Photothermal-triggered immunogenic nanotherapeutics for optimizing osteosarcoma therapy by synergizing innate and adaptive immunity

Liu, Kaiyuan; Liao, Yuxin; Zhou, Zifei; Zhang, Li; Jiang, Yingying; Lu, Hengli; Xu, Tianyang; Yang, Dong; Gao, Qiuming; Tan, Shuo; Cao, Weiguo; Chen, Feng; Li, Guodong

doi:10.1016/j.biomaterials.2022.121383

Cited by 46 publications

(26 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[144] As shown in Figure 10(c), OVA was effectively released (with release rate > 80 %) under the influence of illumination (NIR laser: 808 nm) for 10 minutes while a slow release rate (< 20 %) after 12 hours was observed for the control sample (at 37 °C) without irradiation. [144] Moreover, the effect of MXenes on bone regeneration was studied by Li et al, in which a hybridized scaffold based on collagen, silk and hydroxyapatite was fabricated and functionalized with Ti 3 C 2 T x MXenes (M-CSH). [145] The bone regeneration performance of the nanocomposite after short-term PTT (10 minutes) was compared with that of a control sample without MXenes (CSH).…”

Section: Cancer Therapymentioning

confidence: 82%

Section: Water Generation and Purificationmentioning

confidence: 99%

“…Recently, Liu et al . prepared an MXene‐based nanoplatform (Ti 3 C 2 T x ‐PEG‐OVA‐Mn 2+ ; OVA: ovalbumin) based on the amide reaction between the amino groups of PEG‐modified Ti 3 C 2 T x and the carboxyl groups of Mn 2+ ‐OVA, and the controllable release of immunogenic antigen (i.e., OVA which could activate T cells by promoting the maturation of dendritic cells) from the nanoplatform by PTT was demonstrated [144] . As shown in Figure 10(c), OVA was effectively released (with release rate >80 %) under the influence of illumination (NIR laser: 808 nm) for 10 minutes while a slow release rate (<20 %) after 12 hours was observed for the control sample (at 37 °C) without irradiation [144] …”

Section: Applications Based On the Thermal Properties Of Mxenesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 4 more Smart Citations

Thermal Properties of MXenes and Relevant Applications

et al. 2022

ChemPhysChem

View full text Add to dashboard Cite

The properties and applications of MXenes (a family of layered transition metal carbides, nitrides, and carbonitrides) have aroused enormous research interests for a decade since the successful synthesis of few‐layer transition metal carbides in 2011. Though MXenes, as the building blocks, have already been applied in various fields (such as wearable electronics) owing to the distinctive optical, mechanical and electrical properties, their thermal stability and intrinsic thermal properties were less thoroughly investigated compared to other characteristics in early reports. The pioneering theoretical prediction of the thermoelectric nature of MXenes was performed in 2013 while the first experiment‐based report concerning the degradation behavior of the 2D structure at elevated temperatures in a controlled atmosphere was published in 2015, followed by numerous discoveries regarding the thermal properties of MXenes. Herein, after a brief description of the synthesis, this Review summarized the latest insights into the thermal stability and thermophysical properties of MXenes, and further associated these unique properties with relevant applications by multiple examples. Finally, current hurdles and challenges in this field were provided along with some advices on potential research directions in the future.

show abstract

Section: Cancer Therapymentioning

confidence: 82%

Section: Water Generation and Purificationmentioning

confidence: 99%

Section: Applications Based On the Thermal Properties Of Mxenesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Thermal Properties of MXenes and Relevant Applications

et al. 2022

ChemPhysChem

View full text Add to dashboard Cite

show abstract

Storable Polydopamine Nanoparticles Combined with Bacillus Calmette‐Guérin for Photothermal‐Immunotherapy of Colorectal Cancer

Zhuang,

Qi,

Huang

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Photothermal immunotherapy emerges as a promising strategy for treating tumors. However, the majority of current photothermal immunotherapy approaches do not yet show significant potential for clinical translation. In this study, lyophilized polydopamine (PDA) nanoparticles combined with Bacillus Calmette–Guérin (BCG) are investigated for photothermal immunotherapy against colorectal cancer. By simply mixing with two lyophilized powders, PDA nanoparticles can covalently bond onto BCG to form BCG@PDA. This combination demonstrates a potent photothermal cytotoxic effect on tumor cells by utilizing PDA nanoparticles. In addition, a heightened immune response triggered by the BCG vaccine, as evidenced by the secretion of important pro‐inflammatory cytokines and the activation of antigen‐presenting cells, is observed. In vivo testing on a murine colon cancer model demonstrates that the combined treatment significantly inhibits tumor growth. Further, the lyophilized PDA nanoparticles can be stored at −20 °C for up to 1 year with stable photothermal properties. Therefore, this study not only presents a reliable method for storing the therapeutic PDA nanoparticles but also demonstrates the potential application of BCG@PDA in photothermal immunotherapy for colorectal cancer.

show abstract

Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell‐Mediated Tumor Immunotherapy

Zhang

Ding

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Traditional dendritic cell (DC)-mediated immunotherapy is usually suppressed by weak immunogenicity in tumors and generally leads to unsatisfactory outcomes. Synergistic exogenous/endogenous immunogenic activation can provide an alternative strategy for evoking a robust immune response by promoting DC activation. Herein, we prepared Ti 3 C 2 MXene-based nanoplatforms (termed MXP) with high-e ciency near-infrared photothermal conversion and immunocompetent loading capacity to form endogenous/exogenous nanovaccines. Speci cally, the immunogenic cell death of tumor cells induced by the photothermal effects of the MXP can generate endogenous danger signals and antigen release to boost vaccination for DC maturation and antigen cross-presentation. In addition, MXP can deliver ovalbumin tumor antigens (OVA) and agonists (CpG-ODN) as an exogenous nanovaccine (MXP@OC), which further enhanced e cient DC activation. Importantly, the synergistic strategy of photothermal therapy and DC-mediated immunotherapy by MXP signi cantly eradicated tumors and enhanced adaptive immunity. Hence, the present work provides a two-pronged strategy for improving immunogenicity and killing tumor cells to achieve a favorable outcome in tumor patients.

show abstract

Photothermal-triggered immunogenic nanotherapeutics for optimizing osteosarcoma therapy by synergizing innate and adaptive immunity

Cited by 46 publications

References 66 publications

Thermal Properties of MXenes and Relevant Applications

Thermal Properties of MXenes and Relevant Applications

Storable Polydopamine Nanoparticles Combined with Bacillus Calmette‐Guérin for Photothermal‐Immunotherapy of Colorectal Cancer

Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell‐Mediated Tumor Immunotherapy

Contact Info

Product

Resources

About