Photothermal conversion of SiO<sub>2</sub>@Au nanoparticles mediated by surface morphology of gold cluster layer

Yang, Lulu; Yan, Zhibin; Lu, Yang; Yang, Jian; Jin, Mingliang; Xing, Xiaobo; Zhou, Guofu; Shui, Lingling

doi:10.1039/d0ra06278b

Cited by 17 publications

(14 citation statements)

References 57 publications

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“…A similar relationship between energy per pulse and OA signal intensity at high fluence levels was shown to be produced for gold-wrapped carbon nanotubes and carbon nanotubes. , It was also previously reported that the photodamage threshold for a single Au sphere of 20–50 nm lies in the range 33–80 mJ/cm 2 for 532 nm excitation with a nanosecond pulsed laser . However, the behavior of gold clusters is more complicated due to high plasmonic coupling between nanoparticles, which could lead to an increase in the light-to-heat conversion and a consequent shift of the energy threshold to a lower range. − No significant nonlinear effects as a function of fluence were observed in OA signals collected with the OAT system for fluence levels used in vivo (Figure S3d). Note that such signals correspond to a suspension of microparticles in PBS that may slightly move during data acquisition.…”

Section: Resultssupporting

confidence: 72%

Rapid Volumetric Optoacoustic Tracking of Individual Microparticles In Vivo Enabled by a NIR-Absorbing Gold–Carbon Shell

Nozdriukhin

Kalva

et al. 2021

ACS Appl. Mater. Interfaces

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Rapid volumetric in vivo visualization of circulating microparticles can facilitate new biomedical applications, such as blood flow characterization or targeted drug delivery. However, existing imaging modalities generally lack the sensitivity to detect the weak signals generated by individual micrometer-sized particles distributed across millimeter-to centimeter-scale depths in living mammalian tissues. Also, the temporal resolution is typically insufficient to track the particles in an entire three-dimensional region. Herein, we introduce a new type of monodisperse (4 μm) silica-core microparticle coated with a shell formed by a multilayered structure of carbon nanotubes (CNT) and gold nanoparticles (AuNP) to provide strong optoacoustic (OA) absorption-based contrast. We capitalize on the unique advantages of a state-of-the-art high-frame-rate OA tomography system to visualize and track the motion of these core−shell particles individually and volumetrically as they flow throughout the mouse brain vasculature. The feasibility of localizing individual solid particles smaller than red blood cells opens new opportunities for mapping the blood flow velocity, enhancing the resolution and visibility of OA images, and developing new biosensing assays.

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Section: Resultssupporting

confidence: 72%

Rapid Volumetric Optoacoustic Tracking of Individual Microparticles In Vivo Enabled by a NIR-Absorbing Gold–Carbon Shell

Nozdriukhin

Kalva

et al. 2021

ACS Appl. Mater. Interfaces

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“…Thus, we obtained the core@shell structure of PBA@SiO 2 (Figures S3 and S4, Supporting Information). In order to introduce the function of glucose consumption [ 24 ]

(glucose + {normalO}_{2} \overset{AuNPs}{\to} gluconic acid + {normalH}_{2} {normalO}_{2})

and photothermal conversion [ 25,26 ] from gold nanoparticles, the exchange of the ligand with 3‐aminopropyltriethoxysilane and a redox reaction with HAuCl 4 further resulted in the formation of PBA@SiO 2 ‐Au NPs. These PBA@SiO 2 ‐Au NPs showed a distinctive hierarchical hybrid structure and had a diameter of 142.4 ± 4.6 nm.…”

Section: Resultsmentioning

confidence: 99%

Biocompatible Inorganic Nanoagent for Efficient Synergistic Tumor Treatment with Augmented Antitumor Immunity

Lü

Zheng

et al. 2022

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.202200897.Synergistic therapy for malignant tumors has been developed in the past. However, several disadvantages that are associated with the applied inorganic nanoagents cannot be avoided, including intrinsic systemic toxicity, immunosuppression, and low therapeutic efficiency. Herein, a biocompatible, multifunctional, inorganic nanoagent that simultaneously integrates chemodynamic, starvation, and photothermal therapies is developed. This nanoagent effectively converts endogenous H 2 O 2 into highly toxic hydroxyl radicals via the Fenton reaction. Self-reinforced cancer therapy is achieved via the scavenging of intracellular glutathione and glucose. The encapsulation of nanoagent by erythrocytes drastically reduces its immune recognition by macrophages. Thus, an augmented anti-tumor immune response is realized. Moreover, in contrast to traditional inorganic chemodynamic nanomaterials, the nanoagent has outstanding photothermal efficiency. Therefore, the present system exhibits an effective tumor therapeutic outcome. This work may facilitate a new pathway for the development of highly efficacious synergetic therapies.

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“…We focused on light irradiation combination with metal nanoparticles since no mechanism of resistance has yet been identified. The photothermal conversion mediated by metal nanoparticles ( Kim et al, 2019 ; Yang et al, 2020 ) triggers a local surge in temperature ( Supplementary Table 4 ) that impacts bacteria cells’ viability and the stability of the extracellular matrix, decreasing its thickness ( Jo and Kim, 2013 ; Wang et al, 2019 ; Beckwith et al, 2020 ; Pinel et al, 2021 ). Previous studies have shown that the structure and the integrity of bacterial biofilms could be disrupted at higher temperatures ( Ibelli et al, 2018 ), thus decreasing the barrier limiting antimicrobial diffusion to different layers of the biofilm.…”

Section: Resultsmentioning

confidence: 99%

Light Triggered Enhancement of Antibiotic Efficacy in Biofilm Elimination Mediated by Gold-Silver Alloy Nanoparticles

et al. 2022

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Bacterial biofilm is a tri-dimensional complex community of cells at different metabolic stages involved in a matrix of self-produced extracellular polymeric substances. Biofilm formation is part of a defense mechanism that allows the bacteria to survive in hostile environments, such as increasing resistance or tolerance to antimicrobial agents, causing persistent infections hard to treat and impair disease eradication. One such example is bovine mastitis associated with Streptococcus dysgalactiae subsp. dysgalactiae (SDSD), whose worldwide health and economic impact is on the surge. As such, non-conventional nanobased approaches have been proposed as an alternative to tackle biofilm formation and to which pathogenic bacteria fail to adapt. Among these, metallic nanoparticles have gained significant attention, particularly gold and silver nanoparticles, due to their ease of synthesis and impact against microorganism growth. This study provides a proof-of-concept investigation into the use of gold-silver alloy nanoparticles (AuAgNPs) toward eradication of bacterial biofilms. Upon visible light irradiation of AuAgNPs there was considerable disturbance of the biofilms’ matrix. The hindering of structural integrity of the biofilm matrix resulted in an increased permeability for entry of antibiotics, which then cause the eradication of biofilm and inhibit subsequent biofilm formation. Additionally, our results that AuAgNPs inhibited the formation of SDSD biofilms via distinct stress pathways that lead to the downregulation of two genes critical for biofilm production, namely, brpA-like encoding biofilm regulatory protein and fbpA fibronectin-binding protein A. This study provides useful information to assist the development of nanoparticle-based strategies for the active treatment of biofilm-related infections triggered by photoirradiation in the visible.

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Photothermal conversion of SiO₂@Au nanoparticles mediated by surface morphology of gold cluster layer

Abstract: We manipulate the surface morphology of gold clusters on SiO2@Au nanoparticle and found that macroscopic photothermal conversions of different nanoparticle dispersions are significantly affected by nanoscale differences of gold cluster morphologies.

Cited by 17 publications

References 57 publications

Rapid Volumetric Optoacoustic Tracking of Individual Microparticles In Vivo Enabled by a NIR-Absorbing Gold–Carbon Shell

Rapid Volumetric Optoacoustic Tracking of Individual Microparticles In Vivo Enabled by a NIR-Absorbing Gold–Carbon Shell

Biocompatible Inorganic Nanoagent for Efficient Synergistic Tumor Treatment with Augmented Antitumor Immunity

Light Triggered Enhancement of Antibiotic Efficacy in Biofilm Elimination Mediated by Gold-Silver Alloy Nanoparticles

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Photothermal conversion of SiO2@Au nanoparticles mediated by surface morphology of gold cluster layer

Abstract: We manipulate the surface morphology of gold clusters on SiO2@Au nanoparticle and found that macroscopic photothermal conversions of different nanoparticle dispersions are significantly affected by nanoscale differences of gold cluster morphologies.

Cited by 17 publications

References 57 publications

Rapid Volumetric Optoacoustic Tracking of Individual Microparticles In Vivo Enabled by a NIR-Absorbing Gold–Carbon Shell

Rapid Volumetric Optoacoustic Tracking of Individual Microparticles In Vivo Enabled by a NIR-Absorbing Gold–Carbon Shell

Biocompatible Inorganic Nanoagent for Efficient Synergistic Tumor Treatment with Augmented Antitumor Immunity

Light Triggered Enhancement of Antibiotic Efficacy in Biofilm Elimination Mediated by Gold-Silver Alloy Nanoparticles

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Photothermal conversion of SiO₂@Au nanoparticles mediated by surface morphology of gold cluster layer