Phototherapeutic keratectomy for Reis Bucklers' corneal dystrophy

Rogers, Christopher; Cohen, Peter; Lawless, Michael

doi:10.1111/j.1442-9071.1993.tb00963.x

Cited by 24 publications

(12 citation statements)

References 12 publications

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“…The flap cut, the flap lift, and the subsequent biomechanical and postoperative healing responses of the cornea have a small role in inducing HOAs in the eye after LASIK. [10][11][12][13][14][15][16] Another potential source of HOA induction after LASIK is dynamic eye movements that occur during the ablation. An additional mechanism that could be responsible for the increases in spherical aberration observed after LASIK is the efficiency of a laser pulse when striking different areas of the cornea.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Several mechanisms that could induce these aberrations are currently being investigated. [10][11][12][13][14][15][16][17][18][19] One source of induced postoperative aberrations could be a static offset of a wavefront-guided ablation due to shifts in pupil center location from when aberrations are measured preoperatively over a dilated pupil to when they are surgically corrected over an undilated pupil. It is important to understand the types and magnitudes of aberrations induced by decentered ablations to deliver an optimal customized correction of HOAs.…”

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confidence: 99%

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Aberrations induced in wavefront-guided laser refractive surgery due to shifts between natural and dilated pupil center locations

Porter

Yoon²,

Lozano³

et al. 2006

Journal of Cataract and Refractive Surgery

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Measuring aberrations over a Neo-Synephrine-dilated pupil and treating them over an undilated pupil typically resulted in a shift of the wavefront-guided ablation in the superotemporal direction and an induction of higher-order aberrations. Methods referencing the aberration measurement and treatment with respect to a fixed feature on the eye will reduce the potential for inducing aberrations due to shifts in pupil center.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Aberrations induced in wavefront-guided laser refractive surgery due to shifts between natural and dilated pupil center locations

Porter

Yoon²,

Lozano³

et al. 2006

Journal of Cataract and Refractive Surgery

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“…These TGFBI‐linked CDs are characterized by bilateral corneal deposits that usually appear between the first and fourth decade of life, progress over time and could lead to loss of vision by opacification of the central cornea during the third to sixth decades. Phototherapeutic keratectomy or corneal transplantation is necessary in severe cases (Ridgway & Moller, ; Rogers, Cohen, & Lawless, ). The deposits in GCD1 and RBCD seem identical, but in GCD1 they are localized deeper in subepithelial and stromal layers, whereas in RBCD they are in the epithelial and Bowman layers and occur earlier in life.…”

Section: Tgfbi Expression Role and Pathology In The Eye Of Humans Amentioning

confidence: 99%

Mutation update:TGFBIpathogenic and likely pathogenic variants in corneal dystrophies

et al. 2019

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Human transforming growth factor β‐induced (TGFBI), is a gene responsible for various corneal dystrophies. TGFBI produces a protein called TGFBI, which is involved in cell adhesion and serves as a recognition sequence for integrins. An alteration in cell surface interactions could be the underlying cause for the progressive accumulation of extracellular deposits in different layers of the cornea with the resulting changes of refractive index and transparency. To this date, 69 different pathogenic or likely pathogenic variants in TGFBI have been identified in a heterozygous or homozygous state in various corneal dystrophies, including a novel variant reported here. All disease‐associated variants were inherited as autosomal‐dominant traits but one; this latter was inherited as an autosomal recessive trait. Most corneal dystrophy‐associated variants are located at amino acids Arg124 and Arg555. To keep the list of corneal dystrophy‐associated variant current, we generated a locus‐specific database for TGFBI (http://databases.lovd.nl/shared/variants/TGFBI) containing all pathogenic and likely pathogenic variants reported so far. Non‐disease‐associated variants are described in specific databases, like gnomAD and ExAC but are not listed here. This article presents the most recent up‐to‐date list of disease‐associated variants.

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“…Roberts and other authors have noted an increased flattening and hyperopic shifts in studies on PTK and myopic PRK and LASIK. [13][14][15][16][17] This effect can be attributed to a severing and retraction of the collagen lamellae. Corneal topography reveals this thickening and steepening of the midperiphery with the "red ring," which is associated with positive spherical aberration.…”

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confidence: 99%

Separate effects of the microkeratome incision and laser ablation on the eye’s wave aberration

Porter¹,

MacRae

Yoon

et al. 2003

American Journal of Ophthalmology

134

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• PURPOSE: To study the optical changes induced by the microkeratome cut, the subsequent laser ablation, and the biomechanical healing response of the cornea in normal laser in situ keratomileusis (LASIK) eyes.• DESIGN: Prospective randomized clinical trial.• METHODS: A Hansatome microkeratome was used to cut a corneal flap in one eye (study eye) of 17 normal myopic patients and a subsequent laser ablation was performed 2 months after this initial microkeratome incision. Control eyes received conventional LASIK treatments at the latter time point. The wave aberration of both the study and contralateral control eyes were measured over a 6-mm pupil with a Shack-Hartmann wavefront sensor for all preoperative, postflap cut, and postablation visits.• RESULTS: The eye's higher order aberrations had a small, but significant increase (P ‫؍‬ .03) of approximately 30% 2 months after cutting a flap. No systematic changes were observed in nearly all Zernike coefficients from their preoperative levels at 2 months postflap cut. A significant difference between the study and control eyes was observed for one trefoil mode, Z 3 3 (P ‫؍‬ .04).• CONCLUSIONS: There was a wide variation in the response of individual Zernike modes across patients after cutting a flap. The majority of spherical aberration induced by the LASIK procedure seems to be due to the laser ablation and not the microkeratome cut. In addition, the total and higher order root mean square of wavefront errors were nearly identical for both the study and control eyes 3-months after the laser ablation, indicating that a procedure in which the incision and the ablation are separated in time to better control aberrations does not compromise the outcome of a conventional LASIK treatment. ( have been encouraging, further refinements of wavefront-guided laser in situ keratomileusis (LASIK) procedures are needed to obtain an aberration-free ablative correction. 1-4 It has been well established that conventional photorefractive keratectomy (PRK) and LASIK procedures induce higher order aberrations, including increased amounts of spherical aberration, despite their accurate correction of spherocylindrical errors. [5][6][7][8][9][10] To date, little evidence has been presented to determine the origins of these induced higher order aberrations. Consequently, not much is known about the importance or relative contribution of the two separate effects of creating a microkeratome flap and performing a subsequent laser ablation on the overall optical quality of an eye receiving a LASIK treatment. Developing a firm understanding of the aberrations induced by these two processes is crucial for achieving an optimal, customized correction of the eye's higher order aberrations with laser refractive surgery.Studies have been conducted to investigate structural changes in corneal shape due to the laser ablation in refractive surgery procedures. Howland and coworkers 11 found that changes made in the midperipheral and peripheral cornea could create biomechanical changes in the central corn...

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Phototherapeutic keratectomy for Reis Bucklers' corneal dystrophy

Cited by 24 publications

References 12 publications

Aberrations induced in wavefront-guided laser refractive surgery due to shifts between natural and dilated pupil center locations

Aberrations induced in wavefront-guided laser refractive surgery due to shifts between natural and dilated pupil center locations

Mutation update:TGFBIpathogenic and likely pathogenic variants in corneal dystrophies

Separate effects of the microkeratome incision and laser ablation on the eye’s wave aberration

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