Photosensitizer-Laden Neutrophils Are Controlled Remotely for Cancer Immunotherapy

Li, Yan; Han, Yi; Su, Runping; Liu, Y.; Chong, Gaowei; Xu, Dailin; He, Ruiqing; Liu, Ying; Dong, Haiqing; Shi, Donglu; Li, Yongyong

doi:10.1016/j.celrep.2020.108499

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…However, with the progression of tumor, the established tumor microenvironment instead is converted to immune-suppressive microenvironment, which attenuates such biochemotactic effect 34 , 35 . To reinforce this, various attempts have made to enhance the inflammation in tumor tissue by external photodynamic and photothermal therapies 36 , 37 , 38 , 39 , while the limited tissue penetration of the light strongly restricts their clinical applications. Notably, the neutrophils have also been exploited as vehicles to deliver anti-cancer drugs into glioma attributable to intrinsic activity of neutrophils to cross BBB/BTB and penetrate into glioma tissue 40 .…”

Section: Introductionmentioning

confidence: 99%

Salmonella-mediated blood‒brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

Yao

Yan

et al. 2023

Acta Pharmaceutica Sinica B

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Section: Introductionmentioning

confidence: 99%

Salmonella-mediated blood‒brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

Yao

Yan

et al. 2023

Acta Pharmaceutica Sinica B

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“…Although a controversial issue, some studies have reported a predisposition of neutrophils to target cancer cells, which is often leveraged to develop novel cell-based drug delivery systems 57 , 58 . In this regard, one of the main advantages of neutrophils is that they are present in high amounts in blood under normal circumstances, and they could theoretically outnumber and adversely affect tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release

García-Navas

Gajate

Mollinedo

2021

Sci Rep

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Human neutrophils constitutively express high amounts of arginase-1, which depletes arginine from the surrounding medium and downregulates T-cell activation. Here, we have found that neutrophil arginase-1, released from activated human neutrophils or dead cells, induced apoptosis in cancer cells through an endoplasmic reticulum (ER) stress pathway. Silencing of PERK in cancer cells prevented the induction of ER stress and apoptosis. Arginase inhibitor Nω-hydroxy-nor-arginine inhibited apoptosis and ER stress response induced by conditioned medium from activated neutrophils. A number of tumor cell lines, derived from different tissues, were sensitive to neutrophil arginase-1, with pancreatic, breast, ovarian and lung cancer cells showing the highest sensitivity. Neutrophil-released arginase-1 and arginine deprivation potentiated the antitumor action against pancreatic cancer cells of the ER-targeted antitumor alkylphospholipid analog edelfosine. Our study demonstrates the involvement of neutrophil arginase-1 in cancer cell killing and highlights the importance and complex role of neutrophils in tumor surveillance and biology.

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“…Upon illumination, the embedded Ce6 is activated to induce ROS generation and NET formation, leading to intensified cytolytic effect and significant tumor growth inhibition. [ 90 ]…”

Section: Neutrophil‐based Drug Delivery Systemsmentioning

confidence: 99%

Engineering and Targeting Neutrophils for Cancer Therapy

Zhang,

Gu,

Wang

et al. 2024

Advanced Materials

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Neutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that neutrophils possess heterogeneous phenotypes and functional plasticity in human health and diseases, including cancer. Neutrophils play multifaceted roles in cancer development and progression, and an N1/N2 paradigm of neutrophils in cancer has been proposed, where N1 neutrophils exert anti‐tumor properties while N2 neutrophils display tumor‐supportive and immune‐suppressive functions. Selective activation of beneficial neutrophil population and targeted inhibition or re‐polarization of tumor‐promoting neutrophils has shown an important potential in tumor therapy. In addition, due to the natural inflammation‐responsive and physical barrier‐crossing abilities, neutrophils and their derivatives (membranes and extracellular vesicles) are regarded as advanced drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. In this review, we comprehensively presented the recent advances in engineering neutrophils for drug delivery and targeting neutrophils for remodeling tumor microenvironment. This review will provide a broad understanding of the potential of neutrophils in cancer therapy.This article is protected by copyright. All rights reserved

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Photosensitizer-Laden Neutrophils Are Controlled Remotely for Cancer Immunotherapy

Cited by 7 publications

References 37 publications

Salmonella-mediated blood‒brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

Salmonella-mediated blood‒brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release

Engineering and Targeting Neutrophils for Cancer Therapy

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