Phototherapeutic keratectomy for BIGH3-linked corneal dystrophy recurring after penetrating keratoplasty

Ellies, Pierre; Bejjani, R.A.; Bourges, Jean‐Louis; Boëlle, Pierre‐Yves; Renard, G; Dighiero, P.

doi:10.1016/s0161-6420(03)00229-x

Cited by 32 publications

(22 citation statements)

References 34 publications

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“…Excimer laser phototherapeutic keratectomy was successfully performed on the proband with a promising early postoperative result, although repeat procedures are likely to be required. 20 TEM of a specimen taken during surgery showed rod-shaped deposits in Bowman's layer, which is consistent with a diagnosis of RBCD. This novel association of the RBCD phenotype with the R555Q genotype challenges current knowledge about phenotype specificity.…”

Section: Discussionsupporting

confidence: 75%

Arg555Gln Mutation of TGFBI Gene in Geographical-Type Reis—Bücklers Corneal Dystrophy in a Chinese Family

et al. 2012

J Int Med Res

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Section: Discussionsupporting

confidence: 75%

Arg555Gln Mutation of TGFBI Gene in Geographical-Type Reis—Bücklers Corneal Dystrophy in a Chinese Family

et al. 2012

J Int Med Res

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“…Of note, phototherapeutic keratectomy of a corneal graft has also been shown to be a safe and effective alternative to repeat grafting. 25 However, in clinically similar disorders such as atypical cases of GCD type I, penetrating keratoplasty may be indicated at an earlier stage of disease because the recurrence rate is lower and because phototherapeutic keratectomy may not satisfactorily improve vision if there are deeper stromal opacities.…”

Section: Results Clinical Findings Probandmentioning

confidence: 99%

Two Cases of Reis-Bücklers Corneal Dystrophy (Granular Corneal Dystrophy Type III) Caused by Spontaneous Mutations in the TGFBI Gene

Tanhehco¹,

Eifrig²,

Schwab³

et al. 2006

Arch Ophthalmol

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“…[ 8 9 ] LKP or PKP were performed before the availability of the excimer laser. [ 10 11 ] Since the recurrences are superficial,[ 12 13 ] a retreatment with an excimer laser is possible avoiding the complications of PKP. [ 11 14 15 ] The aim of this study is to assess the clinical and visual outcomes after performing PTK in eyes that had prior grafts.…”

mentioning

confidence: 99%

Phototherapeutic keratectomy for recurrent granular dystrophy in postpenetrating keratoplasty eyes

Rathi

Taneja

Murthy

et al. 2016

Indian J Ophthalmol

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Purpose:The purpose is to assess the clinical and visual outcome after phototherapeutic keratectomy (PTK) procedure in eyes with prior penetrating keratoplasty (PKP) for granular corneal dystrophy (GCD) and the time of performance of repeat PTK for recurrence.Methods:PTK was performed for visually significant recurrence: A reduction in best-corrected visual acuity (BCVA) by >2 lines over BCVA before recurrence was considered as visually significant recurrence. Three eyes had amniotic membrane patch performed with PTK. The main outcome measures were a recurrence of GCD, clinical course, and visual outcome. Intervals between repeat PTK procedures were noted.Results:Six patients (n = 10 eyes; males: 4, mean age 39 ± 13.97 years) underwent PTK. The mean pachymetry before first PTK was 527.1 ± 34 microns. The mean duration between PKP and first PTK was 85.1 months (range: 37–108 months). Two and three PTK procedures were done for seven and five eyes, respectively. Mean duration between first and second and second and third PTK was 62.12 ± 34.41 and 42.8 ± 13.54 months respectively. The average cut depth was 43.66 ± 19.57, 75 ± 43.30 and 39 ± 19.79 microns after the first, second and third PTK procedures, respectively. All eyes had a corneal haze. Prefirst PTK mean BCVA was 20/200 and improved significantly after the first two PTK procedures to 20/40 and after the third PTK procedure to 20/32 (P < 0.001). Five eyes had hyperopia. One acute graft rejection was managed successfully at 5 months with medical therapy.Conclusion:Multiple PTK procedures can be performed safely with improved visual acuity in grafts without compromising graft survival.

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Phototherapeutic keratectomy for BIGH3-linked corneal dystrophy recurring after penetrating keratoplasty

Cited by 32 publications

References 34 publications

Arg555Gln Mutation of TGFBI Gene in Geographical-Type Reis—Bücklers Corneal Dystrophy in a Chinese Family

Arg555Gln Mutation of TGFBI Gene in Geographical-Type Reis—Bücklers Corneal Dystrophy in a Chinese Family

Two Cases of Reis-Bücklers Corneal Dystrophy (Granular Corneal Dystrophy Type III) Caused by Spontaneous Mutations in the TGFBI Gene

Phototherapeutic keratectomy for recurrent granular dystrophy in postpenetrating keratoplasty eyes

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