Photosensitization and controlled photosensitization with BODIPY dyes

Abstract

Highly versatile BODIPY dyes proved themselves to be very useful as photosensitizers. These dyes can be derivatized to absorb essentially anywhere in the visible the near IR region of the spectrum. As a result of their diverse reactivity, singlet oxygen generation efficiency can be modulated very precisely, leading to a number of selective photosensitizers for photodynamic therapy. Among the biologically relevant modulators, glutathione concentration and pH received particular attention. In this review, we highlight modulatable BODIPY-based photodynamic photosensitizers, and various synthetically useful chemical reactions triggered by singlet oxygen and other reactive oxygen species generated by BODIPY-based photosensitizers.

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

“…A number of dye sensitizers, including porphyrin, phthalocyanine, and cyanine, have been assessed for cancer treatment using PDT and/or PTT . Boron dipyrromethene (BODIPY) has attracted much interest with respect to cancer phototherapy because it possesses unique chemical and physical properties: intense absorption at relatively long wavelength, long triplet excited state lifetime, and excellent photostability . In addition, BODIPY synthesis and modification are facile and readily controllable .…”

Synthesis and Tunable Optical Properties of C,N‐Chelated Borate Luminophores Derived from Potassium Acyltrifluoroborates

“…Luminescent tetra‐coordinated borates are of significant importance in organic chemistry and materials science owing to their excellent optical properties and high photochemical stability . Such compounds have already been applied in the context of fluorescence imaging, photodynamic therapy, and electroluminescence devices . Intense efforts have also been devoted to developing a diverse range of novel borate luminophores, which includes, for example, boron‐dipyrromethene (BODIPY) dyes, boron β‐diketonate complexes, and boranils …”

Iodo‐Functionalized Salicylideneimine‐Boron Complexes: Synthesis and Photosensitized Degradation of Organic Water Pollutants

“…Introduction of heavy atoms or transition metal ions is a commonly followed approach to improve the photosensitization efficiency of organic photosensitizers . Porphyrins and phthalocyanines are the most studied class of organic photosensitizers whereas molecules like BODIPYs have emerged as a new class of molecules with good photosensitization properties …”

“…[7][8][9][10][11] Porphyrins and phthalocyanines are the most studied class of organic photosensitizers whereas molecules like BODIPYsh ave emerged as an ew class of molecules with good photosensitization properties. [12][13][14][15][16] Boron-containing compounds,s uch as boranils wherein the boron is coordinated to an organic ligand,h ave remarkable photophysical properties. [17][18][19][20] The overlap of the empty p-orbital of boron with the organic moieties in such compounds leads to the delocalizationo ft he electron cloud and planarization of the p-systems, therebyr esultingi ni nteresting photophysicalp roperties.…”