Photothermal effects on protein adsorption dynamics of PEGylated gold nanorods

Polo, Ester; Araban, Vida; Pelaz, Beatriz; Alvarez, Aitor; Taboada, Pablo; Mahmoudi, Morteza; Pino, Pablo del

doi:10.1016/j.apmt.2019.04.013

Cited by 24 publications

(19 citation statements)

References 40 publications

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“…11 The use of PEO for modifying the surface properties of gold substrates to prevent nonspecific adsorption of proteins and to improve the colloidal stability and biocompatibility of gold nanoparticles is well recognized. [12][13][14] Linear PEO and PEO architectures such as star-shaped, grafted, branched, hyperbranched, and dendrimer-like structures have been explored for a diversity of biomedical applications including drug delivery, wound healing, and tissue and bone engineering. 11,15,16 However, only a limited amount of work has focused on the utility of macrocyclic PEO structures for biomedical applications, [17][18][19] none of them on modifying gold substrates.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of macrocyclic poly(ethylene oxide)s containing a protected thiol group: a strategy for decorating gold surfaces with ring polymers

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Synthesis of macrocyclic poly(ethylene oxide)s containing a protected thiol group: a strategy for decorating gold surfaces with ring polymers

et al. 2019

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“…To match the wavelength of our NIR optical system (808 nm) and to maximize photothermal conversion, low‐scattering ultrathin GNRs with aspect ratio of 3.8 (length L GNR = 41.7 ± 5.2 nm and width W GNR = 11.1 ± 1.8 nm, Figure S2, Supporting Information) were synthesized in aqueous solution at ≈26 °C, in the presence of the cationic surfactant cetyltrimethylammonium bromide (CTAB), using the method described by Sau and Murphy 27. The GNR's CTAB coating was exchanged by thiolated PEG polymers (HS‐PEG‐NH 2 ) using a two‐step ligand exchange process to yield positively charged PEGylated GNRs (Figure S3, Supporting Information) 28…”

Section: Resultsmentioning

confidence: 99%

Plasmonic Cell‐Derived Nanocomposites for Light‐Controlled Cargo Release inside Living Cells

et al. 2020

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Translating the potential of thermoplasmonics to cell‐derived nanomaterials offers exciting opportunities to fabricate beyond state‐of‐art artificial biomimetic nanocomposites that upon illumination perform active tasks such as delivery of cargo in complex, dynamic media such as the cytosol of cells. Cell‐derived nanoparticles have shown stunning potential to implement cell‐specific functions, such as long blood circulation or targeting capabilities, into advanced drug delivery nanosystems. The biomimicry nanotechnology has now advanced to offer new and exciting opportunities to improve the commonly poor in vivo performance of most current nanomedicines, including evading the immune system and targeting specific tissues such as tumors, the latest remaining among the most wanted breakthroughs in nanomedicine. However, the use of cell‐derived nanocomposites as stimulus‐controlled drug delivery agents remains virtually unexplored. This study reports the fabrication of a plasmonic cell‐derived nanocomposite by integrating near‐infrared active gold nanorods in its structure. As a proof of concept, the plasmonic nanomembranes are loaded with cell non‐permeant antibodies, which upon near‐infrared stimulation can be released from the plasmonic nanomembranes into the cytosol of living cells, without impairing cell viability or the antibodies' function. These results set the stage for the development of photoactive cell‐derived nanocarriers, which in addition to cell‐specific functions promise straightforward access to spatiotemporal‐controlled intracellular delivery of antibodies.

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“…For example, in a recent study, gold nanorods were covered with 5 kDa PEG chains carrying a -COOH terminal, -NH 2 terminal, or equal combination of PEGs carrying both terminal groups (Figure 3). The overall charges for these systems were negative, positive, or neutral (respectively), leading to nanorods with different binding affinities towards Bovine Serum Albumin (BSA), which exhibited the following trend: positively charged PEGylated-nanorods > negatively charged PEGylated-nanorods > neutral charged PEGylated-nanorods [41]. Likewise, a similar effect was observed when CdSe quantum dots (QDs) were coated with 0.6-1 kDa PEG chains containing -NH 2 , -COOH, or -OCH 3 terminal groups, and their interaction with BSA protein was studied using agarose gel electrophoresis [42].…”

Section: Pegylated Coatingsmentioning

confidence: 99%

“…Nanorods covered with 5 kDa PEG chains carrying a -COOH terminal, -NH 2 terminal, or an equal combination of PEGs carrying both terminal groups show different binding affinities towards Bovine Serum Albumin (BSA). Reprinted with permission from reference[41]. Copyright (2019) Elsevier.…”

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confidence: 99%

Recent Developments in the Design of Non-Biofouling Coatings for Nanoparticles and Surfaces

Sanchez‐Cano

Carril

2020

IJMS

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Biofouling is a major issue in the field of nanomedicine and consists of the spontaneous and unwanted adsorption of biomolecules on engineered surfaces. In a biological context and referring to nanoparticles (NPs) acting as nanomedicines, the adsorption of biomolecules found in blood (mostly proteins) is known as protein corona. On the one hand, the protein corona, as it covers the NPs’ surface, can be considered the biological identity of engineered NPs, because the corona is what cells will “see” instead of the underlying NPs. As such, the protein corona will influence the fate, integrity, and performance of NPs in vivo. On the other hand, the physicochemical properties of the engineered NPs, such as their size, shape, charge, or hydrophobicity, will influence the identity of the proteins attracted to their surface. In this context, the design of coatings for NPs and surfaces that avoid biofouling is an active field of research. The gold standard in the field is the use of polyethylene glycol (PEG) molecules, although zwitterions have also proved to be efficient in preventing protein adhesion and fluorinated molecules are emerging as coatings with interesting properties. Hence, in this review, we will focus on recent examples of anti-biofouling coatings in three main areas, that is, PEGylated, zwitterionic, and fluorinated coatings.

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Photothermal effects on protein adsorption dynamics of PEGylated gold nanorods

Cited by 24 publications

References 40 publications

Synthesis of macrocyclic poly(ethylene oxide)s containing a protected thiol group: a strategy for decorating gold surfaces with ring polymers

Synthesis of macrocyclic poly(ethylene oxide)s containing a protected thiol group: a strategy for decorating gold surfaces with ring polymers

Plasmonic Cell‐Derived Nanocomposites for Light‐Controlled Cargo Release inside Living Cells

Recent Developments in the Design of Non-Biofouling Coatings for Nanoparticles and Surfaces

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