Photostable near-infrared-absorbing diradical-platinum(<scp>ii</scp>) complex solubilized by albumin toward a cancer photothermal therapy agent

Sawamura, Ryota; Sato, Masataka; Masuya-Suzuki, Atsuko; Iki, Nobuhiko

doi:10.1039/d0ra00652a

Cited by 4 publications

(1 citation statement)

References 26 publications

(4 reference statements)

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“…In addition, it can be inferred that the introduction of isocyanide and alkynyl may improve the cytotoxic effect by comparing the cytotoxicity results of Pt(NˆN *C)Cl, (−)-2 and (−)-4. UV-vis spectroscopy has also checked the stability of the complexes obtained in DMSO and DMSO-PBS media [37]. The absorbance at 424 nm of the DMSO-PBS and DMSO solutions of (−)-2 decreases by ca.…”

Section: Cytotoxicitymentioning

confidence: 99%

Synthesis and Biological Activities of Luminescent 5,6-Membered Bis(Metallacyclic) Platinum(II) Complexes

Jing,

Yu,

Pan

et al. 2023

Molecules

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Four couples of 5,6-membered bis(metallacyclic) Pt(II) complexes with acetylide and isocyanide auxiliary ligands have been prepared and characterized. The structures of (−)-2 and (−)-3 are confirmed by single-crystal X-ray diffraction, showing a distorted square-planar coordination environment around the Pt(II) nucleus. Both solutions and solid samples of all complexes are emissive at RT. Acetylide-coordinated Pt(II) complexes have a lower energy emission than those isocyanide-coordinated ones. The emission spectra of N^N′*C-coordinated Pt(II) derivatives show a lower energy emission maximum relative to N^C*N′-coordinated complexes with the same auxiliary ligand. Moreover, the difference between cyclometalated N^N′*C and N^C*N′ ligands exerts a more remarkable effect on the emission than the auxiliary ligands acetylide and isocyanide. Cytotoxicity and cell imaging of luminescent 5,6-membered bis(metallacyclic) Pt(II) complexes have been evaluated.

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Section: Cytotoxicitymentioning

confidence: 99%

Synthesis and Biological Activities of Luminescent 5,6-Membered Bis(Metallacyclic) Platinum(II) Complexes

Jing,

Yu,

Pan

et al. 2023

Molecules

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Study on cellular uptake of a hydrophobic near-infrared-absorbing diradical-platinum(II) complex solubilized by albumin using hyperspectral imaging, spectrophotometry, and spectrofluorimetry

Sawamura,

Masuya-Suzuki,

Iki

2024

ANAL. SCI.

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Owing to its biopenetrability and minimal invasiveness, near-infrared (NIR) light in the region between 700–1100 nm has attracted attention in cancer diagnosis and therapy. Our group previously reported that the hydrophobic diradical-platinum(II) complex PtL2 is a promising agent for cancer photothermal therapy (L = 3,5-dibromo-1,2-diiminobenzosemiquinonate radical). Because PtL2 does not fluoresce, its intercellular uptake of PtL2 cannot be observed with a fluorescence microscope. In this study, we clarified the uptake and intracellular behavior of PtL2 solubilized by bovine serum albumin (BSA) using hyperspectral imaging enabling spectrophotometric analysis of the image. The spectral changes in the obtained images indicated that the internalization of PtL2 was followed by crystallization of the complex during the long incubation period (> 4 h). Additionally, the binding constant Kb = 5.91 × 104 M–1 could be estimated upon fluorescence quenching analysis of BSA upon binding of PtL2; Kb is two orders of magnitude smaller than that of albumin–common drugs. Considering the small Kb and low solubility of PtL2 in water, we ultimately proposed the internalization path and fate of PtL2 in the cell: release of PtL2 from BSA near cellular membranes and subsequent cellular uptake via membrane permeation followed by saturation, resulting in crystallization. Graphical abstract

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Development of a Diradical-platinum(II) Complex Equipped with a Linker Conjugatable to a Targeting-materials for Cancer-selective Imaging and Therapy

2022

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Photostable near-infrared-absorbing diradical-platinum(ii) complex solubilized by albumin toward a cancer photothermal therapy agent

Cited by 4 publications

References 26 publications

Synthesis and Biological Activities of Luminescent 5,6-Membered Bis(Metallacyclic) Platinum(II) Complexes

Synthesis and Biological Activities of Luminescent 5,6-Membered Bis(Metallacyclic) Platinum(II) Complexes

Study on cellular uptake of a hydrophobic near-infrared-absorbing diradical-platinum(II) complex solubilized by albumin using hyperspectral imaging, spectrophotometry, and spectrofluorimetry

Development of a Diradical-platinum(II) Complex Equipped with a Linker Conjugatable to a Targeting-materials for Cancer-selective Imaging and Therapy

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