Photothermal ablation of pancreatic cancer cells with hybrid iron-oxide core gold-shell nanoparticles

Guo, Yang; Zhang, Zhuoli; Kim, Dong‐Hyun; Li, Weiguo; Nicolai, J.; Procissi, Daniele; Yi, Huan; Han, Guoliang; Omary, Reed A.; Larson, Andrew C.

doi:10.2147/ijn.s47585

Cited by 62 publications

(40 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The HNP preparation and characterisation has been reported previously [21,22] along with their ability to undergo triggered heating upon laser irradiation in agar phantoms [17,34], in vitro and in situ in tumour bearing mouse cadavers [35,36]. Drug attachment was carried out at three drug:HNP weight ratios (5:1, 2.5:1 and 1:1 based on Fe weight of HNP) for all four bisnaphthalamide based drugs.…”

Section: Hnp-drug Conjugation and Characterisationmentioning

confidence: 99%

Thermally triggered theranostics for pancreatic cancer therapy

et al. 2017

View full text Add to dashboard Cite

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation reverses drug binding. This study exploits the reversible binding of novel polyamine based drugs in order to provide specific and effective method for pancreatic cancer treatment. Here we used novel bisnaphthalamido (BNIP) based drug series. Our hybrid nanoparticles (50 nm) were capable of drug loading onto their surface (3:1:0.25, Drug:Fe:Au). By exploiting the surface-to-drug electrostatic interaction of a range of BNIP agents, heat triggered drug release was achieved.12-fold reduction in IC 50 after 24 h in vitro and 5-fold reduction of tumour retardation in vivo compared with free drug in pancreatic models after treatment with the HNP-formulation and laser irradiation. This heat activated system could provide a key platform for future therapy strategies.

show abstract

Section: Hnp-drug Conjugation and Characterisationmentioning

confidence: 99%

Thermally triggered theranostics for pancreatic cancer therapy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The specific nanostructure of the gold nanoshells could also allow nearinfrared light to be absorbed and converted into heat whereby cancer cells are exposed to slightly higher temperatures than usual to destroy them [21]. Some studies have demonstrated the use of iron oxide gold-shell nanoparticles that are MRI-visible photothermal sensitizers during laser irradiation of pancreatic cancer cells [24]. Exposure to iron oxide gold-shell nanoparticles followed by laser irradiation led to significant improvement in the management of pancreatic cancer cell [24].…”

Section: Destruction From Inside the Cellmentioning

confidence: 99%

“…Some studies have demonstrated the use of iron oxide gold-shell nanoparticles that are MRI-visible photothermal sensitizers during laser irradiation of pancreatic cancer cells [24]. Exposure to iron oxide gold-shell nanoparticles followed by laser irradiation led to significant improvement in the management of pancreatic cancer cell [24]. There are some major disadvantages for nanoshell therapy such as drug toxicity and tumor resistance.…”

Section: Destruction From Inside the Cellmentioning

confidence: 99%

Nanomedicine - the Future of Cancer Treatment: A Review

Sebastian¹

2017

JCPCR

View full text Add to dashboard Cite

Conventional cancer therapies are limited to surgery, radiation, and chemotherapy. Conventional treatments come with significant adverse effects. Modern cancer treatments focus on precise drug delivery to the cancer tissues and minimize adverse effects on healthy cells. Researchers have been working on an improved technique for delivering chemotherapeutic agents precisely at the molecular level in the tumor tissue. It has led to the use of nanotechnology in cancer treatment. Nanotechnology is the science and engineering of controlling matter, at the molecular scale, to create devices with novel chemical, physical and biological properties. Nanoscale objects are used themselves or as part of larger devices containing multiple nanoscale objects. Almost every field of Biosciences uses nanotechnology and all of which have an impact on biomedicine. It has the potential to change the current methods to diagnose and treat cancer. There has been real progress in translating nano-based cancer therapies and diagnostics into the clinic, and much more are in development. Nanoparticles are mainly used as nanocarriers to deliver the cytotoxic drugs to the tumor tissue. Use of nanoparticles is based on different concepts of pharmacology. Nanomedicine also is utilized to deliver multiple drugs at the cancer site at the same time for a better cytotoxic effect. CytImmune Sciences is a developing field of nanomedicine for targeted chemotherapy method. They selectively deliver the drug at the cancer site because of the increased permeability of the blood vessels at the tumor site. This article reviews various nanomedicine-based cancer therapeutics.

show abstract

“…This oxygen is highly toxic and leads to cell death via apoptosis or necrosis [1]. Photofrin®, also known as porfimer sodium is an FDA approved photosensitizing agent, used in the management of non-small cell lung cancer and esophageal cancer [2]. Porfimer sodium has proved effective in relieving symptoms of esophageal cancer when the mass obstructs the esophagus or when it is untreatable with laser alone.…”

Section: Photodynamic Therapymentioning

confidence: 99%

“…Phototherapy could enhance Heat Shock Proteins (HSP). HSP expression in the tumor cells, in particular on the cell surface of apoptotic cells, which could be recognized by APCs through toll-like receptor (TLRs), followed by cytokine release via Myd88 and NF-kB signaling pathways [2]. In particular, phototherapy, as a promising cancer treatment strategy that uses a local, selective photothermal or photochemical interaction on target tumor to release tumor antigens, creates an antigen source that acts as an in situ cancer vaccine.…”

Section: Photothermal Therapymentioning

confidence: 99%

Phototherapy in Cancer Prevention and Treatment

L¹

2017

JCPCR

View full text Add to dashboard Cite

Phototherapy is a safe, and secure way to destroy cancer cells when light waves of a particular wavelength used with appropriate activating agents. It is usually limited by its nature to illnesses that are skin-deep. Researchers developed a phototherapy method that brings light directly to tumor cells, no matter how deep they are. Phototherapy also has demonstrated promising results in diagnosing and treating various types of cancers. The combination of nanomedical agents and phototherapy modalities has shown better results than individual therapy. Further research should be encouraged to formulate an effective combination of activating agents and phototherapy for the best outcome, to minimize adverse effects and to prevent injury to healthy tissues. This article reviews different types phototherapy methods to treat cancer.

show abstract

Photothermal ablation of pancreatic cancer cells with hybrid iron-oxide core gold-shell nanoparticles

Cited by 62 publications

References 40 publications

Thermally triggered theranostics for pancreatic cancer therapy

Thermally triggered theranostics for pancreatic cancer therapy

Nanomedicine - the Future of Cancer Treatment: A Review

Phototherapy in Cancer Prevention and Treatment

Contact Info

Product

Resources

About