Photosensitizing Furocoumarins: Content in Plant Matrices and Kinetics of Supercritical Carbon Dioxide Extraction

Woźniak, Łukasz; Połaska, Marzena; Marszałek, Krystian; Skąpska, Sylwia

doi:10.3390/molecules25173805

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…Psoralenes, in particular, are photosensitizing coumarin derivatives able to intercalate in the double helix of DNA accounting for some ancient attempts to treat skin diseases, such as vitiligo, eczema and psoriasis (ref. [123] and references therein).…”

Section: Coumarinsmentioning

confidence: 99%

Light and Autofluorescence, Multitasking Features in Living Organisms

Croce

2021

Photochem

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Organisms belonging to all life kingdoms may have the natural capacity to fluoresce. Autofluorescence events depend on the presence of natural biomolecules, namely endogenous fluorophores, with suitable chemical properties in terms of conjugated double bonds, aromatic or more complex structures with oxidized and crosslinked bonds, ensuring an energy status able to permit electronic transitions matching with the energy of light in the UV-visible-near-IR spectral range. Emission of light from biological substrates has been reported since a long time, inspiring unceasing and countless studies. Early notes on autofluorescence of vegetables have been soon followed by attention to animals. Investigations on full living organisms from the wild environment have been driven prevalently by ecological and taxonomical purposes, while studies on cells, tissues and organs have been mainly promoted by diagnostic aims. Interest in autofluorescence is also growing as a sensing biomarker in food production and in more various industrial processes. The associated technological advances have supported investigations ranging from the pure photochemical characterization of specific endogenous fluorophores to their possible functional meanings and biological relevance, making fluorescence a valuable intrinsic biomarker for industrial and diagnostic applications, in a sort of real time, in situ biochemical analysis. This review aims to provide a wide-ranging report on the most investigated natural fluorescing biomolecules, from microorganisms to plants and animals of different taxonomic degrees, with their biological, environmental or biomedical issues relevant for the human health. Hence, some notes in the different sections dealing with different biological subject are also interlaced with human related issues. Light based events in biological subjects have inspired an almost countless literature, making it almost impossible to recall here all associated published works, forcing to apologize for the overlooked reports. This Review is thus proposed as an inspiring source for Readers, addressing them to additional literature for an expanded information on specific topics of more interest.

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Section: Coumarinsmentioning

confidence: 99%

Light and Autofluorescence, Multitasking Features in Living Organisms

Croce

2021

Photochem

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“…that may follow this novel Type III photochemistry. Psoralens, for example, belong to the group of compounds called furanocoumarins that are frequently found in plants [ 57 ]. Psoralen was previously applied with Ultraviolet A (UVA) to treat various skin diseases.…”

Section: Light-based Anti-infective Agents: Can They Overcome Antimic...mentioning

confidence: 99%

Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

Leanse,

Marasini,

dos Anjos

et al. 2023

Antibiotics

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In recent years, with the increases in microorganisms that express a multitude of antimicrobial resistance (AMR) mechanisms, the threat of antimicrobial resistance in the global population has reached critical levels. The introduction of the COVID-19 pandemic has further contributed to the influx of infections caused by multidrug-resistant organisms (MDROs), which has placed significant pressure on healthcare systems. For over a century, the potential for light-based approaches targeted at combatting both cancer and infectious diseases has been proposed. They offer effective killing of microbial pathogens, regardless of AMR status, and have not typically been associated with high propensities of resistance development. To that end, the goal of this review is to describe the different mechanisms that drive AMR, including intrinsic, phenotypic, and acquired resistance mechanisms. Additionally, the different light-based approaches, including antimicrobial photodynamic therapy (aPDT), antimicrobial blue light (aBL), and ultraviolet (UV) light, will be discussed as potential alternatives or adjunct therapies with conventional antimicrobials. Lastly, we will evaluate the feasibility and requirements associated with integration of light-based approaches into the clinical pipeline.

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“…Both natural and synthetic coumarin derivatives present a wide range of biological properties [ 10 , 11 , 12 , 13 , 14 , 15 ], such as anticancer [ 16 , 17 ], anti-HIV [ 18 , 19 ], anti-SARS-CoV-2 [ 3 ], antidiabetic [ 20 , 21 ], anti-inflammatory [ 22 , 23 ], anticoagulant [ 24 , 25 ], antibiotic [ 26 , 27 ], antitubercular [ 28 , 29 ], neuroprotective [ 30 , 31 ], anti-infectious hematopoietic necrosis virus activities (IHNV) [ 32 ], etc. Fused coumarins possess also biological activities, and many of them, like furocoumarins [ 33 , 34 ], pyranocoumarins [ 35 ] or pyridocoumarins [ 36 ] are isolated from nature. Fused pyrrolocoumarins display interesting biological properties, such as cytotoxic [ 37 , 38 , 39 , 40 , 41 , 42 ], antibacterial [ 42 ], anti-HIV [ 37 , 42 , 43 , 44 , 45 ], multidrug resistance reversal (MDR) [ 37 , 42 , 45 ], antibiotic [ 42 ], antioxidant [ 42 , 46 , 47 ], antitumor […”

Section: Introductionmentioning

confidence: 99%

An Overview of the Synthesis of 3,4-Fused Pyrrolocoumarins of Biological Interest

Kapidou,

Litinas

2024

Molecules

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3,4-Fused pyrrolocoumarins, synthetically prepared or naturally occurring, possess interesting biological properties. In this review, the synthetic strategies for the synthesis of the title compounds are presented along with their biological activities. Two routes are followed for that synthesis. In one, the pyrrole ring is formed from coumarin derivatives, such as aminocoumarins or other coumarins. In the other approach, the pyranone moiety is built from an existing pyrrole derivative or through the simultaneous formation of coumarin and pyrrole frameworks. The above syntheses are achieved via 1,3-dipolar cycloaddition reactions, Michael reaction, aza-Claisen rearrangement reactions, multi-component reactions (MCR), as well as metal-catalyzed reactions. Pyrrolocoumarins present cytotoxic, antifungal, antibacterial, α-glucosidase inhibition, antioxidant, lipoxygenase (LOX) inhibition, and fluorescent activities, as well as benzodiazepine receptor ability.

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Photosensitizing Furocoumarins: Content in Plant Matrices and Kinetics of Supercritical Carbon Dioxide Extraction

Cited by 7 publications

References 36 publications

Light and Autofluorescence, Multitasking Features in Living Organisms

Light and Autofluorescence, Multitasking Features in Living Organisms

Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

An Overview of the Synthesis of 3,4-Fused Pyrrolocoumarins of Biological Interest

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