Photosynthesis-dependent H2O2 transfer from chloroplasts to nuclei provides a high-light signalling mechanism

Expósito-Rodríguez, Marino; Laissue, Pierre Philippe; Yvon‐Durocher, Gabriel; Smirnoff, Nicholas; Mullineaux, Phil

doi:10.1038/s41467-017-00074-w

Cited by 296 publications

(305 citation statements)

References 68 publications

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“…Meanwhile, a recent study reported that plant basal thermotolerance varies diurnally, peaking during the day. This light‐dependent regulation of plant thermotolerance might be initiated by ROS signals, generated from the chloroplasts (Dickinson et al ), which could diffuse into the nucleus (Exposito‐Rodriguez et al ) to activate the transcription activity of the HSFA1s, regulating the expression of heat‐responsive genes such as HSP70 to increase the basal thermotolerance of plants (Dickinson et al ).…”

Section: High Ambient Temperature Signaling Mechanismsmentioning

confidence: 99%

Molecular mechanisms governing plant responses to high temperatures

Kang

Ren

et al. 2018

JIPB

206

181

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The increased prevalence of high temperatures (HTs) around the world is a major global concern, as they dramatically affect agronomic productivity. Upon HT exposure, plants sense the temperature change and initiate cellular and metabolic responses that enable them to adapt to their new environmental conditions. Decoding the mechanisms by which plants cope with HT will facilitate the development of molecular markers to enable the production of plants with improved thermotolerance. In recent decades, genetic, physiological, molecular, and biochemical studies have revealed a number of vital cellular components and processes involved in thermoresponsive growth and the acquisition of thermotolerance in plants. This review summarizes the major mechanisms involved in plant HT responses, with a special focus on recent discoveries related to plant thermosensing, heat stress signaling, and HT-regulated gene expression networks that promote plant adaptation to elevated environmental temperatures.

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Section: High Ambient Temperature Signaling Mechanismsmentioning

confidence: 99%

Molecular mechanisms governing plant responses to high temperatures

Kang

Ren

et al. 2018

JIPB

206

181

View full text Add to dashboard Cite

show abstract

“…Aquaporin-facilitated diffusion of uncharged H 2 O 2 across membranes (Bienert and Chaumont, 2014) may add to its role as a cellular signaling molecule. Recently, H 2 O 2 has been proposed as a mobile signal in the chloroplast retrograde response, where it originates from the organelle, moves to the nucleus, and might directly act on transcription factors (Exposito-Rodriguez et al, 2017). Exogenous application of H 2 O 2 in cell suspensions of Arabidopsis and Chlamydomonas has been shown to induce mitochondrial retrograde marker transcripts such as AOX1a and NDB2 (Vanlerberghe and McLntosh, 1996;Ho et al, 2008;Blaby et al, 2015).…”

Section: Which Molecules Qualify As Upstream Mitochondrial Signals? Rmentioning

confidence: 99%

Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants

et al. 2018

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ORCID IDs: 0000-0001-5369-7911 (S.W.); 0000-0003-4024-968X (O.V.A.); 0000-0003-0796-8308 (M.S.).Cells of complex organisms typically rely on mitochondria for energy provision. The amount of energy required to sustain cellular activity can vary strongly depending on external conditions. Vice versa, constraints on respiratory activity due to metabolic status or stress insult require mitochondrial signaling to coordinate cellular physiology with the function of the organelle. In this update, we review recent insights into plant mitochondrial energy signaling in the light of their significance to stress acclimation. First, we focus on the characteristic adjustments of the nuclear transcriptome that occur after pharmacological inhibition of the mitochondrial electron transport chain as the output of mitochondrial retrograde signaling. Second, we discuss the proteins that have recently been identified as regulators of the transcript responses and the emerging picture of their action as a signaling network. We then pose the question of how well our current models of inducing mitochondrial dysfunction relate to conditions that plants face naturally. We reason that low-oxygen stress shows striking similarities with electron transport inhibitors with respect to their impact on mitochondrial energy physiology upstream, as well as the cellular transcriptomic response. Finally, we highlight and discuss changes in mitochondrial physiology that are common to both stimuli as candidates for upstream signals. The aim of this update is to better define the physiological context in which mitochondrial signaling operates to provide new directions for future research. RESPONSES TO MITOCHONDRIAL ENERGY SIGNALING AT THE TRANSCRIPT LEVEL

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“…Illumination of these mutants for 15 min after a period of darkness has been shown to activate a distinct set of genes as a result of 1 O 2 production in chloroplasts, showing the relevance of lifetime and site production on ROS signaling (op den Camp et al, 2003). In contrast to 1 O 2 , H 2 O 2 can be produced in different compartments in plant cells and is a more stable ROS with higher diffusion distances of around 1 mm (Vestergaard et al, 2012), thus with the potential of being able to diffuse from chloroplasts to nuclei to modulate gene expression (Exposito-Rodriguez et al, 2017). The AsA-glutathione cycle plays a major role in H 2 O 2 detoxification in the water-water cycle.…”

Section: Photooxidative Stress In Leaves Flowers and Fruitsmentioning

confidence: 99%