Photosensitizer-conjugated magnetic nanoparticles for in vivo simultaneous magnetofluorescent imaging and targeting therapy

Huang, Peng; Li, Zhiming; Lin, Jing; Yang, Da‐Peng; Gao, Guo; Xu, Cheng; Bao, Le; Zhang, Chunlei; Wang, Kan; Shi, Hua; Hu, Hengyao; Cui, Daxiang

doi:10.1016/j.biomaterials.2011.01.032

Cited by 252 publications

(175 citation statements)

References 64 publications

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“…178 Also, some hybrid materials that combine photosensitizers and NPs have been described. [179][180][181][182] In all the above examples, PDT is achieved by direct light excitation of photosensitizers, which may be or may not be tagged on passive NPs, cf. Fig.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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Abstract. Continuous advances in the field of bionanotechnology, particularly in the areas of synthesis and functionalization of colloidal inorganic nanoparticles with novel physicochemical properties, allow the development of innovative and/or enhanced approaches for medical solutions. Many of the present and future applications of bionanotechnology rely on the ability of nanoparticles to efficiently interact with electromagnetic (EM) fields and subsequently to produce a response via scattering or absorption of the interacting field. The crosssections of nanoparticles are typically orders of magnitude larger than organic molecules, which provide the means for manipulating EM fields and, thereby, enable applications in therapy (e.g., photothermal therapy, hyperthermia, drug release, etc.), sensing (e.g., surface plasmon resonance, surface-enhanced Raman, energy transfer, etc.), and imaging (e.g., magnetic resonance, optoacoustic, photothermal, etc.). Herein, an overview of the most relevant parameters and promising applications of EM-active nanoparticles for applications in life science are discussed with a view toward tailoring the interaction of nanoparticles with EM fields. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Photodynamic Therapymentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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“…H. pylori can also induce gastric atrophic lesion in Mongolian gerbils in 6 months and gastric cancer in 18 months [43]. Sipponen P. et al thought that atrophic gastritis is a direct result of the H.pylori infection, H.pylori gastritis triggers a variety of reactions, with the reaction cascades resulting in errors of the cell genome and ending up as neoplastic tumors [17,42]. In fact, chronic atrophic gastritis of high incidence in Helicobacter pylori infection has not been clearly pathogenically explained yet [43][44][45], its concrete mechanism is still unclarified.…”

Section: Discussionmentioning

confidence: 99%

“…This technique has great potential as a practical clinical tool for medical diagnosis. As part of the preliminary effort to establish a prewarning data library of early gastric cancer based on biological microarrays and CAD technology [11,12], we have been screening and cloning differentially expressed genes between precancerous lesion and gastric cancer, and also designed and prepared nanoprobes to find early in situ gastric cancer, with the aim of establishing a gastric cancer prewarning system [13][14][15][16][17][18][19][20][21][22]. The present study is a coherent part of our overall activities on molecular mechanism of gastric diseases including gastritis, precancerous lesion and carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Profiles of Rodent Atrophic Gastritis Induced By Hot and Salt Water

Xu¹,

Zhang²,

Zhang³

et al. 2011

Nano BioMed ENG

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Diet factors may be potential causes for atrophic gastritis. This study is to establish rat atrophic gastritis models under various hot and salt water conditions and to explore the associated molecular mechanisms. 96 SD rats were divided randomly into 4 experimental groups and used to establish atrophic gastritis models. 2 rats from each group were sacrificed every other week to collect gastric sinus tissues for pathological analysis. When atrophic lesion was identified in a given group, all remaining rats in that group were sacrificed and gastric sinus tissues were collected. The cDNA probes from sinus atrophic lesion or control sinus mucous were labeled with Cy5 or Cy3, respectively. These probes were mixed and hybridized with cDNA microarrays. Hot salt water group was pathologically confirmed to exhibit atrophic lesion in 10 weeks. Salt water group and hot water group were confirmed to exhibit atrophic lesion in 24 weeks. The atrophic lesions located mainly in gastric sinus. 288 differentially expressed genes were identified between hot salt water group and normal control group. 162 differentially expressed genes were identified between hot water group and normal control group. 81 differentially expressed genes were identified between hot salt water group and salt water group. In conclusion, rat atrophic gastritis models induced by various hot and salt water conditions have been established. The corresponding gene expression profiles have been firstly established. This study shows that dietary factors such as temperature and salt concentration may play an important role in the development of atrophic gastritis.

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“…However, the drawbacks of photosensitizers include poor water solubility and inadequate selectivity, which limit clinical applications. To address this challenge, Huang et al 28 rendered one of the second-generation photosensitizers, chlorine e6, covalently anchored on the surface of magnetic NPs with a silane coupling agent, resulting in a theranostic nanoparticle (∼20 nm in diameter) giving advantageous water solubility and biocompatibility, as well as noncytotoxicity and remarkable photodynamic efficacy. Such synthesized multifunctional nanocarriers were effective in simultaneous targeting by PDT in dual modality of NIR fluorescence and MRI of gastric cancer tissue in vivo.…”

Section: Magnetic Nanomaterialsmentioning

confidence: 99%

Nanotheranostics – a review of recent publications

Wang¹,

Chuang²,

Ho³

2012

IJN

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Theranostics is referred to as a treatment strategy that combines therapeutics with diagnostics, aiming to monitor the response to treatment and increase drug efficacy and safety, which would be a key part of personalized medicine and require considerable advances in predictive medicine. Theranostics associates with both a diagnosis that tests patients for possible reactions to taking new medication and targeted drug delivery based on the test results. Emerging nanotechnology provides a great deal of opportunity to design and develop such combination agents, permitting the delivery of therapeutics and concurrently allowing the detection modality to be used not only before or after but also throughout the entire treatment regimen. The introduction of nanotheranostics into routine health care has still a long way to go, since evaluations on cytotoxicity, genotoxicity, and immunotoxicity of prospective nanotheranostics, demonstration of cost-effectiveness, and availability of appropriate accessible testing systems are still required. An extensive review, from a chemistry point of view, of the recent development of nanotheranostics and its in vitro and in vivo applications are herein presented.

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Photosensitizer-conjugated magnetic nanoparticles for in vivo simultaneous magnetofluorescent imaging and targeting therapy

Cited by 252 publications

References 64 publications

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Gene Expression Profiles of Rodent Atrophic Gastritis Induced By Hot and Salt Water

Nanotheranostics – a review of recent publications

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Photosensitizer-conjugated magnetic nanoparticles for in vivo simultaneous magnetofluorescent imaging and targeting therapy

Cited by 252 publications

References 64 publications

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Gene Expression Profiles of Rodent Atrophic Gastritis Induced By Hot and Salt Water

Nanotheranostics &ndash; a review of recent publications

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Nanotheranostics – a review of recent publications