Photothermal Therapy: Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy (Adv. Biosys. 4/2020)

Abstract

In article number 1900284, Yoann Lalatonne, Claire Wilhelm, and co‐workers assess the photothermal potential of gold nano‐spheres, rods, and raspberries‐like multi‐cores outside cancer cells (extracellular environment) or internalized within (intracellular), evidencing that the bio‐processing of gold nanomaterials can be highly beneficial for cancer therapy.

Ever-Evolving Identity of Magnetic Nanoparticles within Human Cells: The Interplay of Endosomal Confinement, Degradation, Storage, and Neocrystallization

“…Worthy of note, we just mention here that confinement may affect other nanomedicine modalities, such as laser-mediated photothermia. The latter mostly relies on the use of plasmonic gold nanoparticles, and an opposite effect could be observed, with an increased heat generation in the intracellular environment. , In a similar way, the intracellular confinement of magnetic nanoparticles, which are T2-agents (negative contrast agents) due to their high r2 values (transverse relaxivity), is beneficial for magnetic resonance imaging (MRI). When confined in cells, the r1 value of magnetic nanoparticles (longitudinal relaxivity) decreases massively (100-fold or more), while the r2 value only falls by a factor of 2.5, resulting in a remarkable increase in the r2/r1 ratio (almost 10-fold), governing the MRI negative contrast (Figure h) .…”

Green Synthesis of Gold Nanoparticles using Pimenta dioica Leaves Aqueous Extract and Their Application as Photocatalyst, Antioxidant, and Antibacterial Agents

“…Form, size, crystallinity, and structure are all important factors in these applications. Gold nanostructures have been identified in a variety of shapes, including nanocubes [11], nanowires [12], nanoplates [13], nanospheres, nanorods [14], nanopores [15], nanobelts, and odd angled shapes [16]. Many groups of researchers have long been interested in one-dimensional (1D) metallic nanostructures.…”