Photothermal therapy

Zhi, Defu; Yang, Ting; O'Hagan, Justin; Zhang, Shubiao; Donnelly, Ryan F.

doi:10.1016/j.jconrel.2020.06.032

Cited by 384 publications

(234 citation statements)

References 167 publications

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“…This change in the chemical characteristics of IR700 promotes conformational changes and aggregation of APCs that damage the cell membrane, causing weakening and eventually rupture of the cell ( Figure 1 ). NIR-PIT can clearly be distinguished from conventional photodynamic therapy (PDT) or photothermal therapy (PTT), which rely on cytotoxic singlet oxygen and hyperthermia, respectively, and cause non-selective damage to light-exposed cells [ 13 , 14 ]. In addition to direct cancer-cell killing, NIR-PIT rapidly induces immunogenic cell death (ICD) [ 15 , 16 ], which initiates activation of the adaptive immune response, employing dead-cell-associated antigens, including calreticulin (CRT), adenosine triphosphate (ATP), high-mobility group box 1 (HMGB1), heat shock protein (Hsp) 70, and Hsp90 [ 17 , 18 , 19 , 20 ].…”

Section: Nir-pitmentioning

confidence: 99%

Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy

Kato

Wakiyama

Furusawa

et al. 2021

Cancers

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Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment that uses an antibody-photoabsorber (IRDye700DX) conjugate (APC) that is activated by NIR light irradiation. In September 2020, the first APC and laser system were conditionally approved for clinical use in Japan. A major benefit of NIR-PIT is that only APC-bound cancer cells that are exposed to NIR light are killed by NIR-PIT; thus, minimal damage occurs in adjacent normal cells. These early trials have demonstrated that in addition to direct cell killing, there is a significant therapeutic host immune response that greatly contributes to the success of the therapy. Although the first clinical use of NIR-PIT targeted epidermal growth factor receptor (EGFR), many other targets are suitable for NIR-PIT. NIR-PIT has now been applied to many cancers expressing various cell-surface target proteins using monoclonal antibodies designed to bind to them. Moreover, NIR-PIT is not limited to tumor antigens but can also be used to kill specific host cells that create immune-permissive environments in which tumors grow. Moreover, multiple targets can be treated simultaneously with NIR-PIT using a cocktail of APCs. NIR-PIT can be used in combination with other therapies, such as immune checkpoint inhibitors, to enhance the therapeutic effect. Thus, NIR-PIT has great potential to treat a wide variety of cancers by targeting appropriate tumor cells, immune cells, or both, and can be augmented by other immunotherapies.

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Section: Nir-pitmentioning

confidence: 99%

Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy

Kato

Wakiyama

Furusawa

et al. 2021

Cancers

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“…PTT agents are nontoxic and relatively safe to cells. In compare with traditional tumor treatment models including radiotherapy, surgery, and chemotherapy, PTT is attractive because of certain advantages, such as reduced invasiveness and high specificity [ 140 , 141 ]. Nevertheless, tumor cells usually cannot be completely killed by photothermal treatment alone, finally resulting in tumor recurrence [ 142 ].…”

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

Multienzymes activity of metals and metal oxide nanomaterials: applications from biotechnology to medicine and environmental engineering

Alizadeh

Salimi

2021

J Nanobiotechnol

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With the rapid advancement and progress of nanotechnology, nanomaterials with enzyme-like catalytic activity have fascinated the remarkable attention of researchers, due to their low cost, high operational stability, adjustable catalytic activity, and ease of recycling and reuse. Nanozymes can catalyze the same reactions as performed by enzymes in nature. In contrast the intrinsic shortcomings of natural enzymes such as high manufacturing cost, low operational stability, production complexity, harsh catalytic conditions and difficulties of recycling, did not limit their wide applications. The broad interest in enzymatic nanomaterial relies on their outstanding properties such as stability, high activity, and rigidity to harsh environments, long-term storage and easy preparation, which make them a convenient substitute instead of the native enzyme. These abilities make the nanozymes suitable for multiple applications in sensing and imaging, tissue engineering, environmental protection, satisfactory tumor diagnostic and therapeutic, because of distinguished properties compared with other artificial enzymes such as high biocompatibility, low toxicity, size dependent catalytic activities, large surface area for further bioconjugation or modification and also smart response to external stimuli. This review summarizes and highlights latest progress in applications of metal and metal oxide nanomaterials with enzyme/multienzyme mimicking activities. We cover the applications of sensing, cancer therapy, water treatment and anti-bacterial efficacy. We also put forward the current challenges and prospects in this research area, hoping to extension of this emerging field. In addition to therapeutic potential of nanozymes for disease prevention, their practical effects in diagnostics, to monitor the presence of SARS-CoV-2 and related biomarkers for future pandemics will be predicted.

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“…A large number of studies have explored the design and preparation of PTAs with high PCE, excellent photostability and good biocompatibility over the past few years [30]. Some typical nanomaterials that are used as PTAs are summarized in Table 1, together with their characteristics and biomedical applications.…”

Section: Photothermal Agentsmentioning

confidence: 99%

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

Sun

Chen

Sutrisno

et al. 2021

Science and Technology of Advanced Materials

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Photothermal therapy (PTT) has attracted broad attention as a promising method for cancer therapy with less severe side effects than conventional radiation therapy, chemotherapy and surgical resection. PTT relies on the photoconversion capacity of photothermal agents (PTAs), and a wide variety of nanomaterials have been employed as PTAs for cancer therapy due to their excellent photothermal properties. The PTAs are systematically or locally administered and become enriched in cancer cells to increase ablation efficiency. In recent years, PTAs and three-dimensional scaffolds have been hybridized to realize the local delivery of PTAs for the repeated ablation of cancer cells. Meanwhile, the composite scaffolds can stimulate the reconstruction and regeneration of the functional tissues and organs after ablation of cancer cells. A variety of composite scaffolds of photothermal nanomaterials have been prepared to combine the advantages of different modalities to maximize their therapeutic efficacy with minimal side effects. The synergistic effects make the composite scaffolds attractive for biomedical applications. This review summarizes these latest advances and discusses the future prospects.

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Photothermal therapy

Cited by 384 publications

References 167 publications

Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy

Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy

Multienzymes activity of metals and metal oxide nanomaterials: applications from biotechnology to medicine and environmental engineering

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

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