Photosensitization with anthraquinone derivatives: optical and EPR spin trapping studies of photogeneration of reactive oxygen species

Mothilal, K.K.; Inbaraj, Johnson J.; Gandhidasan, R.; Murugesan, R.

doi:10.1016/s1010-6030(03)00290-9

Cited by 29 publications

(23 citation statements)

References 33 publications

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“…We followed well established EPR spin-trapping techniques using 2,2,6,6-tetramethyl-4-piperidinol (TEMPL, Sigma Aldrich, USA) to test for 1 O 2 production, and 5,5-dimethyl-1-pyrroline N-oxide (DMPO, Caymen Chemical, Florida, USA) to test for OH (Mothilal et al, 2004;Zhao et al, 2008). To test the singlet oxygen assay, rose bengal (Fisher Scientific, USA) was used at 10 mM in deionized control experiments as a positive confirmation of 1 O 2 detection (Mothilal et al, 2004). Beta-carotene (Fisher Scientific, USA) is a quencher specific to singlet oxygen and was used to provide evidence that an observed signal is in fact from singlet oxygen (Sachindra et al, 2007).…”

Section: Photoactivity Experimentsmentioning

confidence: 99%

Stability, metal leaching, photoactivity and toxicity in freshwater systems of commercial single wall carbon nanotubes

Bennett

Adeleye

et al. 2013

Water Research

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Section: Photoactivity Experimentsmentioning

confidence: 99%

Stability, metal leaching, photoactivity and toxicity in freshwater systems of commercial single wall carbon nanotubes

Bennett

Adeleye

et al. 2013

Water Research

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“…To test whether the ROS detected from the RNO bleaching assay was 1 O 2 , we added sodium azide (NaN 3 ), a physical quencher of 1 O 2 [ 36 ], to TPEPy-I nanoaggregates under the same conditions. As displayed in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…5 b reveal that 1 O 2 produced by TPEPy-I varies with MW power. To validate that decrease in ABDA absorbance was due to the generation of 1 O 2 , we mixed DABCO, a well-known scavenger of 1 O 2 [ 36 ], to the solution of TPEPy-I (15 μM). As displayed in Fig.…”

Section: Resultsmentioning

confidence: 99%

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

Pandey

Wang

et al. 2022

Bioactive Materials

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Aggregation-induced emission luminogens (AIEgens) exhibit efficient cytotoxic reactive oxygen species (ROS) generation capability and unique light-up features in the aggregated state, which have been well explored in image-guided photodynamic therapy (PDT). However, the limited penetration depth of light in tissue severely hinders AIEgens as a candidate for primary or adjunctive therapy for clinical applications. Coincidentally, microwaves (MWs) show a distinct advantage for deeper penetration depth in tissues than light. Herein, for the first time, we report AIEgen-mediated microwave dynamic therapy (MWDT) for cancer treatment. We found that two AIEgens ( TPEPy-I and TPEPy-PF6 ) served as a new type of microwave (MW) sensitizers to produce ROS, including singlet oxygen ( 1 O 2 ), resulting in efficient destructions of cancer cells. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and live/dead assays reveal that the two AIEgens when activated by MW irradiation can effectively kill cancer cells with average IC-50 values of 2.73 and 3.22 μM, respectively. Overall, the ability of the two AIEgens to be activated by MW not only overcomes the limitations of conventional PDT, but also helps to improve existing MW ablation therapy by reducing the MW dose required to achieve the same therapeutic outcome, thus reducing the occurrence of side-effects of MW radiation.

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“…Anthraquinone (AQ) is an effective photosensitizer [41][42][43][44][45] as well as a common redox-active material for electroanalytical chemistry. [46][47][48][49][50] Okamoto et al reported for the first time on the photostimulated hole transport through DNA duplexes immobilized on gold electrodes.…”

Section: Small Organic Moleculesmentioning

confidence: 99%

Photoelectrochemically active species and photoelectrochemical biosensors

et al. 2013

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Photoelectrochemical biosensors developed from solar cells have received increasing attention due to their desirable sensitivity and better analytical performance. In recent decades, much attention has been paid to the preparation of photoelectrochemical biosensors. This paper aims to provide an overview on the development of photosensitizers, including the sensing principle of photoelectrochemical biosensors and a special kind of photoelectrochemical biosensor without external irradiation. The latest developments and applications are also included.

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Photosensitization with anthraquinone derivatives: optical and EPR spin trapping studies of photogeneration of reactive oxygen species

Cited by 29 publications

References 33 publications

Stability, metal leaching, photoactivity and toxicity in freshwater systems of commercial single wall carbon nanotubes

Stability, metal leaching, photoactivity and toxicity in freshwater systems of commercial single wall carbon nanotubes

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

Photoelectrochemically active species and photoelectrochemical biosensors

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