Photostability study of commercial sunscreens submitted to artificial UV irradiation and/or fluorescent radiation

Romanhole, Rodrigo Colina; Ataide, Janaína Artem; Cefali, Letícia Caramori; Moriel, Patrícia; Mazzola, Priscila Gava

doi:10.1016/j.jphotobiol.2016.06.011

Cited by 18 publications

(10 citation statements)

References 31 publications

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“…Sun filters should not undergo modification when exposed to sunlight, therefore the photostability assay also becomes mandatory. According to Huong et al [20] and Romanhole et al [21], the instability of sun filters can decrease their absorptive capacity and consequently their capacity to protect the skin against harmful effects from solar radiation.…”

Section: Introductionmentioning

confidence: 99%

Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties

et al. 2019

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The aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend of extracts. The selected emulsion was stable when stored at low temperatures (5 °C), for which after 120 days the concentration of quercetin and rutin were above their limit of quantification, i.e., 2.8 ± 0.39 μg/mL and 30.39 ± 0.39 μg/mL, respectively. Spreadability, low rupture strength and adhesiveness were shown to be similar to a conventional topical product. Higher brittleness, pseudo-plastic, and viscoelastic behaviors were also recorded for the developed phytocosmetic sunscreen. The product presented a critical wavelength of 387.0 nm and ultraviolet rays A and B (UVA/UVB) rate of 0.78, confirming that the developed formulation shows capacity for UVA/UVB protection, protecting skin against damages caused by ultraviolet (UV) radiation. Rutin was shown to permeate the skin barrier and was also quantified in the stratum corneum (3.27 ± 1.92 μg/mL) by tape stripping and retention test (114.68 ± 8.70 μg/mL). The developed flavonoid-enriched phytocosmetic was shown to be non-irritant to skin by an in vitro assay. Our results confirm the antioxidant activity, sun protection, and physical properties of the developed phytocosmetic for topical application.

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Section: Introductionmentioning

confidence: 99%

Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties

et al. 2019

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“…All sunscreens undergo specific testing to determine the stability and photoprotective levels when exposed to sunlight, which determines their sun protection factor (SPF), but recent research suggests that sunscreens should be screened using artificial light as well, as one study found that several commercial sunscreen formulations had significantly decreased absorbance curves after fluorescent light exposure . Because of the broad exposure to nonsolar light in today's society, this may present a large challenge, as sunscreens may not be as effective as consumers believe, especially in the case of those used in cosmetics.…”

Section: Sunscreensmentioning

confidence: 99%

Melanoma Chemoprevention: Current Status and Future Prospects

Chhabra

Ndiaye

Garcia-Peterson

et al. 2017

Photochem & Photobiology

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The incidence of skin cancers, both non-melanoma as well as melanoma, are increasing in the United States. The ultraviolet radiation, mainly from sun, is considered the major cause for these neoplasms. While non-melanoma skin cancers are far more numerous, melanoma remains the most challenging. This is because melanoma can become extremely aggressive and its incidence is increasing worldwide due to lack of effective early detection, as well as disease recurrence, following both surgery and chemotherapy. Therefore, in addition to better treatment options, newer means are required to prevent melanomas from developing. Chemoprevention is a reasonable cost-effective approach to prevent carcinogenesis by inhibiting the processes of tumor initiation, promotion and progression. Melanoma is a progressive disease, which makes it very suitable for chemopreventive interventions, by targeting the processes and molecular pathways involved in the progression of melanoma. This review discusses the roles of various chemopreventive agents such as NSAIDs, statins, vitamins and dietary agents in melanoma and highlights current advancements and our perspective on future of melanoma chemoprevention. Although considerable preclinical data suggest that melanoma may be prevented or delayed by a numerous chemopreventive agents, we realize there are insufficient clinical studies evaluating their efficacy and long-term safety for human use.

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“…Sunscreens are topical products initially developed to prevent sunburns, but have further evolved to protect against other harmful effects of ultraviolet radiation, such as skin cancer, aging, wrinkle formation, undesired pigmentation, and collagen loss [9,10]. Ideal UV filters should be non-toxic, not cause allergic reactions, and not be systemically absorbed [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vitro Solar Protection Factor (SPF), Antioxidant Activity, and Cell Viability of Mixed Vegetable Extracts from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinífera L.

Cefali

Ataide

Fernandes

et al. 2019

Plants

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The aim of this study was to validate a HPLC method for the assay of flavonoids in extracts obtained from natural sources, i.e., from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinífera L. The potential sun protecting effect, antioxidant activity, and cell viability of the extracts were also determined. Individual extracts (obtained from each individual species) and a mixed extract (containing the four extracts) were analyzed by the validated HPLC method for the identification of flavonoids and quantification of rutin and quercetin. An in vitro cell viability study was carried out using the neutral red method. The in vitro sun protection factor was determined by spectral transmittance and in vitro antioxidant efficacy was evaluated against DPPH, ABTS, and AAPH radicals. The HPLC method used for the identification and quantification of flavonoids in extracts exhibited linearity, precision, accuracy, and robustness. Detection and quantification limits were, respectively, 2.881 ± 0.9 μg·mL−1 and 0.864 ± 0.9 μg·mL−1 for quercetin, and 30.09 ± 1 μg·mL−1 and 9.027 ± 1.1 μg·mL−1 for rutin. All extracts did not affect cell viability at the evaluated concentration range and exhibited a sun protection effect and antioxidant activity. Among the evaluated extracts, Ginkgo biloba L. and the mixed extract depicted the most expressive antioxidant activity. The mixed extract exhibited sunscreen protection against ultraviolet A (UVA) and ultraviolet B (UVB) and a critical wavelength of 372.7 ± 0.1. Our results translate the enhanced flavonoids’ composition of the mixed extract, which may be a potential alternative over sunscreens and antioxidants in pharmaceutic/cosmetic formulations.

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Photostability study of commercial sunscreens submitted to artificial UV irradiation and/or fluorescent radiation

Cited by 18 publications

References 31 publications

Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties

Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties

Melanoma Chemoprevention: Current Status and Future Prospects

Evaluation of In Vitro Solar Protection Factor (SPF), Antioxidant Activity, and Cell Viability of Mixed Vegetable Extracts from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinífera L.

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