT would be limi ted severely due to the hypoxic microen vironment in the tumor, leading to that the photothermal effect often dominates the therapy efficiency during the syner gistic therapy process. [10][11][12][13][14][15][16] Thus, tradi tional combination of PTT and PDT failed to fully perform the effect of synergistic phototherapy. Consequently, it is very urgent to develop novel SPT agents which can show the truly synergistic and even enhanced effects of PTT and PDT.Recent works indicated that MnO 2 is a versatile nanocarrier for anticancer treat ment. [13][14][15][16][17] MnO 2 nanostructures have been demonstrated to enhance the anti cancer efficiency through the following three approaches: (1) catalyzing H 2 O 2 to generate O 2 to relieve the hypoxic environ ment in the tumor and enhance the PDT effect, [17,18] (2) generating extra heat to improve the PTT efficiency under irradia tion, [10,21] and (3) reacting with glutathione to reduce the consumption of ROS and release the anticancer drug to enhance the synergistic therapy process. [19,20] Therefore, MnO 2 nanocarriers provide a new insight into design strategies for enhancement of SPT effect. Nevertheless, common strategies to utilize MnO 2 nanocarrier for improving the anticancer effects face with the problems of complicated structures and cumbersome preparation process, because the nanosystems usually contain MnO 2 nanocarrier with various morphologies, phototherapy agents, hydrophilic group, and even some functional groups such as protein and RNA. [21][22][23][24] Therefore, developing MnO 2 nanosystems with simple structures for enhancing the synergistic therapeutic effi ciency is urgent but challenging.In order to construct a simple MnO 2 based nanosystem to realize the truly synergistic and even enhanced effects of PTT and PDT, suitable phototherapeutic agents should be selected. Among numerous phototherapeutic agents, nearinfrared (NIR) azaBODIPY dyes, which exhibit both excellent photo thermal and photodynamic effects, were ideal SPT agent for further application in combination with MnO 2 . [25][26][27][28][29] In parallel, to avoid the complex structure and preparation process of the Recent studies indicate that the synergistic phototherapy (SPT) process can simultaneously generate heat for photothermal therapy (PTT) and singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT) to overcome the recurrence of tumors. However, the hypoxic environment in tumors seriously limits the therapeutic effect of the oxygen-dependent PDT, leading to the domination of PTT in the SPT process. Therefore, it is urgent to develop a novel SPT platform for overcoming hypoxia in tumors and improving the therapeutic effect of both PTT and PDT. In this work, a novel phototherapeutic platform based on a nanocomposite of aza-BODIPY/manganese dioxide (MnO 2 ) is developed via simple electrostatic self-assembly. In this design, MnO 2 nanosheets, which coul...

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“…[22][23][24] It was reported that methylnaphthalenes and anthracenes can be used for cancer cell damage. 12,25 However, the short lifetime made them unable to perform well in cancer treatment. 26 Although some photothermal materials have been used for accelerating ROS release, excessive temperature can also induce damage to normal tissues.…”

Section: Introductionmentioning

confidence: 99%

A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal–Organic Framework for Cancer Therapy

Xie

et al. 2021

CCS Chem

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Here, a methacrylate-modified pyridone derivative (mPYR) was loaded into a porphyrin nanoscale metal-organic framework (porphyrin-nMOF). Then, the loaded mPYR was further polymerized to obtain poly-pyridone (poly-mPYR) to form poly-mPYR loaded porphyrin-nMOF, which is designated as PLP and used as a reservoir of singlet oxygen ( 1 O 2 ). It was found that PLP could quickly capture 1 O 2 in vitro and slowly release 1 O 2 in vivo to induce cancer cell death. The release of 1 O 2 was light and oxygen independent, and the entire process did not cause intracellular oxygen consumption. PLP also displayed good therapeutic effect in the treatment of both solid tumor and lung metastasis cancer. This strategy of oxygenand light-independent 1 O 2 treatment presents great potential for treating refractory cancer. Also, the form of 1 O 2 capturing polymer-loaded nMOF expands the biomedical applications of MOFs and polymers, which can be used as a platform for biomedical applications.

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Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells

Abstract: An endoperoxide-containing polymeric carrier was developed to realize the photothermal-triggered release of singlet oxygen for killing cancer cells.

Cited by 53 publications

References 31 publications

De Novo Design of Polymeric Carrier to Photothermally Release Singlet Oxygen for Hypoxic Tumor Treatment

De Novo Design of Polymeric Carrier to Photothermally Release Singlet Oxygen for Hypoxic Tumor Treatment

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy

A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal–Organic Framework for Cancer Therapy

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Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells

Abstract: An endoperoxide-containing polymeric carrier was developed to realize the photothermal-triggered release of singlet oxygen for killing cancer cells.

Cited by 53 publications

References 31 publications

De Novo Design of Polymeric Carrier to Photothermally Release Singlet Oxygen for Hypoxic Tumor Treatment

De Novo Design of Polymeric Carrier to Photothermally Release Singlet Oxygen for Hypoxic Tumor Treatment

Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO2 for Enhancing Tumor Synergistic Therapy

A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal–Organic Framework for Cancer Therapy

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Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO₂ for Enhancing Tumor Synergistic Therapy