Photostable polymorphic organic cages for targeted live cell imaging

Kelabi, Dana Al; Dey, Avishek; Alimi, Lukman O.; Piwoński, Hubert; Habuchi, Satoshi; Khashab, Niveen M.

doi:10.1039/d2sc00836j

Cited by 8 publications

(14 citation statements)

References 50 publications

(70 reference statements)

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“…It has been crucial to design covalent cages with high biocompatibility and stability for biological applications. Khashab et al reported a water-soluble tautomeric covalent cage 33 composed of S,S-cyclohexanediamine and phloroglucinol with good cell permeability (Figure 10a), 104 which can be used for mitochondrial targeting through passive diffusion into cells (Figure 10b). In comparison with commercial mitochondrial indicators, covalent cage 33 has higher retention and stability in MCF-7 cells (Figure 10c).…”

Section: Biological Imagingmentioning

confidence: 99%

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Metallacages and Covalent Cages for Biological Imaging and Therapeutics

Dou

Yang

et al. 2023

ACS Materials Lett.

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Due to their precise three-dimensional structures and tunable cavities, metallacages and covalent cages have been widely used in various fields, such as catalysis, separation, sensing, and biomedicine. As a result of the unique pattern of directed synthesis and modular assembly, cages can be modified in many different ways to construct stimuli-responsive cages for marker detection and imaging in biological applications. Additionally, imaging agents and drugs can be loaded into the unique cavity of the cages to achieve precise disease diagnosis and treatment. This Review summarizes recent advances in metallacages and covalent cages in biological applications and presents their representative examples in imaging and therapeutics. The problems and future development directions of cages in biological applications are emphasized, which may provide clear guidance for the design and application of precise and controllable biological diagnostic reagents.

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Section: Biological Imagingmentioning

confidence: 99%

“…(c) Intracellular retention and photostability of cage 33 and RedFM in MCF-7 cells exposed to laser light. Reproduced from ref with permission. Copyright (2022), Royal Society of Chemistry.…”

Section: Metallacages and Covalent Cages For Biological Imagingmentioning

confidence: 99%

Metallacages and Covalent Cages for Biological Imaging and Therapeutics

Dou

Yang

et al. 2023

ACS Materials Lett.

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“…However, reports on the applications of PCCs in bioimaging remain rare, and the main focus is on enhancing fluorescence imaging by utilizing the fluorescence properties of ligand groups [ 66 ]. Porous organic cages (POCs), which are similar to PCCs but do not contain metals, are also a potential material for bioimaging [ 67 ].…”

Section: Porous Framework Materials In Bioimagingmentioning

confidence: 99%

“…Notably, the imine bonds in the coordination unit are completely transformed into amine bonds under mild conditions, which greatly improves its hydrophilicity and the efficiency of living cell imaging. Dana Al Kelabi et al [ 67 ] reported a reciprocal heterotrimeric organic cage with biological activity and mitochondrial targeting. They demonstrated that a biocompatible organic cage (OC1) can be employed as a mitochondria-targeted fluorescent probe with high cell permeability and impressive photostability.…”

Section: Porous Framework Materials In Bioimagingmentioning

confidence: 99%

Porous Framework Materials for Bioimaging and Cancer Therapy

et al. 2023

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Cancer remains one of the most pressing diseases in the world. Traditional treatments, including surgery, chemotherapy, and radiotherapy still show certain limitations. Recently, numerous cancer treatments have been proposed in combination with novel materials, such as photothermal therapy, chemodynamic therapy, immunotherapy, and a combination of therapeutic approaches. These new methods have shown significant advantages in reducing side effects and synergistically enhancing anti-cancer efficacy. In addition to the above approaches, early diagnosis and in situ monitoring of lesion areas are also important for reducing side effects and improving the success rate of cancer therapy. This depends on the decent use of bioimaging technology. In this review, we mainly summarize the recent advances in porous framework materials for bioimaging and cancer therapy. In addition, we present future challenges relating to bioimaging and cancer therapy based on porous framework materials.

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“…46 Another recent work revealed the ability of organic cage-type compounds, obtained through dynamic covalent synthesis, to readily cross cell membranes and enter cells. 47 In this work, we explored a dynamic covalent chemistry approach for the formation of porphyrin-peptide conjugates. We report the straightforward access to four cationic tetra-conjugates and eight cage-type structures displaying cell-penetrating and targeting groups.…”

Section: Introductionmentioning

confidence: 99%