Photothermal therapy (PTT) is an effective treatment measure against solid tumors which fails to respond conventional chemo/radiation therapies in clinic

Mishra, Sumit; Dhadve, Ajit; Mal, Arijit; Reddy, B. Pradeep K.; Hole, Arti; C, Murali Krishna; Ray, Pritha; Srivastava, Rohit; De, Abhijit

doi:10.1016/j.bioadv.2022.213153

Cited by 11 publications

(6 citation statements)

References 46 publications

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“…This study adds a value on the potential influence of PTT for in vivo ablation, the efficacy of which is closely related to PTT dose optimization. 184 As a result, combining PTT and RT has a lot of potential for uncovering the unexplained causes of major illnesses.…”

Section: Combinational Therapies With Gqds and Pttmentioning

confidence: 99%

Photothermal therapy using graphene quantum dots

Dar,

Tabish,

Thorat

et al. 2023

APL Bioengineering

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The rapid development of powerful anti-oncology medicines have been possible because of advances in nanomedicine. Photothermal therapy (PTT) is a type of treatment wherein nanomaterials absorb the laser energy and convert it into localized heat, thereby causing apoptosis and tumor eradication. PTT is more precise, less hazardous, and easy-to-control in comparison to other interventions such as chemotherapy, photodynamic therapy, and radiation therapy. Over the past decade, various nanomaterials for PTT applications have been reviewed; however, a comprehensive study of graphene quantum dots (GQDs) has been scantly reported. GQDs have received huge attention in healthcare technologies owing to their various excellent properties, such as high water solubility, chemical stability, good biocompatibility, and low toxicity. Motivated by the fascinating scientific discoveries and promising contributions of GQDs to the field of biomedicine, we present a comprehensive overview of recent progress in GQDs for PTT. This review summarizes the properties and synthesis strategies of GQDs including top-down and bottom-up approaches followed by their applications in PTT (alone and in combination with other treatment modalities such as chemotherapy, photodynamic therapy, immunotherapy, and radiotherapy). Furthermore, we also focus on the systematic study of in vitro and in vivo toxicities of GQDs triggered by PTT. Moreover, an overview of PTT along with the synergetic application used with GQDs for tumor eradication are discussed in detail. Finally, directions, possibilities, and limitations are described to encourage more research, which will lead to new treatments and better health care and bring people closer to the peak of human well-being.

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Section: Combinational Therapies With Gqds and Pttmentioning

confidence: 99%

Photothermal therapy using graphene quantum dots

Dar,

Tabish,

Thorat

et al. 2023

APL Bioengineering

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“…[7][8][9] At present, the main type of photothermal agents, near-infrared (NIR) absorptive nanomaterials, have been developed for cancer treatment both in vitro and in vivo. 10,11 However, the disadvantages of some photothermal agents, such as poor biological metabolism and high cost of gold nanomaterials, 12,13 and poor dispersion of carbon nanomaterials to induce immune responses, 14 greatly hinder their application in the biomedical eld. At this time, twodimensional (2D) transition metal disuldes (TMDs) provide rich application prospects in biomedicines and other elds due to their strong near-infrared light absorption, high photothermal conversion efficiency, good photothermal stability, strong loading capacity, and low cost.…”

Section: Introductionmentioning

confidence: 99%

Carbon-coated selenium nanoparticles for photothermal therapy in choriocarcinoma cells

Yu,

He,

et al. 2024

RSC Adv.

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“…Photosensitizers convert light energy into molecular vibration energy when exposed to near-infrared (NIR) radiation of a specific wavelength, transferring heat energy to the surrounding environment. Photothermal therapy (PTT) using photosensitizers has been attracting attention as a cancer treatment method in recent years [ 10 , 11 , 12 ]. It entails a photosensitizing substance administered into the lesion and irradiated with highly bio-permeable NIR, which causes a localized increase in temperature, producing an anti-tumor effect.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Cartilage Metabolism in Rats through a Novel Thermal Stimulation Technique with Photosensitizers

Cha,

Nakagawa,

Arai

et al. 2024

IJMS

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Although the moderate thermal stimulation of articular cartilage exerts chondroprotective effects, it is difficult to effectively heat deep articular cartilage with conventional methods. Photosensitizers increase the ambient temperature using near-infrared (NIR) radiation, which has high tissue permeability. We hypothesized that the intra-articular administration of photosensitizers and NIR irradiation would exert a greater heating effect on articular cartilage. We aimed to evaluate the heating effect of this method on cultured chondrocytes and rat knee cartilage. In vitro, we irradiated a photosensitizer-containing medium with NIR and measured changes in the medium temperature, cytotoxicity, and gene expression of heat shock protein (HSP) 70 and aggrecan (ACAN). In vivo, the knee joints of rats treated with photosensitizers were irradiated with NIR, and changes in intra-articular temperature and gene expression were measured, alongside histological analysis. The results showed that the medium and intra-articular temperature were raised to approximately 40 °C with no apparent disruption to articular cartilage or the immunohistochemically enhanced staining of HSP70 in chondrocytes. The gene expression of HSP70 and ACAN was increased in both cultured and articular cartilage. In summary, this method can safely heat joints and enhance cartilage metabolism by inducing HSP70 expression in articular cartilage. It presents a new hyperthermia therapy with effective cartilage protection.

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Photothermal therapy (PTT) is an effective treatment measure against solid tumors which fails to respond conventional chemo/radiation therapies in clinic

Cited by 11 publications

References 46 publications

Photothermal therapy using graphene quantum dots

Photothermal therapy using graphene quantum dots

Carbon-coated selenium nanoparticles for photothermal therapy in choriocarcinoma cells

Enhancing Cartilage Metabolism in Rats through a Novel Thermal Stimulation Technique with Photosensitizers

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