Photothermal Therapy: Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells (Adv. Mater. 23/2019)

Biomaterial-assisted photoimmunotherapy for cancer

“…23 Furthermore, such immune responses induced by phototherapy are able to work in synergy with other immunotherapies including immune checkpoint blockade (ICB), chimeric antigen receptor (CAR)-T cell and cytokine therapy, achieving significantly increased immune response rates and successful therapeutic outcomes. [24][25][26] For photoimmunotherapy, multifunctional biomaterials not only could act as phototherapeutic agents or carriers to promote the efficacy of phototherapy itself, but also can deliver immunostimulatory cargoes such as adjuvants to amplify the anti-tumor immune responses induced by phototherapy. 27 More importantly, the engineered biomaterials also have the ability to deliver and release various immunotherapeutic agents, including antibodies, cytokines and even immune cells, remodeling the microenvironment where immune cells meet cancer cells, antigens, inhibitors or stimulatory signals, and other immune cells.…”

Phototherapy Facilitates Tumor Recruitment and Activation of Natural Killer T cells for Potent Cancer Immunotherapy

“…28−31 Importantly, a recent study showed that PTT treatment increased blood perfusion and secretion of chemokines and cytokines, which facilitated the tumor accumulation and activation of adoptively transferred CAR-T cells for potent antitumor therapy. 32 Inspired by these studies, we asked whether PTT could be utilized to overcome the obstacles that impede the clinical translation of adoptively transferred NKT cells.…”

“…Photothermal therapy (PTT) utilizes hyperthermia to kill tumor cells by converting incident light into heat. − PTT has been shown to trigger antitumor immunity by activating DC, NK, and T cells. − Importantly, a recent study showed that PTT treatment increased blood perfusion and secretion of chemokines and cytokines, which facilitated the tumor accumulation and activation of adoptively transferred CAR-T cells for potent antitumor therapy . Inspired by these studies, we asked whether PTT could be utilized to overcome the obstacles that impede the clinical translation of adoptively transferred NKT cells.…”

NIR-II Dye-Based Multifunctional Telechelic Glycopolymers for NIR-IIa Fluorescence Imaging-Guided Stimuli-Responsive Chemo-Photothermal Combination Therapy

“…Currently, cancer is a leading cause of death worldwide. , Chemotherapy is imperative as a main means of cancer therapy, − but it usually suffers from the limitations of drug resistance, poor therapeutic effect, and severe toxicity . Recently, optical imaging-guided chemo-photothermal combination therapy has emerged as a potential treatment strategy. − Photothermal therapy (PTT) is a harmless and effective therapeutic method − that avoids the problem of anticancer drug resistance and improves the therapeutic efficacies by exerting a synergistic effect with chemotherapy. Optical imaging-guided therapy possesses the merits of noninvasiveness and high sensitivity for personalized, precision treatment, which might provide ideal diagnostic accuracy. − More importantly, both optical imaging and PTT can be achieved by one component, enhancing the simplicity of the system .…”

“…The synthesis of TTQ-TC required only one key step, a Stille coupling reaction, and achieved high yields (78%). The structure of TTQ-TC was characterized using mass spectrometry, 1 H and 13 C NMR spectrum (see Figures S2, S3 and S4 in the Supporting Information). As shown in Figure 1b, the absorption spectrum of TTQ-TC in tetrahydrofuran (THF) presented a main peak at 796 nm with an extinction coefficient of 13.87 L g −1 cm −1 .…”