Photoswitchable phthalocyanine-assembled nanoparticles for controlled “double-lock” photodynamic therapy

Cheng, Hongbo; Li, Xingshu; Kwon, Nahyun; Fang, Yanyan; Baek, Gain; Yoon, Juyoung

doi:10.1039/c9cc03960k

Cited by 18 publications

(8 citation statements)

References 35 publications

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“…In addition, PcN4‐BA displays excellent a‐PDT activity against both common and antibiotic‐resistant bacterial strains. Also, co‐assemblies of tetrasulfonate ZnPcs with positively charged diazobenzenes (NanoAzoPcs) show a‐PDT that can be controlled by varying the stoichiometric ratios of the components and using isomerization of azobenzene [71] …”

Section: Nanoassemblies With Antimicrobial Activitymentioning

confidence: 99%

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Self‐Assembled Porphyrinoids: One‐Component Nanostructured Photomedicines

2021

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Photodynamic therapy (PDT) is becoming a promising way to treat various kinds of cancers, with few side effects. Porphyrinoids are the most relevant photosensitizers (PS) in PDT, because they present high extinction coefficients, biocompatibility, and excellent photochemical behavior. To maximize therapeutic effects, polymer‐PS conjugates, and PS‐loaded nanoparticles have been developed, with insights in improving tumor delivery. However, some drawbacks such as non‐biodegradability, multistep fabrication, and low reagent loadings limit their clinical application. A novel strategy, noted by some authors as the “one‐for‐all” approach, is emerging to circumvent the use of additional delivery agents. This approach relies on the self‐assembly of amphiphilic PS to fabricate nanostructures with improved transport properties. In this review we focus on different rational designs of porphyrinoid PS to achieve some of the following attributes in nanoassembly: i) selective uptake, through the incorporation of recognizable biological vectors; ii) responsiveness to stimuli; iii) combination of imaging and therapeutic functions; and iv) multimodal therapy, including photothermal or chemotherapy abilities.

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Section: Nanoassemblies With Antimicrobial Activitymentioning

confidence: 99%

“…Also, co‐assemblies of tetrasulfonate ZnPcs with positively charged diazobenzenes (NanoAzoPcs) show a‐PDT that can be controlled by varying the stoichiometric ratios of the components and using isomerization of azobenzene. [71] …”

Section: Nanoassemblies With Antimicrobial Activitymentioning

confidence: 99%

Self‐Assembled Porphyrinoids: One‐Component Nanostructured Photomedicines

2021

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“…The phosphoryl-containing ZnPc, instead, remained in the cell periphery. Moreover, nanoparticles assembled by mixing a ZnPc derivative (4-sulfonatophenoxysubstituted ZnPc) and different azobenzene amphiphiles were reported as very appealing nanoplatform for antibacterial PDT [178].…”

Section: Pcs-based Supramolecular Assemblies For Photodynamic Therapymentioning

confidence: 99%

“…In particular, the compound Azo 1 (Figure 33) was found to induce the greatest change in the UV-Vis spectrum of ZnPc suggesting a strong host-guest interaction mediated by π-π stacking phenomena, as even confirmed by the recorded fluorescence quenching upon nanoparticles formation. Moreover, nanoparticles assembled by mixing a ZnPc derivative (4-sulfonatophenoxy-substituted ZnPc) and different azobenzene amphiphiles were reported as very appealing nanoplatform for antibacterial PDT [178].…”

Section: Pcs-based Supramolecular Assemblies For Photodynamic Therapymentioning

confidence: 99%

Applications of Photoinduced Phenomena in Supramolecularly Arranged Phthalocyanine Derivatives: A Perspective

2020

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This review focuses on the description of several examples of supramolecular assemblies of phthalocyanine derivatives differently functionalized and interfaced with diverse kinds of chemical species for photo-induced phenomena applications. In fact, the role of different substituents was investigated in order to tune peculiar aggregates formation as well as, with the same aim, the possibility to interface these derivatives with other molecular species, as electron donor and acceptor, carbon allotropes, cyclodextrins, protein cages, drugs. Phthalocyanine photo-physical features are indeed really interesting and appealing but need to be preserved and optimized. Here, we highlight that the supramolecular approach is a versatile method to build up very complex and functional architectures. Further, the possibility to minimize the organization energy and to facilitate the spontaneous assembly of the molecules, in numerous examples, has been demonstrated to be more useful and performing than the covalent approach.

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“…Over the past several decades, the rapid development of nanotechnology has shown great potential for the treatment of bacterial infections. [12][13][14] Given their small size, highly specic surface area, and unique chemical and physical properties, plenty of nanomaterials, such as metal nanoparticles (NPs), metal oxide NPs, carbon nanomaterials and their composites, have been explored as novel antibacterial agents. To date, many nanomaterials have been used in PDT, including TiO 2 nanostructures, ZnO nanocrystals and TAT-TMVCP nanostructure.…”

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confidence: 99%

Lactic-co-glycolic acid-coated methylene blue nanoparticles with enhanced antibacterial activity for efficient wound healing

Zhang

et al. 2020

RSC Adv.

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Photoswitchable phthalocyanine-assembled nanoparticles for controlled “double-lock” photodynamic therapy

Abstract: A new nanoparticle platform, NanoAzoPcS, is created by co-assembly of phthalocyanine and azobenzene amphiphiles, which can be used to gain precise control of PDT simply by regulating the stoichiometric ratio of the components and using light irradiation.

Cited by 18 publications

References 35 publications

Self‐Assembled Porphyrinoids: One‐Component Nanostructured Photomedicines

Self‐Assembled Porphyrinoids: One‐Component Nanostructured Photomedicines

Applications of Photoinduced Phenomena in Supramolecularly Arranged Phthalocyanine Derivatives: A Perspective

Lactic-co-glycolic acid-coated methylene blue nanoparticles with enhanced antibacterial activity for efficient wound healing

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