Photosensitizer-loaded electrospun chitosan-based scaffolds for photodynamic therapy and tissue engineering

Severyukhina, A N; Petrova, N. V.; Smuda, Kathrin; Terentyuk, Georgy S.; Klebtsov, B.N.; Georgieva, Radostina; Bäumler, Hans; Gorin, Dmitry A.

doi:10.1016/j.colsurfb.2016.03.081

Cited by 40 publications

(26 citation statements)

References 52 publications

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“…Another commonly used treatment option for skin cancers is the photodynamic therapy (PDT). PDT consists on the application of photosensitizing agents that in the presence of oxygen and irradiation at specific wavelength, can potentially kill cancer cells based on the formation of reactive oxygen species (ROS) (Severyukhina et al, 2016). For this purpose, zinc phthalocyanine tetrasulfonic acid (ZnPcS 4 ) was incorporated into an HEC gel and this drug penetration was evaluated in vitro using porcine ear skin and in vivo both in healthy hairless mice and in human SCC (A431 cells) tumors induced in immunosuppressed mice (Souza et al, 2011;Lemos et al, 2016).…”

Section: Physical Methods For a Topical Tre-atment Iontophoresismentioning

confidence: 99%

Physical methods for topical skin drug delivery: concepts and applications

Petrilli

Lopez

2018

Braz. J. Pharm. Sci.

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Topical drug delivery is an interesting approach to treat skin diseases and to avoid pain and low patient compliance in cases where a systemic delivery is required. However, the stratum corneum, which is the outermost skin layer, strongly protects the body from the entrance of substances, especially those hydrophilic. In this context, different physical methods have been studied to overcome the stratum corneum barrier and facilitate penetration of drugs into or through the skin. Among them, iontophoresis, low-frequency ultrasound and microneedles have been widely employed for transdermal drug delivery. More recently, they are also studied to aid in the treatment of dermatological disorders, such as skin tumors and inflammation. Basically, iontophoresis refers to the movement of charged and non-charged hydrophilic molecules through the skin due to the application of a low constant electric current and the contributions of electromigration and electroosmosis. In low-frequency ultrasound, cavitation is the main mechanism for skin permeabilization that consists on the formation of microbubbles that disorganize the stratum corneum. Microneedles are microprojections, minimally invasive, that can be designed with different lengths, materials and geometry to increase skin permeability. In this review, concepts, mechanisms and applications of these three physical methods will be presented and discussed with focus on their use in dermatological treatments. Moreover, comparative studies using different physical methods will be presented and also some clinical perspectives will be addressed.

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Section: Physical Methods For a Topical Tre-atment Iontophoresismentioning

confidence: 99%

Physical methods for topical skin drug delivery: concepts and applications

Petrilli

Lopez

2018

Braz. J. Pharm. Sci.

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“…Conventional PDT induces relatively large amount of photosensitizer by intravenous, which may result in skin photosensitivity and high uptaking by normal cells . The use of nanofibrous scaffold for delivering photosensitizers reduces the therapeutic dosage significantly.…”

Section: Electrospun Nanofibers For Photodynamic Therapymentioning

confidence: 99%

“…Electrospun nanofibers for cancer PDT can achieve considerable selective therapeutic effect by simply focusing the light on the scaffold‐localized tumor region. [128a,136] Severyukhina et al reported a type of photosensitizer‐loaded electrospun fibers for photodynamic cancer therapy . Chitosan/PEO nanofibers consisting of different Photosens were synthesized by electrospinning.…”

Section: Electrospun Nanofibers For Photodynamic Therapymentioning

confidence: 99%

“…Conventional PDT induces relatively large amount of photosensitizer by intravenous, which may result in skin photosensitivity and high uptaking by normal cells. [23, 131] The use of nanofibrous scaffold for deliverying photosensitizers reduces the therapeutic dosage significantly. Studies of photosensitizer loaded nanofibers in the application of antibacterial, [132] catalysis, [133] water treatment [134] and wound healing [135] have been reported extensively.…”

Section: Electrospun Nanofibers For Photodynamic Therapymentioning

confidence: 99%

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Multifunctional Electrospun Nanofibers for Enhancing Localized Cancer Treatment

Ren

et al. 2018

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Localized cancer treatment is one of the most effective strategies in clinical destruction of solid tumors at early stages as it can minimize the side effects of cancer therapeutics. Electrospun nanofibers have been demonstrated as a promising implantable platform in localized cancer treatment, enabling the on-site delivery of therapeutic components and minimizing side effects to normal tissues. This Review discusses the recent cutting-edge research with regard to electrospun nanofibers used for various therapeutic approaches, including gene therapy, chemotherapy, photodynamic therapy, thermal therapy, and combination therapy, in enhancing localized cancer treatment. Furthermore, it extensively analyzes the current challenges and potential breakthroughs in utilizing this novel platform for clinical transition in localized cancer treatment.

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“…For example, the target specificity PDT of chlorin e 6 was strongly improved by its conjugation to a 19 nucleotide RNA aptamer AIR‐3A that binds efficiently the interleukin‐6 receptor , allowing the internalization into the cell via receptor‐mediated endocytosis. Failure to localize in organelles has been recognized due to sensitizers that are highly water soluble . Quantum dots (QDs) have been recently conjugated to sensitizers due to their increased photostability and because their optical properties can be shifted from the UV to the infrared region by tuning size, shape and composition, and their efficiency in acting as donor species in FRET processes .…”

Section: Sensitizer Types Multiphoton and Plasmonics Topicsmentioning

confidence: 99%

Targeting Photochemical Scalpels or Lancets in the Photodynamic Therapy Field—The Photochemist's Role

Protti

Albini

Viswanathan

et al. 2017

Photochem & Photobiology

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This review covers photochemical approaches aimed at supplementing surgical instruments with handheld photodynamic therapy (PDT) instruments. PDT is not widely used in hospitals, because of the laser equipment and expertise needed, and because insurance policies often do not cover the procedure. Accordingly, this review focuses on advances in photochemistry, photophysics, nanotechnology and miniaturization techniques that may likely inspire the use of handheld instruments in PDT. A takeaway point is that the advent of photochemical scalpels or lancets that deliver reactive oxygen species (ROS) on site may better equip medical practitioners and allow for eradication of tumors or infections in general. Specifically, the review is divided into several sections: sensitizer types, multiphoton and plasmonic topics, sensitizer delivery, light delivery, dosimetry, fiber optics and handheld implements in PDT.

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Photosensitizer-loaded electrospun chitosan-based scaffolds for photodynamic therapy and tissue engineering

Cited by 40 publications

References 52 publications

Physical methods for topical skin drug delivery: concepts and applications

Physical methods for topical skin drug delivery: concepts and applications

Multifunctional Electrospun Nanofibers for Enhancing Localized Cancer Treatment

Targeting Photochemical Scalpels or Lancets in the Photodynamic Therapy Field—The Photochemist's Role

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