Photothermal therapy as emerging combinatorial therapeutic approach

Rajani, Chitra; Patel, Vruti; Borisa, Pooja; Karanwad, Tukaram; Polaka, Suryanarayana; Kalyane, Dnyaneshwar; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814455-8.00009-8

Cited by 10 publications

(4 citation statements)

References 139 publications

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“…Gold nanoparticles are one of the potential photothermal agents in photothermal therapy. However, the conventionally synthesized and reported gold nanoparticles lack cancer specificity and need separate surface modification (19,28).…”

Section: Resultsmentioning

confidence: 99%

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Kalyane

Polaka

Vasdev

et al. 2022

Photochem & Photobiology

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This investigation reports the quality‐by‐design (QbD) assisted novel templated approach for developing cancer cell‐specific and laser‐activatable nanoseeds (AuraTherm) for targeted photothermal ablation of triple‐negative breast cancer (TNBC). AuraTherm was nanometric in size as characterized by SEM, TEM and particle analysis (80.28 ± 2.56 nm; −21.80 ± 0.17 mV) with hemocompatibility and neutrality towards blood components. AuraTherm showed reversible photothermal effect (ΔT: 37 ± 1.2°C → 49.4 ± 1.5°C; 15 min; 2.4 W cm−2) employing near‐infrared 808 nm laser (NIR‐808). The targeted cytosolic localization led to a significant anticancer activity as evaluated using apoptosis assay, cell cycle analysis, Intracellular ROS generation assay, cellular uptake and receptor binding assay. The NIR‐808 laser‐responsive photothermal ablation of cancer cell was found to be more effective compared to without NIR‐808 laser‐treated counterparts, suggesting the fundamental role of photothermal ablation in the treatment of TNBC.

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Section: Resultsmentioning

confidence: 99%

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Kalyane

Polaka

Vasdev

et al. 2022

Photochem & Photobiology

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“…The affordability and simplicity of graphene oxide (GO) fabrication make it a viable alternative to metal-based nanoparticles. 48 N. Saravanan et al (2021) manufactured nano graphite reinforced composite by a mechanical layup technique and measured its mechanical properties. 49 The measured values indicated improved tensile, impact, and flexural strengths in the presence of 1.5 wt % nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Mechanical properties of polymer matrix/glass fiber composites containing metal/hybrid nanoparticles-an overview

Laila

Narayanan²,

Sindhu³

et al. 2022

High Performance Polymers

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Glass fiber reinforced composite has gained attention from various engineering fields because of its enhanced properties. This paper reviewed the mechanical characteristics, such as tensile strength, flexural strength, hardness number, impact strength, wear percentage, etc., of the composites from different experimental studies performed by various researchers over time; by varying with the weight percentage of different metal and non-metal nanoparticles. The main observation was that the mechanical properties remained optimal at a certain quantity of nanoparticles was added beyond which these characteristics began to decrease. When more than one type of nanoparticle is dispersed, or micro rubber particles are added with a specific type of nanoparticle, the properties are more pronounced than when only a single type of particle is used.

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“…11 PTT is anticipated to achieve nontoxic and potent tumor cell targeting to improve clinical efficiency without harming healthy tissues. 30 Several CNMs exhibiting NIR absorption show remarkable clinical efficacy in numerous in vivo tests conducted in patient assessment. 2 Due to its ability to specifically destroy cancer cells utilizing heat radiation, PTT is currently attracting more and more attention in scientific circles.…”

Section: Phototherapy and Its Role In Cancer Biomodulationmentioning

confidence: 99%

Carbonaceous Nanomaterials for Phototherapy of Cancer

Gupta

Pawar

Vasdev

et al. 2023

Technol Cancer Res Treat

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Carbonaceous nanomaterials (CNMs) have drawn tremendous biomedical research interest because of their unique structural features. Recently, CNMs, namely carbon dots, fullerenes, graphene, etc, have been successful in establishing them as considerable nanotherapeutics for phototherapy applications due to their electrical, thermal, and surface properties. This review aims to crosstalk the current understanding of CNMs as multimodal compounds in photothermal and photodynamic therapies as an integrated approach to treating cancer. It also expounds on phototherapy’s biomechanics and illustrates its relation to cancer biomodulation. Critical considerations related to the structural properties, fabrication approaches, surface functionalization strategies, and biosafety profiles of CNMs have been explained. This article provides an overview of the most recent developments in the study of CNMs used in phototherapy, emphasizing their usage as nanocarriers. To conquer the current challenges of CNMs, we can raise the standard of cancer therapy for patients. The review will be of interest to the researchers working in the area of photothermal and photodynamic therapies and aiming to explore CNMs and their conjugates in cancer therapy.

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Photothermal therapy as emerging combinatorial therapeutic approach

Cited by 10 publications

References 139 publications

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Mechanical properties of polymer matrix/glass fiber composites containing metal/hybrid nanoparticles-an overview

Carbonaceous Nanomaterials for Phototherapy of Cancer

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