Photothermal nanozymes to self-augment combination cancer therapy by dual-glutathione depletion and hyperthermia/acidity-activated hydroxyl radical generation

Wang, Tzu‐Hao; Shen, Ming-Yen; Yeh, Nien-Tzu; Chen, Yu‐Hsin; Hsu, Tsai‐Ching; Chin, Hao-Yang; Wu, Yi-Ting; Tzang, Bor‐Show; Chiang, Wen‐Hsuan

doi:10.1016/j.jcis.2023.07.134

Cited by 7 publications

(2 citation statements)

References 70 publications

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“…Chiang et al synthesized a multifunctional nanozyme (Fe 3+ @PEG-CS/PDA) by coordinating Fe 3+ with polydopamine (PDA) nanoparticles, enabling the valence state transition of Fe 3+ mediated by GSH and facilitating the Michael reaction between GSH and quinone-rich PDA. 225 Consequently, these nanozymes effectively deplete GSH at elevated temperatures, thereby promoting PDT. Overall, these findings underscored the potential of photothermal-enhanced catalytic therapy for antitumor treatment.…”

Section: Chemodynamic Therapymentioning

confidence: 99%

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Fu,

Wei,

Wang

2024

ACS Nano

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Cancer, as one of the leading causes of death worldwide, drives the advancement of cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as promising therapeutic nanodrugs that provide a reference for cancer therapy. In this review, we present recent breakthrough nanozymes for cancer treatment. First, we comprehensively outline the preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal method, chemical reduction method, biomimetic mineralization method, and sol−gel method. Subsequently, we elucidate the catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like activities), oxidase (OXD)-like activities) and superoxide dismutase (SOD)-like activities) of transition-metal-based nanozymes along with their activity regulation strategies such as morphology control, size manipulation, modulation, composition adjustment and surface modification under environmental stimulation. Furthermore, we elaborate on the diverse applications of transition-metal-based nanozymes in anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), immunotherapy, and synergistic therapy. Finally, the challenges faced by transition-metal-based nanozymes are discussed alongside future research directions. The purpose of this review is to offer scientific guidance that will enhance the clinical applications of nanozymes based on transition metals.

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Section: Chemodynamic Therapymentioning

confidence: 99%

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Fu,

Wei,

Wang

2024

ACS Nano

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“…Moreover, the reductive GSH competes with DA for the substrate H 2 O 2 and reacts with quinone-rich PDA via a Michael addition reaction, thereby recovering the fluorescence signal and peroxidase-like activity of PH-DNFs. 21,22 Therefore, the proposed biosensor based on PH-DNFs was further used for GSH detection in a “signal-on” mode (Fig. S11, ESI†).…”

mentioning

confidence: 99%

Dual-mode optical biosensor based on multi-functional DNA structures for detecting bioactive small molecules

Guo,

Chen,

Wang

et al. 2024

Chem. Commun.

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Sun,

Zhang

et al. 2024

Adv Healthcare Materials

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Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species (ROS)‐mediated cancer therapies, exhibiting its potential as a sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions and hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals (•OH). Its notable advantages in cancer treatment have been demonstrated, including tumor specificity, autonomy from external triggers, and a favorable side‐effect profile. Recent advancements in nanomedicine have been devoted to enhancing CDT, promising a comprehensive optimization of CDT efficacy. This review systematically elucidates cutting‐edge achievements in chemodynamic nanotherapeutics, exploring strategies for enhanced Fenton or Fenton‐like reactions, improved tumor microenvironment modulation, and precise regulation in energy metabolism. Moreover, a detailed analysis of diverse CDT‐mediated combination therapies is provided. Finally, the review concludes with a comprehensive discussion of the prospects and intrinsic challenges to the application of chemodynamic nanotherapeutics in the domain of cancer treatment.This article is protected by copyright. All rights reserved

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Photothermal nanozymes to self-augment combination cancer therapy by dual-glutathione depletion and hyperthermia/acidity-activated hydroxyl radical generation

Cited by 7 publications

References 70 publications

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Dual-mode optical biosensor based on multi-functional DNA structures for detecting bioactive small molecules

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

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