Photosensitizer encapsulated organically modified silica nanoparticles for direct two-photon photodynamic therapy and In Vivo functional imaging

Qian, Jun; Wang, Dan; Cai, Fuhong; Zhan, Qiuqiang; Wang, Yalun; He, Sailing

doi:10.1016/j.biomaterials.2012.02.053

Cited by 139 publications

(104 citation statements)

References 32 publications

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“…They also initiate an inflammatory microenvironment that leads to cancer cell death. 181 The first approved photosensitizer, Photofrin, is a composite of oligomeric porphyrins that has been applied for the treatment of lung cancer, esophagus cancer, and other types of cancer. In 1993, Photofrin was applied for the first time in PDT to treat bladder tumors.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

211

149

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Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

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Section: Photodynamic Therapymentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

211

149

View full text Add to dashboard Cite

show abstract

“…IR820 can be easily metabolized by the liver. 24,25 Due to its good biosecurity, IR820 was employed as the photothermal agent in this study. 26,27 To further improve the theranostic efficiency and provide a way to image the pathological characteristics of tumors, it is necessary to develop a more effective theranostic agent to sense subtle pathological changes.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

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The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed “bomb-like” light-triggered CAs (LTCAs) for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR) light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T 1 relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy.

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“…Different containers have been suggested as carriers of drugs and photosensitizers, including calcium phosphate [13] and silica nanoparticles [14]. To solve the drug localization problem, the use of calcium carbonate microparticles (CaCO 3 ) in the vaterite polymorphic form was earlier suggested in [15].…”

Section: Introductionmentioning

confidence: 99%

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Genina

Svenskaya

Yanina

et al. 2016

Biomed. Opt. Express

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Abstract:We have developed a method for delivery of biocompatible CaCO 3 microcontainers (4.0 ± 0.8 µm) containing Fe 3 O 4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 μm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

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Photosensitizer encapsulated organically modified silica nanoparticles for direct two-photon photodynamic therapy and In Vivo functional imaging

Cited by 139 publications

References 32 publications

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

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