Photothermal Theragnosis Synergistic Therapy Based on Bimetal Sulphide Nanocrystals Rather Than Nanocomposites

Abstract

A new generation of photothermal theranostic agents is developed based on Cu3BiS3 nanocrystals. A computed tomography imaging response and photothermal effect, as well as near-infrared fluorescence emission, can be simultaneously achieved through Cu3BiS3 nanocrystals rather than frequently used nanocomposites. These results provide some insight into the synergistic effect from bimetal sulphide semiconductor compounds for photothermal theragnosis therapy.

FeSe2‐Decorated Bi2Se3 Nanosheets Fabricated via Cation Exchange for Chelator‐Free 64Cu‐Labeling and Multimodal Image‐Guided Photothermal‐Radiation Therapy

“…On the other hand, since Bismuth (Bi) processes larger X-ray absorption coefficient than that of other reported and extensively applied elements (Bi : 5.74, Au : 5.16, W : 4.44, and I : 1.94 cm −2 kg −1 at 100 keV) [19] , it is expected that FeSe 2 /Bi 2 Se 3 -PEG could also provide strong contrast under CT imaging. With increasing nanostructure concentrations, the CT signals of FeSe 2 /Bi 2 Se 3 -PEG solutions were enhanced (Figure 3E).…”

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

“…Compared to other conventional therapeutic techniques, PTT boasts many merits such as the simplicity, minimal invasiveness, low incidence of complications, as well as the high spatial and temporal precision of NIR light 8, 9, 10, 11. Various types of nanoagents have been explored to attain better PTT performance12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 and in the treatment, intravenous injection of the nanoagents (to mice, for example) is followed by high‐power NIR laser irradiation for ablation 25, 26, 27, 28, 29. Despite recent progress, clinical adoption of PTT still faces several hurdles.…”

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

“…To date, various shapes of bismuth sulfide NPs have been exploited, including spheres [16] and rods [17] for photothermal therapy (PTT) or CT contrast imaging in addition to ternary nanomaterials Cu 3 BiS 3 . [18] Meanwhile, bismuth sulfide NPs with a wide range of size from 5 to 300 nm have also been investigated for in vivo CT imaging. [19] …”