Phototherapy — Traditional and Nontraditional

Mj, Maisels

doi:10.1038/sj.jp.7210642

Cited by 92 publications

(80 citation statements)

References 21 publications

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“…9 Phototherapy is considered one of the safest treatment methods for newborns. 1,3 However, the biologic effects of blue lights on cells in vitro have long been a subject for concern. 20 Blue light generated by fluorescent lamps has been reported to induce singlestrand breaks in the DNA of cells in culture in the absence of bilirubin.…”

Section: Discussionmentioning

confidence: 99%

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A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

et al. 2003

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OBJECTIVE:To determine the efficacy of blue versus blue-green phototherapy using new light sources with narrow luminous spectra. The devices made of highintensity gallium nitride light-emitting diodes (LEDs) were also compared to conventional halogen-quartz bulbs phototherapy. DESIGN:Prospective open randomized study. PARTICIPANTS:A total of 114 jaundiced, but otherwise healthy term infants who met the entry criteria for phototherapy set by the American Academy of Pediatrics' Practice Parameter. MAIN OUTCOME MEASURES:The duration of phototherapy and the rate of decrease in total serum bilirubin (TSB). RESULTS:The mean TSB concentrations at initiation and termination of treatment, as well as the duration of phototherapy and the rate of decrease in TSB, were not statistically different in newborns receiving blue LED, blue-green LED or conventional phototherapy. The average rate of decrease in TSB (slope), after adjustment by a linear regression analysis for confounding factors, was À3.61 mmol/hour (95% confidence limits À5.47, À1.75) in the 25 newborns receiving blue LED phototherapy compared with À2.57 mmol/hour (À4.32, À0.82) in the 22 newborns treated with bluegreen LED phototherapy and À3.42 mmol/hour (À5.02, À1.81) in the 57 newborns who received conventional phototherapy. CONCLUSIONS:When using low light irradiance, there was no statistically significant difference in the effectiveness of phototherapy using blue-green LEDs, blue LEDs or conventional halogen-quartz bulbs.

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Section: Discussionmentioning

confidence: 99%

“…2 When broad-spectrum white light is used for treatment, only a fraction of the light is acting on the bilirubin. 3 Moreover, bilirubin does not absorb the different colors of light equally. Blue light at about 450 nm is absorbed most readily, while green light is less well absorbed.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

et al. 2003

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“…Certainly, effective phototherapy has dramatically decreased the need for exchange transfusion in preterm infants, so that this procedure has become increasingly rare in the NICU. 23,25,35,36 In the Neonatal Research Network Study, 25 only 5 of 1974 (0.25%) ELBW infants received an exchange transfusion.…”

Section: Phototherapymentioning

confidence: 99%

An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation

et al. 2012

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We provide an approach to the use of phototherapy and exchange transfusion in the management of hyperbilirubinemia in preterm infants of <35 weeks of gestation. Because there are limited data for evidence-based recommendations, these recommendations are, of necessity, consensusbased. The recommended treatment levels are based on operational thresholds for bilirubin levels and represent those levels beyond which it is assumed that treatment will likely do more good than harm. Long-term follow-up of a large population will be needed to evaluate whether or not these recommendations should be modified.

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“…And also, interestingly, there no any case with hyperthermia in conventional phototherapy group. But, as stated in the article, best to our knowledge the LED based devices produce minimal heat while generating high irradiance [2]. We think these hyperthermia rates are very high based upon our knowledge and daily clinical practice.…”

mentioning

confidence: 94%

Body Temperature Changes of Newborns Under Fluorescent Versus LED Phototherapy: Correspondence

2013

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Aydemir et al. [1] that compared the body temperature (BT) changes of newborns under conventional phototherapy with fluorescent lamps and light emitting diodes (LED) phototherapy at different irradiances. The authors suggest that LED phototherapy of ≥ 60 μW/cm 2 /nm intensity significantly increases BT in hyperbilirubinemic newborns. Furthermore, they reported that all patients receiving LED phototherapy at high intensity had at least one BT measurement of ≥ 37.5°C and 77 % had BT of ≥ 38°C. And also, interestingly, there no any case with hyperthermia in conventional phototherapy group. But, as stated in the article, best to our knowledge the LED based devices produce minimal heat while generating high irradiance [2]. We think these hyperthermia rates are very high based upon our knowledge and daily clinical practice.In addition, because LED based devices do not produce much heat, hypothermia may be a problem for small and sick newborns, and also in environments without temperature control, for example in an open crib. Therefore, in such situations, closer temperature monitoring, and also an external heat source may be required [3].Our conclusion is that more studies are required to confirm that LED phototherapy causes more side effect of hyperthermia than conventional phototherapy in newborns.Contribution Dr. Mustafa Aydin will act as guarantor for this paper. Conflict of Interest None.Role of Funding Source None.

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Phototherapy — Traditional and Nontraditional

Cited by 92 publications

References 21 publications

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation

Body Temperature Changes of Newborns Under Fluorescent Versus LED Phototherapy: Correspondence

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